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Medications for improving empathy + kindness + friendliness?

depression anhedonia empathy

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#31 VerdeGo

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Posted 06 June 2015 - 04:46 AM

Interesting stuff. I just ordered valerian, roman chamomile, ylang ylang, patchouli, clary sage, and melissa (lemon balm). Jasmine and rose will be purchased next time. I already possess frankincense, but I haven't used it yet. Same with peppermint. A friend swears by frankincense, and claims it opens up spiritual channels. I guess each person has their own favorites that appeal to them the most. For me, I'm just getting started, but I'm still blown away that by inhaling the aroma of an oil, I can get psychoactive effects (not even touching on topical application, though I apply lavender and oregano that way). Good stuff.

 

I'll have to check out Ananda Apothecary and Young Living. Thanks for the suggestions. 

 

Eon, what was your impression of lemon balm oil? I've learned that it blocks the breakdown of GABA, while lavender blocks the binding of glutamate. Two different approaches for similar outcomes of stress relief. I've already tried lemon balm tea and found it slightly stimulating and relaxing in the same token. I'm assuming the oil will be the best way of experiencing the nature of this plant. Any further advice, suggestions, or wisdom you'd like to impart? I'm all eyes. 



#32 eon

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Posted 06 June 2015 - 09:40 AM

I've also used lemon balm (melissa) supplement. It's potent. I believe it has MAOI activity if I'm not mistaken. I know a bought it for a special reason, I still have it. The essential oil version should be a carbon copy but in another form.

 

Thyme is another special one for the GABA:

 

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor fromDrosophila melanogaster

 

http://www.ncbi.nlm....les/PMC1574153/

 

Young Living is known for expensive oils. If you had the money go for it, otherwise I think any essential oil from reputable companies will be just as good. My favorite brands are Aura Cacia, Ananda Apothecary, NOW, Nature's Alchemy, etc. Sometimes you can get these oils cheaper on Swanson vitamins website and pureformulas.com which is why I was able to get as much as 2 dozen different oils. Dr. Vita has some good prices as well.

 

I'd have to look more into Helichrysum, I think someone on Ananda's website forum has mentioned it makes your vision better when rubbed on the bone under the eye? Haven't tried yet. I've finished 2 bottles of peppermint already. I think the reason why I used it was for its energizing effect. I think it worked, but also the menthol in peppermint is known to have an effect on the kappa-opoioid receptor, but not as strong.


Edited by eon, 06 June 2015 - 09:51 AM.


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#33 AlexCanada

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Posted 06 June 2015 - 05:54 PM

Some great suggestions in here guys. Keep it up.

 

Unless it was a coincidence I had bit more pleasant experience watching a tv show earlier this morning after sniffing some Lemon Oil. Initially I'm not sure I felt much but an hour later was bit better. May be coincidental though.  I did just start parnate few days ago 7.5mg and will work my way up towards 25mg if I can tolerate it. Unfortunately bit aggression and hostility on the onset.  



#34 VerdeGo

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Posted 07 June 2015 - 05:29 AM

Peppermint sounds a bit intriguing. I have an unopened bottle from Nature's Alchemy (also the brand of my lemon oil), and I think I may try that next. Another person on the net who favored both lemon and lavender also favored peppermint for its energizing effects. 

 

As for lemon balm, I read some conflicting reports about its harmine content. It seems to have a lower content than passionflower (I wonder what passionflower essential oil is like, must be powerful). I'm also concerned over it blocking nicotine from binding to receptors. Since I vape on a regular basis, I wonder where the excess nicotine would go? Lemon balm tea gave me uplifting yet relaxing effects. Hard to explain, though vaping didn't seem as pleasurable at the time. It synergized well with lavender, as the examine.com article stated (a very high synergy and binding to benzo receptors if I am recalling correctly). I have my doubts whether lemon balm acts as anything but a very weak MAOI, though it certainly appears to block the breakdown of GABA. Unfortunately all I could find in reference to lemon balm and MAOI are several references from forums discussing shrooms and DMT. From a post:

 

Melissa officinalis also contains 1-octen-3-ol, 10-alpha-cadinol, 3-octanol, 3-octanone, alpha-cubebene, alpha-humulene, beta-bourbonene, caffeic acid, caryophyllene, caryophyllene oxide, catechinene, chlorogenic acid, cis-3-hexenol, cis-ocimene, citral A, citral B, citronellal, copaene, delta-cadinene, eugenyl acetate, gamma-cadinene, geranial, geraniol, geranyl acetate, germacrene D,isogeranial, linalool, luteolin-7-glucoside, methylheptenone, neral, nerol, octyl benzoate, oleanolic acid, pomolic acid, protocatechuic acid, rhamnazine, rosmarinic acid, rosmarinin acid, stachyose, succinic acid, thymol, trans-ocimene and ursolic acid.

 

Also found this, and it's interesting how harmine is a fluorescent molecule that attracts bees to pollinate: http://www.jofsr.com...icle/view/30/21

 

There's also mention of smoking it for the MAOI content of harmine (though it doesn't appear to have the other harmala alkaloids), though I haven't come across anyone who has had success for this purpose with using it in the form of an essential oil. I have my doubts that inhaling lemon balm itself would provide a substantial MAOI effect and clash with other medications (I'm not on any, but I'm slightly concerned about diet/nicotine conflicting with its MoA). Any thoughts?

 

 

I decided to try lemon oil for the second time today. Two inhalations, and the effects were more subtle but still pronounced for me. My perspective seemed a lot sunnier, and I was singing to myself after about 10 minutes. The usual stress didn't affect me, and I was highly talkative. I had two friends try it, and one person noted an uplifting feeling (he had just awoken from a nap when I arrived). I observed them both, and found them to be more social and humorous. I brought it into work with me and five coworkers tried it. I observed their behavior for the rest of the evening, and I found them laughing more than usual, dancing around, and hyped up. Nobody had any complaints, and several people wanted to inhale more. One person noted the entire one side of his head was tingling after inhaling it for the second time, much like the sensations I encountered after my first, large dose two weeks ago (5-6 deep inhalations). So while the effects may be subtle, especially if you're not looking for effects, they definitely produce behavioral changes from an objective point of view. Still not scientific, but I think science has already ascertained that the effects of lemon oil are anything but spurious.

 

Alex, perhaps a diluted (1-5%) topical application of the oil would create more substantial, uplifting effects for you? I believe lemon oil is phototoxic, so if it's applied to the skin it should be in an area where sunlight doesn't hit it. I'm also not sure how dosing this way would interact with parnate. I experience enough effects from inhaling it that I have no desire to use it topically, but I imagine those effects would be more pronounced. 



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#35 eon

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Posted 07 June 2015 - 12:25 PM

I'm trying to find out what essential oil would interact with an amphetamine. I'm assuming anything stimulating would have an effect when mixed with another stimulant. 







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