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Antero Grade Memory Loss, and cognitive issues in general

memory cfs hypoglycemia hormones

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#1 AlexCanada

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Posted 01 May 2015 - 09:42 PM


Ever since damage done to me over a decade ago from Accutane and ECT I have had severe long term memory issues. Great difficulty retaining new memories. Whatever experiences I have had over the past 12 years are a blur. Any relationships, friendships, joys, hardships... they would be buried away somewhere and difficult to access. Once in a rare while I have some subtle retention here and there depending what supplements/meds I am taking or time of day, but overall it's a very amensia-like existence. 

 

For instance. I just recently started watching some old seasons of Survivor as a means to try and entertain myself as I work on my issues with deep anhedonia, low energy, melancholic depression, negativity, and low estrogen + low testosterone issues.  And while I watched so many of these before over the years I cannot remember any of the winners. I would start a season and it all seems so fresh to me. Except the one season which I watched (the first) before Accutane and before ECT. Everything else would be a huge blur. This is just an example though. If I didn't constantly write things down I would be absolutely lost in the world. There is a girl I loved so immensely about 5 years ago and I honestly have intense difficulty remembering hardly Anything we ever did together during the many times we were together, nor can I hardly remember anything about her as a person. I have a general perception of people which I can recall but specific events are sometimes impossible. We shared so many memories but these are not memories I am able to recall. It is brutal. 

 

 

Excuse my not so intelligent style of writing. I had taken some gabapentin and it helps makes me social but makes me feel significantly less intelligible. 

 

 

What options do I have to improve my long term memory retention?  Glutamate enhancement?   Racetams I do not enjoy as they slow down time perception to a crawl in me usually.   

 

Furthermore I develop intense short term memory issues while standing or physically exerting myself. This may relate to orthostatic intolerance as my pulse goes from 60 to 110 while standing and I tend to feel dizzy and reallyyy worn out if I am standing for a bit too long. Surely some circulation issues. I could be at the grocery store and know what I want to buy and then everything gets muddy rapidly. Foggy, and my information processing slows down intensely. Becomes so difficult to read. This may be due to adrenal exhaustion as I have low cortisol but Chronic Fatigue Syndrome symptoms I have had for years. Not to mention possible hypoglycemia, dehydration, or blood sugar fluctuations. Cognitive issues with me have been severe in general and I would just like any advice on how I can improve myself.  I honestly find it difficult to even communicate with people on a basic level much of the time. The time when my mind flows most freely is usually when I am sitting in the shower and the water is flowing around me. My body's circulation I assume improves in this state and things just come much more naturally to me. Then I quickly get worn out mentally once I am out of the shower. Back to feeling like a slow minded zombie with no interests.  


Edited by AlexCanada, 01 May 2015 - 09:44 PM.


#2 OneScrewLoose

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Posted 04 May 2015 - 03:25 AM

This is just anecdotal, but Zonisamide restored pieces of me that I thought were gone forever due to trauma. It was at doses over 400mg that this worked. It's a pretty heavy-duty medication. I could barely eat on it, but when I went off, those pieces were still there.

This is not a common recommendation, but I recommend a low-moderate dose of Prozac. It's actually a rather light SSRI, instead also working by blocking 5HT2c receptors, which increases dopamine in the Ventral Tegmental Area of the brain, one of the two main pleasure centers, like agomelatine does. I personally believe that Prozac is one of the, if not thee best, SSRI, that just unfortunately received a ton of stigma.

Modafinil/Armodafinil may be a potential help, as they are only minor stimulants and are instead wakefulness.

The otc supplement Yohimbine is a alpha 2 antagonist, which increases norepinephrine and can increase energy dramatically.

Adrenal Fatigue is an unscientific catch-all in various online forums, for which, IMHO, there exists no evidence for it as a coherent, singular disease. It's just a collection of related symptoms that may have related solutions.

 

But honestly, this looks like it may be a case of depersonalization/derealization. Look into this and tell me your opinion of it.


Edited by OneScrewLoose, 04 May 2015 - 03:27 AM.

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#3 AlexCanada

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Posted 02 June 2015 - 02:15 AM

This is just anecdotal, but Zonisamide restored pieces of me that I thought were gone forever due to trauma. It was at doses over 400mg that this worked. It's a pretty heavy-duty medication. I could barely eat on it, but when I went off, those pieces were still there.

This is not a common recommendation, but I recommend a low-moderate dose of Prozac. It's actually a rather light SSRI, instead also working by blocking 5HT2c receptors, which increases dopamine in the Ventral Tegmental Area of the brain, one of the two main pleasure centers, like agomelatine does. I personally believe that Prozac is one of the, if not thee best, SSRI, that just unfortunately received a ton of stigma.

Modafinil/Armodafinil may be a potential help, as they are only minor stimulants and are instead wakefulness.

The otc supplement Yohimbine is a alpha 2 antagonist, which increases norepinephrine and can increase energy dramatically.

Adrenal Fatigue is an unscientific catch-all in various online forums, for which, IMHO, there exists no evidence for it as a coherent, singular disease. It's just a collection of related symptoms that may have related solutions.

 

But honestly, this looks like it may be a case of depersonalization/derealization. Look into this and tell me your opinion of it.

 

I don't believe it relates to depersonalization but I may have experienced some of that on memantine years ago.

 

 

Yohimbine I tried several days ago for few days. Energy was no worse, if anything it was bit better. Was difficult to tell as various factors were involved such as withdrawl from NSI and changes in few other substances. I did have some small emergence of interest briefly in an old video game I used to play after doing 100 jumping jacks few hours after Yohimbine 5mg dose.   Mine is likely a cheap brand. I got it for $5 off ebay. Yohimbine extract. I likely will try again but will be careful what I mix with since tomorrow I likely will have Atomoxetine.  Thank you btw. It was your suggestion I believe which led me to trying yohimbine in the first place. 

