• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

Dehydroabietic Acid is Anti-Aging and Activates SIRT1

dehydroabietic acid

  • Please log in to reply
2 replies to this topic

#1 ta5

  • Guest
  • 952 posts
  • 324
  • Location: 

Posted 23 May 2015 - 04:56 PM


Mol Cell Endocrinol. 2015 May 11. pii: S0303-7207(15)00240-3.

Kim J1, Kang YG2, Lee JY3, Choi DH4, Cho YU5, et al.
Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid of confers, such as pinus species (P. densiflora, P. sylvestris) and grand fir (A. grandis), and it induces various biological actions including antimicrobial, antiulcer, and cardiovascular activities. The cellular targets that mediate these actions are largely unknown yet. In this report, we suggest that DAA is an anti-aging reagent. DAA has lifespan extension effects in C. elegans, prevents lipofuscin accumulation, and prevents collagen secretion in human dermal fibroblasts. We found that these anti-aging effects are primarily mediated by SIRT1 activation. Lifespan extension effects by DAA were ameliorated in sir-2.1 mutants and SIRT1 protein expression was increased, resulting in the deacetylation of SIRT1 target protein PGC-1α. Moreover, DAA binds directly to the SIRT1 protein independent of the SIRT1 substrate NAD+ levels. Through a molecular docking study, we also propose a binding model for DAA-SIRT1. Taken together, our results demonstrate that the anti-aging effects are the first identified biological property of DAA and that the direct activation of SIRT1 enzymatic activity suggests the potential use of this natural diterpene, or related compounds, in age-related diseases or as a preventive reagent against the aging process.
PMID: 25976661

  • like x 1

#2 tintinet

  • Guest
  • 1,972 posts
  • 503
  • Location:ME

Posted 23 May 2015 - 10:04 PM

Biofactors. 2009 Sep-Oct;35(5):442-8. doi: 10.1002/biof.58.
Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.
Erratum in
  • Biofactors. 2010 May-Jun;36(3):240.
Abstract

Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK-Ay mice. We showed here that DAA treatment decreased not only plasma glucose and insulin levels but also plasma triglyceride (TG) and hepatic TG levels. To examine the mechanism underlying the effects of DAA, the production of inflammatory cytokines was measured. It was shown that the DAA treatment suppressed the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNFalpha) (proinflammatory cytokines) and increased that of adiponectin (an anti-inflammatory cytokine). As a result of the changes in the production of inflammatory cytokines caused by the DAA treatment, the accumulation of macrophages in adipose tissues was reduced. These results indicate that treatment with DAA improves the levels of plasma glucose, plasma insulin, plasma TG, and hepatic TG through the decrease in the macrophage infiltration into adipose tissues, suggesting that DAA is a useful food-derived compound for treating obesity-related diseases.

Copyright 2009 International Union of Biochemistry and Molecular Biology, Inc.

PMID:   19753653   [PubMed - indexed for MEDLINE]

 


  • like x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#3 Darryl

  • Guest
  • 650 posts
  • 657
  • Location:New Orleans
  • NO

Posted 25 May 2015 - 07:44 PM

Alas, dehydroabietic acid is also a fairly potent cytotoxin at doses greater than 10 μg/mL, with most studies being on DAA pollution in wood mill effluent.

 

Söderberg, T. A., Johansson, A., & Gref, R. (1996). Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells.Toxicology107(2), 99-109.

 

Little is known about food content, but wheat flour is highest, with 503 ± 39 ng/g.

 

Mitani, K., Fujioka, M., Uchida, A., & Kataoka, H. (2007). Analysis of abietic acid and dehydroabietic acid in food samples by in-tube solid-phase microextraction coupled with LCMS.Journal of chromatography A1146(1), 61-66.

 

 






1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users