26 replies to this topic

[Florian Xavier]

Glucosamine + ibuprofen arginine

 

WHY ?

 

Glucosamine is the only compound that is proven to extend life of humans, and decrease the incidence of cancer

 

Ibuprofen arginine is a pain killer, decreasing pain receptors extend life in mouse and chronic pain decrease it in humans. Ibuprofen decrease cancer incidence and depression too. Arginine decrease greatly the risk of gastro intestinal bleeding.

 

In addition, Glucosamine + ibuprofen arginine symbiose to make a good pain-killer :

 

http://www.scienceda...40108080849.htm

 

So i think about realy taking this. I think is it the best you can do in regard to aging right now.

 

Less pain, less cancer, and an increased lifespan.

Edited by Florian Xavier, 05 May 2015 - 11:20 PM.

[OneScrewLoose]

Glucosamine is the only compound that is proven to extend life of humans, and decrease the incidence of cancer

 

[citation needed]

[Florian Xavier]

http://www.ncbi.nlm....pubmed/22828954

 

Use of glucosamine with or without chondroitin was associated with reduced total mortality and with reductions of several broad causes of death. Although bias cannot be ruled out, these results suggest that glucosamine may provide some mortality benefit.

 

http://ajcn.nutritio...6/1791.abstract

 

For most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased total mortality.

 

Only problem : longevity effect is absent when feeded with antioxidants like NAC, i wonder if ibuprofen is an antioxidant.

 

http://www.nature.co...ncomms4563.html

 

"To test whether the increase in ROS is essential for a GlcN [glucosamine]-mediated extension of life span, we repeated the initial life span experiment in the presence of the antioxidants butylated hydroxy anisole (BHA) and N-acetyl-cystein (NAC), respectively. Although neither BHA nor NAC had a detectable effect on C. elegans life span in the absence of GlcN, the life span-extending capabilities of GlcN were nullified in the presence of BHA or NAC"

 

This site think otherwise :

 

The study authors believe that anti- oxidants interfere with glucosamine life span extension. We don’t

 

http://www.life-enha...st-in-longevity

 

Humans who took glucosamine + chondrointe wich is an antioxidant still saw their lifespan increased.

 

http://www.ncbi.nlm....pubmed/17168807

 

Do ibuproen act as a pro or anti oxidant ? 

 

http://ar.basmedcol....-Jawad-2009.pdf

 

Edited by Florian Xavier, 05 May 2015 - 11:54 PM.

[niner]

 

Glucosamine is the only compound that is proven to extend life of humans, and decrease the incidence of cancer

 

 

Only?  Proven?  What about Rapamycin, Metformin, Actonel?  What exactly is the standard of evidence here?

[OneScrewLoose]

http://www.ncbi.nlm....pubmed/22828954

 

Use of glucosamine with or without chondroitin was associated with reduced total mortality and with reductions of several broad causes of death. Although bias cannot be ruled out, these results suggest that glucosamine may provide some mortality benefit.

 

http://ajcn.nutritio...6/1791.abstract

 

For most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased total mortality.

 

Only problem : longevity effect is absent when feeded with antioxidants like NAC, i wonder if ibuprofen is an antioxidant.

 

http://www.nature.co...ncomms4563.html

 

"To test whether the increase in ROS is essential for a GlcN [glucosamine]-mediated extension of life span, we repeated the initial life span experiment in the presence of the antioxidants butylated hydroxy anisole (BHA) and N-acetyl-cystein (NAC), respectively. Although neither BHA nor NAC had a detectable effect on C. elegans life span in the absence of GlcN, the life span-extending capabilities of GlcN were nullified in the presence of BHA or NAC"

 

This site think otherwise :

 

The study authors believe that anti- oxidants interfere with glucosamine life span extension. We don’t

 

http://www.life-enha...st-in-longevity

 

Humans who took glucosamine + chondrointe wich is an antioxidant still saw their lifespan increased.

 

http://www.ncbi.nlm....pubmed/17168807

 

Do ibuproen act as a pro or anti oxidant ? 

 

http://ar.basmedcol....-Jawad-2009.pdf

 

Interesante, I'll definitely have to take a look, just a bit tired right now from PubMed overload. But to whomever gave me that negative rating to my post asking for a source, fuck you, that is the motherfucking heart of science.

