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Modafinil or Armodafinil for Depression: Thoughts?

depression modafinil armodafinil anxiety

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#1 StarLightStarBright

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Posted 06 June 2015 - 06:32 PM


Armodafinil or modafinil?

 

Please post if you have used either or both (preferably) before. Speculations are useful but are largely unhelpful.  ;) 

 

I have used both from HAB Pharmaceutical...and I am not sure so I would like to hear from everyone at LongeCity. I have ordered a new shipment from Sun Pharma and will try it. I have dealt with depression and anxiety on and off for years. However, depression is the most prominent at the moment: I just feel unmotivated...and it sucks because I am a typically high functioning individual  :dry:

 

Therefore, what is everyone's experience with modafinil and armodafinil? I would really appreciate thoughts from individuals who have experienced depression.

 

 

 



#2 drg

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Posted 07 June 2015 - 03:50 AM

Modifinil did not help me for depression and worsened my insomnia hence just fucking everything up even more. It made me less emotional (possibly more ahdenoiac) More focused but not really affecting mood. Not a drug for me, so IDK if my opinions of it on depression matter unless you find it negative in its overall side effect profile.



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#3 karva

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Posted 07 June 2015 - 11:21 PM

I have tried modalert (modafinil), and it is amazing as an anti dressant. I'm desperate to get hold of some. You need to try modafinil, it might wake you up and give you your life back!
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#4 titanxvx

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Posted 08 June 2015 - 08:01 AM

I have found both types have a mild anti-depressant effect. Take first thing in the morning and stick to a firm dosage regimen. For me that's100mg. Don't redose later in the day to avoid problems with sleep.

I used to get them prescribed but insurance won't cover them for "depression" now. I just get them from India and I can't tell the difference.

 


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#5 karva

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Posted 08 June 2015 - 08:33 AM

"Mild antidepressant"? I guess everyone's different, I went from suicidal to skipping with joy within 30 minutes, it made me pick up my guitar again and put a a smilemon my face again. I have a friend giving me some tommorow but in the meantime I'm awaiting an order from a an Asian company ( they seem legit and great prices, I just hope I don't get scammed.
Anyway I tried to get them prescribed by my gp (I'm in the UK) and he treated me like I was fishing for drugs. Apparently ngoing for a walk and getting a job treats the trauma of rape and witnessing a slow painfully death. Patunirising fuck, I used to cycle 20 miles a day, running etc.. And worked 95℅ of my adult life. I'd walk to China and back for my old mental health back if it was that simple.
Try modafinal first, I'm so pleased that i found it, its a life changing medicine for me. Good luck.
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#6 tintinet

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Posted 11 June 2015 - 12:08 AM

Quality sources? Thanks!

#7 AlexCanada

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Posted 12 June 2015 - 12:29 AM

Modafinil can absolutely work wonders for motivation.  Unfortunately I got a severe rash reaction last time. Maybe I can try it again down the road :o

 

ceretropic sells Hydrafinil which appears to be a potential successor :O  Wonder if anyone here has tried it? Less duration of action thus less likely to cause insomnia. 


Edited by AlexCanada, 12 June 2015 - 12:30 AM.


#8 Duchykins

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Posted 13 June 2015 - 04:20 PM

Tried adrafinil (from Powder City),  generally liked it, ordered more.  I don't use it regularly but there is a definite increase in motivation.   Sometimes after a few hours it decreases my anxiety tolerance.  



#9 tintinet

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Posted 13 June 2015 - 04:31 PM

Tried adrafinil (from Powder City), generally liked it, ordered more. I don't use it regularly but there is a definite increase in motivation. Sometimes after a few hours it decreases my anxiety tolerance.


Thanks! Just ordered some. Will follow up.

#10 AlexCanada

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Posted 14 June 2015 - 12:27 PM

Amphetamines are generally not good long term due to downregulation.  Do you guys know if modafinil behaves in the same way? I would like to be able to take adrafinil 4-5 days a week possibly but have my concerns.  If someone is deaing with adrenal burn out but really needs a push would adra/modafinil be acceptable?



#11 pdxer

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Posted 16 June 2015 - 01:16 AM

I have gone through several bottles of Adrafinil. My doses ranged from 300 to 900 mg, over 100 days of dosing. 26 yrs of depression, insomnia and low energy. I've been doing ok the last 4 years but always tired still. Adrafinil has been the most useful substance I've encountered. It takes away the fatigue. It also makes it easier to focus and not get stuck in obsessive loops or have intrusive thoughts. Be careful if you have anxiety. 900 mg with coffee could make me feel a bit edgy.

