There seem to be a new class of antidepressants that are NOT SSRIs and they are mostly still in development and are mostly derived from Ketamine:
New Antidepressant NRX-1074 (NMDA Receptor Modulator) In Development
"Given the current developments by the company Naurex, it seems as though we will soon have a new classification of antidepressant drugs available. These may be classified as “NMDA receptor modulators” or something along those lines."
"It is good to see companies like Naurex branching out into an entirely new direction (away from the highly outdated “serotonin hypothesis”) for the treatment of depression."
And there's more here:
5 New NMDA Receptor (Glutamate) Modulators For Depression
"Recently biotech firms have taken interest in the fact that glutamatergic functioning in the brain can produce an antidepressant effect. This has lead to companies developing drugs that would modulate glutamate functioning via targeting the NMDA receptor."
Hopefully these SSRI replacements do not become a controlled substance due to its relation to Ketamine! Fingers crossed...
Edited by eon, 01 June 2015 - 12:09 AM.