 

modafinil is huge help btw! But I cannot take it anymore due to severe rash reactions on my face. Even low dose caused this. I used to be able to take it without issue.  Modafinil used to really allow me to get things done. Not necessarily help much for depression but for motivation/energy + alertness it was a very obvious benefit in some regards. 

 

Prozac may be worth a try down the road. I actually was meant to take it months ago but they lost my bottle at the hospital! I had liquid form of the drug. 

 

Agomelatine I have on me personally. This is something worth investigating but infomation is difficult to find. May be a much better option than seroquel.  Does it in theory upregulate or modulate dopamine as well? Or have any effects on cortisol and blood sugar?

 

 

PAWS for benzo withdrawal may be one of my big factors overall in regards to cognitive issues. But as I slowly withdrawl from 1.2mg valium (1.6mg 3 months ago) I don't want my life put on hold. I feel such apathy these days. I am noticing I am having less stress response, more able to handle stress the past 2 months but very apathetic overall and feeling oddly as if i am not fully awake. I don't feel connected necessarily to what is really around me. 


Edited by AlexCanada, 02 June 2015 - 02:56 AM.


#4 AlexCanada

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Posted 10 June 2015 - 03:39 AM

Does anyone have any suggestions for anti-amnesia agents? In terms of helping me retain memories and be able to access them. 



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#5 OneScrewLoose

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Posted 13 June 2015 - 03:12 AM

 

This is just anecdotal, but Zonisamide restored pieces of me that I thought were gone forever due to trauma. It was at doses over 400mg that this worked. It's a pretty heavy-duty medication. I could barely eat on it, but when I went off, those pieces were still there.

This is not a common recommendation, but I recommend a low-moderate dose of Prozac. It's actually a rather light SSRI, instead also working by blocking 5HT2c receptors, which increases dopamine in the Ventral Tegmental Area of the brain, one of the two main pleasure centers, like agomelatine does. I personally believe that Prozac is one of the, if not thee best, SSRI, that just unfortunately received a ton of stigma.

Modafinil/Armodafinil may be a potential help, as they are only minor stimulants and are instead wakefulness.

The otc supplement Yohimbine is a alpha 2 antagonist, which increases norepinephrine and can increase energy dramatically.

Adrenal Fatigue is an unscientific catch-all in various online forums, for which, IMHO, there exists no evidence for it as a coherent, singular disease. It's just a collection of related symptoms that may have related solutions.

 

But honestly, this looks like it may be a case of depersonalization/derealization. Look into this and tell me your opinion of it.

 

I don't believe it relates to depersonalization but I may have experienced some of that on memantine years ago.

 

Why is that?

 

Yohimbine I tried several days ago for few days. Energy was no worse, if anything it was bit better. Was difficult to tell as various factors were involved such as withdrawl from NSI and changes in few other substances. I did have some small emergence of interest briefly in an old video game I used to play after doing 100 jumping jacks few hours after Yohimbine 5mg dose.   Mine is likely a cheap brand. I got it for $5 off ebay. Yohimbine extract. I likely will try again but will be careful what I mix with since tomorrow I likely will have Atomoxetine.  Thank you btw. It was your suggestion I believe which led me to trying yohimbine in the first place. 

 

Every substance needs to be tried from a scientific approach. That means, with as few variables as possible. Try the Yohimbine again, starting at 2.5mg, when you are not changing anything else. You're welcome, btw.

 

modafinil is huge help btw! But I cannot take it anymore due to severe rash reactions on my face. Even low dose caused this. I used to be able to take it without issue.  Modafinil used to really allow me to get things done. Not necessarily help much for depression but for motivation/energy + alertness it was a very obvious benefit in some regards. 

 

What kind of rash? How long after modafinil did it start? What dose were you on?

 

Prozac may be worth a try down the road. I actually was meant to take it months ago but they lost my bottle at the hospital! I had liquid form of the drug. 

 

I didn't know they made a liquid form.

 

Agomelatine I have on me personally. This is something worth investigating but infomation is difficult to find. May be a much better option than seroquel.  Does it in theory upregulate or modulate dopamine as well? Or have any effects on cortisol and blood sugar?

 

It is nothing like Seroquel. It agonizes melatonin receptors and antagonizes 5ht2c receptors, in the same way Prozac does. As I said, this increase the release of dopamine in the Ventral Tegmental Area, and thus modulates dopamine. It has no effects on cortisol or blood sugar, but can have effects on certain important liver enzymes that do need to be monitored periodically.

 

 

PAWS for benzo withdrawal may be one of my big factors overall in regards to cognitive issues. But as I slowly withdrawl from 1.2mg valium (1.6mg 3 months ago) I don't want my life put on hold. I feel such apathy these days. I am noticing I am having less stress response, more able to handle stress the past 2 months but very apathetic overall and feeling oddly as if i am not fully awake. I don't feel connected necessarily to what is really around me. 

Try a z-drug, like Ambien or Sonata at night. They work on the same benzodiazapine site as the benzos themselves, but in quite a different way. This might modulate any withdrawal and even help you reduce it.

 

Does anyone have any suggestions for anti-amnesia agents? In terms of helping me retain memories and be able to access them.


I wouldn't call it amnesia, but for memory issues, like into the racetams + choline. You need to take the choline with it as it increases acetylcholine production, one of the principle neurotransmitters involved in memory. I would start with Piracetam:

http://peaknootropic...shop/piracetam/

and just regular choline bitartrate.





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