15 replies to this topic

[ViniMD]

Hey everyone.. I suffer from depression and anxiety since I was 15 yrs old (Im 20 now) but now I have something way worse than my previous symptoms... Im suffering from daily panic attacks (not full blown, just VERY anxious) that was triggered by drug abuse (LSD, weed, amphetamines and coke).

I had my first panic attack (heart rate at 120bpm proved by electrocardiogram, my body members went numb etc, I was still conscious btw) when I mixed LSD and cocaine, but after a few hours it went away and next day I was feeling fine.

I was a daily cannabis smoker and never had any issues with it, but 2 weeks after my first panic attack, I smoked some wax/bho (80% THC) and had the worst panic attack ever, I couldnt understand what my friend was saying to me, I was totally despersonalizated, my heart went up to 160bpm(electrocardiogram) and I had sharp chest pain, I went to the ER and they gave an diazepam injection, after 3 or 4 hours I went back to normal and my heart rate reduced, but this time I didnt have much luck...

next day I woke up with the same feeling of despersonalization, I was VERY anxious and VERY depressed, now it has been like that since that day and that happened 2 months ago, its strange because if I smoke cannabis, take ketamine or any stimulant it gives me full blown panic attack but I if I take MDMA I feel anxiety free while on it, why is that? 

 

Im going to see a psychiatrist next week and Im not sure if I should accept SSRI as a treatment for it, did anyone here had success with SSRI for panic attacks? What kind of treatment would be best?

 

Are panic attacks induced by drug abuse not different from panic attacks induced by stress or anxiety? I believe my symptoms are due to some imbalance of my neurotransmitters  due to the fact that it was triggered by mixing LSD with cocaine (first) and smoking high THC cannabis oil (second) this probably caused an imbalance of receptors so that means low serotonin is probably not the only cause of it, then should it be treated differently?

 

Will SSRI be effective for my condition? 

Maybe an supplement/herbs stack to put some balance on my receptors? Did anyone here suffered from the same thing? 

 

Sorry for the many questions but I really need help at this moment, Cheers guys!

Edited by ViniMD, 21 June 2015 - 04:49 AM.

[Mango]

If you go too far with drugs, you will die.

 

Coke is vasoconstrictor which means you can easily get a heart attack or brain hemorrhage, both of which are fatal. Graveyards are filled with "smart guys" who micro dosed, fooled around and played with drugs. Most of them asphyxiated on their own vomit. LSD is also proven to induce schizophrenia in succeptible brains which means you won't die but hallucinate nightmares for the rest of your life during which you will be hospitalized and submitted to electroconvulsive therapy.

 

Ask your doctor for Prazepam. It is a relatively old benzo from the 60's which doesn't make you tired or confused, but helps to prevent anxiety/panic attacks. Virtually no side effects and very hard to become physically addicted to it.

 

10 mg in the morning, 5 in the afternoon and 10 more in the evening. That's all you need till you calm down.

 

Also, find a girlfriend and indulge yourself as much as you can. If you are unable to, pay a visit to professional. Go to nature as much as you can.

 

Forget about "stacks", SSRI and the rest of b...it. Prazepam and sex.

 

Good luck!

 

Edited by Mango, 21 June 2015 - 08:37 AM.

[OneScrewLoose]

First of all, prazepam is a horrible first choice, along with any benzo, for anxiety when nothing else has been tried.  I don't think any doc would even give you prazepam as it's quite addictive and seems to be used for few things these days even if they did give you a benzo (you would likely get klonopin or ativan for occasional use along with something else). SSRIs are a fine first choice, and I recommend the newer ones, Viibryd of Brintellix in that regard.

What's likely happened is that the drug use had triggered some base anxiety that is being augmented by your fear of anxiety itself. Medication could help a lot with this aspect.

Go to the doctor, have an honest discussion, and give a real shot to what he or she gives you. SSRIs/SNRIs take about 5 weeks to take full effect. Remember, if you go on one, there's nothing that's permanent about if; if you don't like it, there are many other options.