#12 titanxvx

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Posted 16 June 2015 - 08:17 AM

I have gone through several bottles of Adrafinil. My doses ranged from 300 to 900 mg, over 100 days of dosing. 26 yrs of depression, insomnia and low energy. I've been doing ok the last 4 years but always tired still. Adrafinil has been the most useful substance I've encountered. It takes away the fatigue. It also makes it easier to focus and not get stuck in obsessive loops or have intrusive thoughts. Be careful if you have anxiety. 900 mg with coffee could make me feel a bit edgy.

 

Have you ever tried modafinil or armodafinil for your depression? I tried adrafinil years ago with no success but did react better to modafinil and armodafinil. I'm just curious, have you been diagnosed with narcolepsy?
 



#13 pdxer

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Posted 16 June 2015 - 08:34 AM

I haven't been diagnosed with narcolepsy but it would probably fit. My sleep disturbances began in middle school and I've been struggling to stay awake since. I always assumed I was fatigued because I was depressed, but it could be the other way around. I tried to get a modafinil rx from my doctor and she seemed very cautious and judgmental... as if I was an addict. I even cited concern about driving. I'm not happy with the small risk involved in getting modafinil through other channels.

#14 OneScrewLoose

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Posted 21 June 2015 - 11:02 AM

I would go for modafinil, which is 50% armodafinil (it's a racemic mixture). Armodafinil seems to be more potent in it's wakefulness augmentation, which past a certain point may not help your depression, and might give you a feel of overstimulation. Stick with modafinil if depression is what you're targeting.



#15 tintinet

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Posted 21 June 2015 - 08:36 PM

Just tried 150 mg of adrafinil this AM for the first time. Didn't notice any effects, but my mood is OK. Will try higher doses and consider trying modafinil.

#16 karva

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Posted 21 June 2015 - 09:06 PM

I took 1200mg in one go and felt nothing (one dose is meant to be 150mg). I took half a modafinal and got loads of shit done that I have been putting off, even cleaning is fun on modafinal.

#17 tintinet

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Posted 23 June 2015 - 12:27 AM

300 mg adrafinil this AM just before heading off for work. Seemed to have a mild positive effect on my energy, focus, drive. Cruised on through 6 hours before a significant break. Seemed to mildly depress appetite. Could just be placebo I suppose. More to follow hopefully!

#18 tintinet

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Posted 24 June 2015 - 08:32 PM

300 mg again before work. Seems to help focus, mood, depresses appetite. Some sleep difficulty, but awoke in a good mood regardless.

#19 OneScrewLoose

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Posted 01 July 2015 - 04:16 AM

Adrafinil can cause liver problems with consistent use. It's a prodrug to modafinil, which means it gets converted to modafinil. Perhaps you can get into the modafinil patient assistance program?



#20 tintinet

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Posted 01 July 2015 - 11:28 AM

I have a sample pack including modafinil and armodafinil en route.

#21 OneScrewLoose

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Posted 01 July 2015 - 08:53 PM

Modafinil, being the racemic mixture is slightly different. The S-Modafinil component only has a half-life of about only 4-5 hours, while R-Modafinil (armodafinil) has a half-life of about 14 hours. So with regular modafinil, it will be stronger for the first 4-5 hours until the S-Modafinil is cleared out, and then you are left with the R-Modafinil for the rest of the 14 hours. This can be a good thing if you don't want to be stimmed for so long. Also, armodafinil has more incidences of side effects. Search pubmed for some of the differences. Be sure to give both a fair trial of a week at the last dose you settle on for each. The plasma concentration and CMax is highest after 1 week.


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#22 tintinet

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Posted 05 July 2015 - 10:52 PM

Now have modafinil & armodafinil samples. First dose amounts?

#23 karva

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Posted 05 July 2015 - 11:11 PM

Half a pill (100mg) is enough for me of monodafil
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#24 JoSho

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Posted 06 July 2015 - 04:15 AM

   I have extra wakalert .   ordered online a year ago,  but stopped taking it a few months ago.   no use on letting it go to waste. 

 

pm  me  if interested 

">http://2vaytxu.jpg

must be in US

 

 



#25 tintinet

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Posted 06 July 2015 - 07:41 AM

Why did you stop?

#26 drg

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Posted 06 July 2015 - 01:04 PM

I haven't been diagnosed with narcolepsy but it would probably fit. My sleep disturbances began in middle school and I've been struggling to stay awake since. I always assumed I was fatigued because I was depressed, but it could be the other way around. I tried to get a modafinil rx from my doctor and she seemed very cautious and judgmental... as if I was an addict. I even cited concern about driving. I'm not happy with the small risk involved in getting modafinil through other channels.