Also, it certainly wouldn't be the only thing. Drinking 3+ glass of green tea per day has shown to extend lifespan by an average of 5 years. This doesn't mean the supplemental extracts do the same, fyi.

http://www.sciencedi...047279709001653

I know it's a longitudinal study, and therefore has its limitations, but there is evidence that drinking green tea can have a variety of benefits.

[Florian Xavier]

personaly i dn't buy into green tea, not even melatonin.

 

Plus this combination seems to supress some pain of life, including neuropathic pain.

 

only high dose of IBU increase cvd : http://www.ncbi.nlm....pubmed/21980265

 

Moreover, the use of low-dose ibuprofen is known to be associated with a very low incidence of serious gastrointestinal toxicity, and arginine protect greatly against it.

Edited by Florian Xavier, 06 May 2015 - 07:00 AM.

[Florian Xavier]

We need to test glucosamine + ibuprogen arginine on ageing mouses :

 

 http://www.nature.co...ncomms4563.html

 

Anyone can try it ?

[Florian Xavier]

 

 

Glucosamine is the only compound that is proven to extend life of humans, and decrease the incidence of cancer

 

 

Only?  Proven?  What about Rapamycin, Metformin, Actonel?  What exactly is the standard of evidence here?

 

 

 

Yeah but rapamycin is not safe to use, and no evidences of lifespan improvments in humans with metformin and actonel.

[Florian Xavier]

ibuprofen itself increase lifespan, maybe there is a magic synergy between glucosamine and ibuprofene arginine, a trial on rats is warranted.

 

http://www.ncbi.nlm....pubmed/25521617

Edited by Florian Xavier, 06 May 2015 - 12:18 PM.

[Florian Xavier]

http://pipeline.cora..._down_aging.php

[Florian Xavier]

If there is a synergy with PAIN maybe there is a synergy with aging too, since pain is a component of aging.

 

http://healthwitz.co...p/article/41211

 

there is a good chance.

 

Trials are warranted on mice or rats.

Edited by Florian Xavier, 06 May 2015 - 05:09 PM.

[Logic]

 

 

Glucosamine is the only compound that is proven to extend life of humans, and decrease the incidence of cancer

 

 

Only?  Proven?  What about Rapamycin, Metformin, Actonel?  What exactly is the standard of evidence here?

 

 

...40 mg/kg of pterostilbene...were comparable to the experimental effects of 500 mg/kg oral metformin...

...Zhang and colleagues have demonstrated that pterostilbene treatment induces autophagy in oxLDL-stimulated VECs through activation of AMP-activated protein kinase (AMPK), intracellular calcium (Ca2+), and mammalian target of rapamycin (mTOR) signaling...

http://www.hindawi.c...cl/2013/575482/

 

[niner]

...40 mg/kg of pterostilbene...were comparable to the experimental effects of 500 mg/kg oral metformin...

 

At current prices, that would cost me about 12 USD/day for the pterostilbene.  That much metformin would probably make a person barf...  That's a huge dose of metformin.  Does that mean that you could maybe take 100-200mg/day of pterostilbene and have it work as well as a normal (~2g/d) metformin dose?  That would be nice. Chromadex has the pterostilbene market sewed up, just like with NR.

[Logic]

At current prices, that would cost me about 12 USD/day for the pterostilbene.  That much metformin would probably make a person barf...  That's a huge dose of metformin.  Does that mean that you could maybe take 100-200mg/day of pterostilbene and have it work as well as a normal (~2g/d) metformin dose?  That would be nice. Chromadex has the pterostilbene market sewed up, just like with NR.

Pterostilbene does seem to hav the same effect as a huge dose of Metformin, but the study was done in Rats IIRC and need to be read.

HED needs to be worked out too.

 

Chromadex better get their heads out the clouds:  The Chinese are starting to produce these.  I have just seen both P and NR on a price list from what I believe to be a reputable? supplier.

[OneScrewLoose]

No offense, but you seem to be obsessed with Glucosamine + Ibuprofen, as if it's the next miracle drug/combination, and discount virtually anything else. May I ask why this is?

Edited by OneScrewLoose, 07 May 2015 - 08:20 AM.