[ViniMD]

Thanks for ur answer OneScrewLoose, I had a hope that there would be a more "natural way" to go but after thinking and rethinking and researching ill give SSRIs a try, ill take it for at least 2 months, if one doesnt work welll im just going to switch to another one.. I heard of someone with the same problem as me that had success with Paxil, so im going to ask my doc to start with that one... The SSRIs u mentioned are still not availabe in my country ( Brazil ).

 

Im still open to more ideas btw, and if one wants to discuss what the factors that are causing this attacks could be please drop a line here and lets see if we can come to an conclusion... Thanks everyone

 

EDIT: I was still looking around a bit and... that the kind of thing that im worried about: 

 

http://www.longecity...agerisk-thread/

 

not only that, but I was reading a lot of reports in portuguese of people who tried SSRIs and made their condition worse, some cases  it even takes 6 months to recovery from the SSRIs long term damage... I really dont know what to do..

Edited by ViniMD, 21 June 2015 - 02:03 PM.

[nowayout]

First, stop treating your anxiety with MDMA.

[Mango]

Thanks for ur answer OneScrewLoose, I had a hope that there would be a more "natural way" to go but after thinking and rethinking and researching ill give SSRIs a try, ill take it for at least 2 months, if one doesnt work welll im just going to switch to another one.. I heard of someone with the same problem as me that had success with Paxil, so im going to ask my doc to start with that one... The SSRIs u mentioned are still not availabe in my country ( Brazil ).

 

Im still open to more ideas btw, and if one wants to discuss what the factors that are causing this attacks could be please drop a line here and lets see if we can come to an conclusion... Thanks everyone

 

EDIT: I was still looking around a bit and... that the kind of thing that im worried about: 

 

http://www.longecity...agerisk-thread/

 

not only that, but I was reading a lot of reports in portuguese of people who tried SSRIs and made their condition worse, some cases  it even takes 6 months to recovery from the SSRIs long term damage... I really dont know what to do..

 

The guy who advised you to go ahead and use SSRI forgot about some serious side-effects that these drugs have, whether it's paroxetine or not, doesn't really matter. You will become fat, impotent, completely deprived of any inhibitions whatsoever (meaning your moral values will become virtually non existent), you will become completely desensitized to any emotional stimuli (no laugh, no cry), you won't experience human touch as you have before, etc. In a nut shell, you will become a walking zombie. Also, it takes 2-3 weeks for them to start working. I won't even start with nightmares, suicidal tendencies, etc.

 

Prazepam will just remove the fear of the "fear itself" and won't affect you in any way other than preventing anxiety attacks. It is also a good transit from your current state to the state of taking no medications at all, which I presume is your main goal, which means it will weaken any withdrawal symptoms that you might experience after you discard coke, MDMA, weed, LSD and whatever else you are used to take. Remember, there are not only physical addictions but psychological as well.

 

Here is a clinical trial from ncbi:

 

A single-blind, parallel group, multi-centre study was carried out in 2009 patients with an anxiety state to compare the efficacy, tolerance and withdrawal effects of prazepam and diazepam in therapeutically equivalent doses. Patients were allocated at random to receive 30 mg prazepam or 15 mg diazepam per day, either in divided dosage (3 times) during the day or as a single large dose at night. After a 2-week treatment period, drug therapy was withdrawn gradually. Patients were followed-up at weekly intervals over the 4-week study period. Hamilton Anxiety Rating Scale scores and physicians' global assessment of response at each visit indicated that whilst both drugs and dosage regimens were effective patients treated with diazepam responded rather less well and had a greater return of anxiety symptoms after therapy was stopped compared to those on prazepam. Moreover, the prazepam-treated patients, especially those on the divided daytime dosage regimen, had fewer and milder side-effects in the early treatment period. Dizziness was least apparent in the prazepam single night time dosage group and it is suggested that this may be an important practical consideration in the treatment of anxiety in the elderly.

 

Good luck!

 

Edited by Mango, 21 June 2015 - 04:40 PM.

