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C60 in Cyclodextrin for liver injury induced by acetaminophen

c60 cyclodextrin liver acetaminophen

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#1 Anthony_Loera

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Posted 03 May 2015 - 12:47 AM


Just something I ran into today... c60 in cyclodextrin helps liver injury.

 

Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen

 

Abstract

Stable hydrophilic C60(OH)10 nanoparticles were prepared from 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and applied to the treatment of an acetaminophen overdose induced liver Injury. C60(OH)10 nanoparticles were produced by cogrinding α-CD, β-CD, γ-CD and HP-β-CD and characterized in terms of solubility, mean particle diameter, ζ-potential and long term dispersibility in water. Hydrophilic C60(OH)10 nanoparticles with particle sizes less than 50 nm were effectively produced by cogrinding HP-β-CD with C60(OH)10 at a molar ratio of 1:3 (C60(OH)10:CD).

 

The resulting C60(OH)10/HP-β-CD nanoparticles were stable in water and showed no aggregation over a 1 month period. The C60(OH)10/CDs nanoparticles scavenged not only free radicals (DPPH and ABTS radicals) but also reactive oxygen species (O2(•-) and •OH).

 

When C60(OH)10/HP-β-CD nanoparticles were intraperitoneally administered to mice with a liver injury induced by an overdose of acetaminophen (APAP), the ALT and AST levels were markedly reduced to almost the same level as that for normal mice. Furthermore, the administration of the nanoparticles prolonged the survival rate of liver injured mice, while all of the mice that were treated with APAP died within 40 h.

 

To reveal the mechanism responsible for liver protection by C60(OH)10 nanoparticles, GSH level, CYP2E1 expression and peroxynitrite formation in the liver were assessed. C60(OH)10/HP-β-CD nanoparticles had no effect on CYP2E1 expression and GSH depletion, but suppressed the generation of peroxynitrite in the liver.

 

The findings indicate that the protective effect of C60(OH)10/HP-β-CD nanoparticles was due to the suppression of oxidative stress in mitochondria, as the result of scavenging ROS such as O2(•-), NO and peroxynitrite, which act as critical mediators in the liver injuries.

 

From: http://www.ncbi.nlm....pubmed/25662501

 

 

Cheers

A


Edited by Anthony_Loera, 03 May 2015 - 12:49 AM.

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#2 APBT

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Posted 03 May 2015 - 06:04 PM

FULL TEXT:

Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen

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Click HERE to rent this advertising spot for C60 HEALTH to support Longecity (this will replace the google ad above).

#3 jroseland

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Posted 13 February 2019 - 02:43 PM

What is cyclodextrin? Can we assume that normal C60/EVOO would have the same effect?



#4 Rocket

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Posted 14 February 2019 - 07:56 PM

Be cautious as cyclodextrin can cause hearing damage.


Edited by Rocket, 14 February 2019 - 07:57 PM.

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