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Scientists discover key driver of human aging: May lead to slowing or reversing aging process

aging

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#1 Florian Xavier

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Posted 30 April 2015 - 07:48 PM


http://www.scienceda...50430141803.htm

 

random links that are related :

 

http://www.ncbi.nlm....les/PMC2773834/

http://www.nature.co...bs/nrm2944.html " Hutchinson–Gilford progeria syndrome, have implicated molecular changes that are also linked to normal ageing, such as genome instability, telomere attrition, premature senescence and defective stem cell homeostasis in disease development. "

http://www.ncbi.nlm....pubmed/23700717

http://www.tandfonli...10#.VUKG0iHtmko

 

and more : https://scholar.goog...432460290953939


Edited by Florian Xavier, 30 April 2015 - 07:52 PM.


#2 Florian Xavier

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Posted 01 May 2015 - 09:28 AM

http://www.ncbi.nlm....les/PMC3690839/

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

http://www.ncbi.nlm....pubmed/15750587

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.

 

RB1 family and stat5a good candidates

 

 

 

PD-0332991 / Palbociclib may stabilize rb-family 

 

http://en.wikipedia....ki/Palbociclib 

 

http://www.ncbi.nlm....les/PMC2822892/

 

this : http://en.wikipedia....i/Fostamatinib 

 

http://genome.wustl....hood-eye-tumor/


Edited by Florian Xavier, 01 May 2015 - 09:57 AM.

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#3 Florian Xavier

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Posted 01 May 2015 - 06:06 PM

“It’s clear that when you have alterations in [chromosome stability], the process of aging goes so quickly and so fast that it’s tempting to say, yes, this is the key process for driving aging,” says Belmonte.

 

http://time.com/3841...ng-cells-young/







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