Mol Cell Endocrinol. 2015 May 11. pii: S0303-7207(15)00240-3.
Dehydroabietic Acid is Anti-Aging and Activates SIRT1
#1
Posted 23 May 2015 - 04:56 PM
#2
Posted 23 May 2015 - 10:04 PM
- Biofactors. 2010 May-Jun;36(3):240.
Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK-Ay mice. We showed here that DAA treatment decreased not only plasma glucose and insulin levels but also plasma triglyceride (TG) and hepatic TG levels. To examine the mechanism underlying the effects of DAA, the production of inflammatory cytokines was measured. It was shown that the DAA treatment suppressed the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNFalpha) (proinflammatory cytokines) and increased that of adiponectin (an anti-inflammatory cytokine). As a result of the changes in the production of inflammatory cytokines caused by the DAA treatment, the accumulation of macrophages in adipose tissues was reduced. These results indicate that treatment with DAA improves the levels of plasma glucose, plasma insulin, plasma TG, and hepatic TG through the decrease in the macrophage infiltration into adipose tissues, suggesting that DAA is a useful food-derived compound for treating obesity-related diseases.
Copyright 2009 International Union of Biochemistry and Molecular Biology, Inc.
#3
Posted 25 May 2015 - 07:44 PM
Alas, dehydroabietic acid is also a fairly potent cytotoxin at doses greater than 10 μg/mL, with most studies being on DAA pollution in wood mill effluent.
Söderberg, T. A., Johansson, A., & Gref, R. (1996). Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells.Toxicology, 107(2), 99-109.
Little is known about food content, but wheat flour is highest, with 503 ± 39 ng/g.
Mitani, K., Fujioka, M., Uchida, A., & Kataoka, H. (2007). Analysis of abietic acid and dehydroabietic acid in food samples by in-tube solid-phase microextraction coupled with LCMS.Journal of chromatography A, 1146(1), 61-66.
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