I feel you man.
Psychedelics are like the unique key that fits into this lock and nothing else quite works so well. To have feeling restored, to go from dissociation to a clear sense of self and purpose, to go from a dull world to one filled with excitement. Other substances can motivate you, they can give you some of that feeling back, make a few things brighter, but nothing is quite as clean of a fix as a trip. For you and me, a psychedelic trip is a foray into normality instead of the godhead.
I haven't found an acceptable solution yet, so I'm still looking for a way to make normal an everyday feeling.
I'll say that meditation definitely helps. It doesn't get you all the way there, but it fixes a lot. That said, the benefits are lost when you stop meditating on a regular basis.
For substances, certain psychedelics offer hope.
For one thing, there is DMT. Studies report not tolerance build up. But there's a caveat. DMT is very short-acting compared to other tryptamines. If you were to attempt to use it as a 'medicine' throughout the day, you may very well see the same kind of tolerance build up that longer-acting tryptamines have. If you check out the nexus, you'll hear that people do get a little tolerance to ayahuasca after several consecutive days.
Another possibility is phenethylamines. There are even papers claiming that mescaline does not produce tolerance. Various users have said that it does result in tolerance, though. But there is the possibility that the tolerance build-up is sufficiently small that, at least microdosing is possible. LSD isn't great for microdosing, but psychedelics that are could produce cumulative effects with time.
At the end of the day, the magic of psychedelics is probably glutamate release. I guess that can be said for a lot of things, but there is evidence that the key receptor at play is the mglur2 receptor so there is a specific target for you. It is an inhibitory receptor and the 5-HT2A-mglur2 heterodimer results in a decrease in activity at mglur2. You could try an mglur2 antagonist, which would be some strangely-named research chemical. You could try substances that increase activity at the other Mglu receptors. Maybe ampakines could be helpful, too. The effects described seem to mirror psychedelic effects to a degree.
These are just possible solutions that I've thought about. Nothing here is safe. Mess with glutamate and you risk literally frying your brain with excitotoxicity. Weekly LSD is potentially dangerous. While it has not been proven to be neurotoxic, here is something to be concerned about. Granted, they claim this to model schizophrenia in animals and the effects seem nothing like what schizophrenics experience (aside from the social withdrawal). Who knows what could happen if you use some psychedelic daily. But few risks seem too great when you live like a soul-less lump of flesh.
Edited by burnlife, 24 May 2015 - 04:50 AM.