The dx is fairly obvious for narcolepsy; if you fall asleep without control throughout the day you might have it. If you have the other symptoms without that symptom it is more likely just a regular sleep problem or something else. 

There are also like "microsleeps" (I think they are called) which you might not notice but other people can tell you if you have them.



#27 Duchykins

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Posted 06 July 2015 - 04:20 PM

I haven't been diagnosed with narcolepsy but it would probably fit. My sleep disturbances began in middle school and I've been struggling to stay awake since. I always assumed I was fatigued because I was depressed, but it could be the other way around. I tried to get a modafinil rx from my doctor and she seemed very cautious and judgmental... as if I was an addict. I even cited concern about driving. I'm not happy with the small risk involved in getting modafinil through other channels.

 

 

That's because you don't have narcolepsy, she knows it, and it is clear to her that you are trying to convince her that you do have narcolepsy or something else that would warrant this prescription.  This is how addicts try to get specific drugs from their doctors.  They call it drug-seeking behavior.  

 

I'm not saying you are an addict but that is the first thing a doctor will see because people try to bullshit and manipulate them all the time.  They are additionally wary of it because there are real legal consequences for the doctor personally if anyone gets the impression they prescribe lots of narcotics, sedatives or stimulants to patients who don't need them.

 

If you keep up your nonsense she will leave a note about it in your medical records for other doctors to read, if she hasn't done it already, so I suggest you calm down.  The diagnostic codes used to indicate drug-seeking behavior and feigning illness are 305.90, V65.2.  You do not want these in your records for future doctors to read.  Actually I suspect many people in LongeCity have at least the V65.2, going by how often I see this kind of post around here.

 

I have some personal experience with this both as having worked in the medical field in the past and as a migraineur who occasionally stumbled across a doctor in the ER who erroneously thought that narcotic painkillers was the way to treat migraines (narcotics are the worst thing to prescribe for migraines, but they didn't know that, they initially assumed I was just trying to get a big oxycodone prescription when I was actually looking for a triptan shot).  This is just the way things are.  


Edited by Duchykins, 06 July 2015 - 04:26 PM.


#28 pdxer

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Posted 06 July 2015 - 06:28 PM

Thanks for the explanation with codes. From her reaction I'm sure she did put a note in my file.

It's disappointing because I want her to tell me what her solution to my problem of falling asleep behind the wheel is. Instead of seriously considering the fact that I am potentially occasionally putting myself and others in danger, I get this robotic addict response.

Unfortunately MDs no longer have unique access to information. I had a fistula years ago, went to a GP and with great embarrassment told him that I had symptoms almost certainly consistent with that. The jackass could barely contain his laughter and said "So you think you have a fistula?" As if I was a masochistic hypochondriac with a weird sexual fetish. Perhaps he was diagnosing me with "ass cutting open seeking behavior. " After examining me he panicked given how serious it was and started a super inept emergency procedure to numb the area, pierce it and drain it. He was so freaked out he was asking the nurse what to do. I could have talked my wife through doing a better job than that loser did.

It's not clear to me that the GPs with whom I've interacted even have IQs north of 140. They far surpass me in ego, but not IQ. I feel like I'm treating them like children and either trying to get info out of them to rule in or out a diagnosis, or guiding them toward what the diagnosis is while helping them feel like it was their idea and I'm not capable of studying.

I've had good experiences with specialists. I'm still looking for a GP who I can just be real with.

#29 drg

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Posted 07 July 2015 - 01:18 AM

women are naturally more risk averse. you might have better luck getting off label prescriptions from a male doctor



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#30 pdxer

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Posted 07 July 2015 - 03:30 AM

Wow, I'd recommend that anyone who follows biology or med research request a copy of their medical record and check for the V65.2 code.

I've had a tremor for years. It was getting worse so I finally went in to have it checked out. I said made the mistake of telling the nurse and GP that I was concerned I had Parkinson's since my Grandfather did and was hoping it could be ruled out. I've followed PD research the 90s probably knew too much. The appt ended with the doctor acting out late stage PD motor behavior even though I told her I was very close to my Grandfather from his earliest stages until end of life.

The neurologist she referred me to diagnosed me with essential tremor and I was relieved not to be diagnosed with PD. I thought the GP was just incapable of listening, but her viewing me as V65.2 would also fit.

I'm requesting my medical record.





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