6 replies to this topic

[manofsan]

Here's one you sun-worshipppers might like:

http://news.bbc.co.u...lth/4199992.stm

I wonder if this has greater applications than just skin cream? Could it be ingested in pill form as well?

[John Schloendorn]

when used daily for a year on people who were susceptible to the disease

Be careful with "greater applications". Statements like this usually translate as "it does not benefit healthy subjects". This is, unfortunately, a recurrent theme in contemporary DNA repair.

[liorrh]

: J Dermatol Sci. 2005 Aug;39(2):81-8.

UV-specific DNA repair recombinant fusion enzyme: a new stable pharmacologically active principle suitable for photoprotection.

Basilico G, Roger CA, Seigelchifer M, Kerner N.

Laboratorio de Medicina Molecular, Fundacion Pablo Cassara, Buenos Aires, Argentina.

BACKGROUND: UV radiation can produce mutations in skin cells and correlates strongly with the onset of actinic keratoses and basal and squamous cell carcinomas. Xeroderma pigmentosum (XP) is a heritable disease characterized by an extreme sensitivity of skin to UV radiation. Recently, studies in cultured cells as well as in XP patients have demonstrated that the recombinant T4 endonuclease V UV-specific endonuclease could enhance repair of UV-induced photoproducts. OBJECTIVE: We aimed to obtain a stable UV-specific DNA recombinant endonuclease, pharmacologically active in mammalian cells so as to be used in treatment and prophylaxis of sun damage. METHODS: The UV-specific DNA endonuclease gene obtained from Micrococcus luteus, was fused to a leader peptide and expressed (alphaUveA), refolded and purified. A construction under the control of an eukaryotic promoter was used to transfect XP fibroblasts deficient in DNA damage repair. Transformed cells were UV irradiated and cell survival was assessed. RESULTS: alphaUveA was obtained as a highly active UV-specific repair enzyme stable for at least 2 years. XP fibroblasts transfected with alphaUveA gene increased the resistance to UV radiation and, in consequence, cell survival. CONCLUSION: alphaUveA is stable and pharmacologically active in human cells. The topical administration of this long-term stable new active principle could help diminish the risks of skin cancer after sun exposure.

PMID: 16055003

[zorba990]

Where is it?

http://www.medicalne...icles/81602.php

any sources?

[niner]

Where is it?

http://www.medicalne...icles/81602.php

any sources?

According to Dealipedia, AGI Dermatics was acquired by Estee Lauder, announced Sept. 29, 2008. Fast Track is a pretty good sign that the FDA likes it. It shouldn't be tooooo long. I would expect it to be a prescription product and to be expensive as hell. We'll see, though. You might try inquiring at EL. If you don't have Xeroderma Pigmentosum, it might not do you all that much good, seeing as you already have thymine dimer repair capability, but it's probably worth looking into.

[zorba990]

Bumping this up, any word on release of this?