[Florian Xavier]

Because glucosamine and ibuprofen bot extend life span, gluc in humans, as well as decreasing synergetically pain.

[niner]

Because glucosamine and ibuprofen bot extend life span, gluc in humans, as well as decreasing synergetically pain.

 

And this claim is a reason to ignore all other substances?  I'm still wondering what your standard of evidence is...  Ibuprofen is an anti-inflammatory, so it will cut down on many (but not all) sources of pain, but it also kills people from GI bleeds. 

[OneScrewLoose]

Because glucosamine and ibuprofen bot extend life span, gluc in humans, as well as decreasing synergetically pain.

 

Selegiline has a good chance of increasing lifespan more than any other drug so far (except perhaps Vitamin D). CBD can drastically reduce pain, especially neuropathic in some people. Many racetams increase glutaminergic activity. Cissus can drastically reduce joint pain. Baclofen, a pharmaceutical, can drastically reduce pain in some.

 

I'm not disagreeing with you or your hypothesis, I haven't looked into  it enough yet to agree nor disagree. I'm just saying, there's a huge world of supplements out there, and you should get acquainted with the options. The supps I just mentioned would work in addition to Glucosamine and Ibuprofen. It's a wonderful world out there! Why restrict yourself?

But thanks for the info,  I'll definitely take a look.

Edited by OneScrewLoose, 07 May 2015 - 07:40 PM.

[Logic]

Selegiline has a good chance of increasing lifespan more than any other drug so far (except perhaps Vitamin D). CBD can drastically reduce pain, especially neuropathic in some people. Many racetams increase glutaminergic activity. Cissus can drastically reduce joint pain. Baclofen, a pharmaceutical, can drastically reduce pain in some.
 
I'm not disagreeing with you or your hypothesis, I haven't looked into  it enough yet to agree nor disagree. I'm just saying, there's a huge world of supplements out there, and you should get acquainted with the options. The supps I just mentioned would work in addition to Glucosamine and Ibuprofen. It's a wonderful world out there! Why restrict yourself?

But thanks for the info,  I'll definitely take a look.

Agreed.

Its also why I brought up Pterostilbene which has similar effects to 2 of the proven human life extenders Florian Xavier.

Also look at C60oo as a 90% lifespan increase from only 24 doses and dosing stopped when the control rats died is the closest to 'One Substance to rule them all' we have atm, IMHO.
 

[Florian Xavier]

It is just false. Glucosamine and perhaps ibuprofen arginine is the only safe combination that delay aging and the consequences so far in humans.

[Florian Xavier]

 

Because glucosamine and ibuprofen bot extend life span, gluc in humans, as well as decreasing synergetically pain.

 

And this claim is a reason to ignore all other substances?  I'm still wondering what your standard of evidence is...  Ibuprofen is an anti-inflammatory, so it will cut down on many (but not all) sources of pain, but it also kills people from GI bleeds. 

 

 

not with arginine.

[OneScrewLoose]

It is just false. Glucosamine and perhaps ibuprofen arginine is the only safe combination that delay aging and the consequences so far in humans.

Well, I'm gonna pick my jaw up from the floor, and tell you I have really nothing to say about that. Kinda frozen here. Good luck with your endeavours and I hope you get to spend some quality time on this forum.

[normalizing]

onescrewloose was actually open minded about this more so than anyone else reading this thread and yet, you lost even him now :(

[Florian Xavier]

you can't disagree if there is no trials.

[niner]

you can't disagree if there is no trials.

 

Oh come on.  Ibuprofen produced modest life extension in yeast, worms, and flies.  So do a lot of things.  It's easy to make simple organisms live longer.  At least c60oo has results in a mammal, and they are more impressive than the ibuprofen results in lower organisms.  It's likely that none of these will show the same magnitude of effect in humans, though.  At least with metformin and actonel, there is epidemiologic evidence for life extension in humans.  Is there such evidence for ibuprofen in humans?

[niner]

Epidemiological evidence for bisphosphonate (Actonel, Fosamax, etc) life extension: http://www.eurekaler...a-ae5020111.php

Rodent evidence for metformin.  There's some human epidemiology on it out there somewhere...

 

[OneScrewLoose]

I feel iike this is just some hardcore trolling. This can't be real.