[ViniMD]

I never mentioned I was treating myself with MDMA, after my panic symptoms started I just tried it once to see if it would give me an attack, but I was surprised that it had the totally opposite effect, maybe by understanding why MDMA makes me anxiety free thru its mecanisms of action in the brain I can find the right "stack" or meds or whatever is going to work for my condition! Someone who have a point of view on that say something here please! Thanks

Edited by ViniMD, 21 June 2015 - 05:06 PM.

[ViniMD]

Thanks mango, but I want to stay far away from any type of benzos, I have a friend who went to deep into this sh*t and now never gets out of his room cuz hes totally anxious about socializing, he doesnt feel relaxed anywhere apart from hiding inside his room under his bed :(

 

I started a stack yesterday that include:

zinc

vitamin b6

rhodiola nature's plus

taurine

tryptophan

LAvender and black peppercorn essential oil (instant relief). 

 

Today (second day) im feeling so relaxed, feels like anxiety is gone, just a lil too much stimulated that I believe its from rhodiola... may be a placebo effect lets see, ill update it here tomorrow.

[ViniMD]

anyone?

[OneScrewLoose]

 

Thanks for ur answer OneScrewLoose, I had a hope that there would be a more "natural way" to go but after thinking and rethinking and researching ill give SSRIs a try, ill take it for at least 2 months, if one doesnt work welll im just going to switch to another one.. I heard of someone with the same problem as me that had success with Paxil, so im going to ask my doc to start with that one... The SSRIs u mentioned are still not availabe in my country ( Brazil ).

 

Im still open to more ideas btw, and if one wants to discuss what the factors that are causing this attacks could be please drop a line here and lets see if we can come to an conclusion... Thanks everyone

 

EDIT: I was still looking around a bit and... that the kind of thing that im worried about: 

 

http://www.longecity...agerisk-thread/

 

not only that, but I was reading a lot of reports in portuguese of people who tried SSRIs and made their condition worse, some cases  it even takes 6 months to recovery from the SSRIs long term damage... I really dont know what to do..

 

The guy who advised you to go ahead and use SSRI forgot about some serious side-effects that these drugs have, whether it's paroxetine or not, doesn't really matter. You will become fat, impotent, completely deprived of any inhibitions[citation needed] whatsoever (meaning your moral values will become virtually non existent), you will become completely desensitized to any emotional stimuli[citation needed](no laugh, no cry), you won't experience human touch as you have before[citation needed], etc. In a nut shell, you will become a walking zombie. Also, it takes 2-3 weeks for them to start working. I won't even start with nightmares, suicidal tendencies, etc.

 

Prazepam will just remove the fear of the "fear itself" and won't affect you in any way other than preventing anxiety attacks. It is also a good transit from your current state to the state of taking no medications at all, which I presume is your main goal, which means it will weaken any withdrawal symptoms that you might experience after you discard coke, MDMA, weed, LSD and whatever else you are used to take. Remember, there are not only physical addictions but psychological as well.

 

Here is a clinical trial from ncbi:

 

A single-blind, parallel group, multi-centre study was carried out in 2009 patients with an anxiety state to compare the efficacy, tolerance and withdrawal effects of prazepam and diazepam in therapeutically equivalent doses. Patients were allocated at random to receive 30 mg prazepam or 15 mg diazepam per day, either in divided dosage (3 times) during the day or as a single large dose at night. After a 2-week treatment period, drug therapy was withdrawn gradually. Patients were followed-up at weekly intervals over the 4-week study period. Hamilton Anxiety Rating Scale scores and physicians' global assessment of response at each visit indicated that whilst both drugs and dosage regimens were effective patients treated with diazepam responded rather less well and had a greater return of anxiety symptoms after therapy was stopped compared to those on prazepam. Moreover, the prazepam-treated patients, especially those on the divided daytime dosage regimen, had fewer and milder side-effects in the early treatment period. Dizziness was least apparent in the prazepam single night time dosage group and it is suggested that this may be an important practical consideration in the treatment of anxiety in the elderly.

 

Good luck!

 

The [citation needed] is me asking how this applies to every single person who takes an SSRI, as these side-effects can indeed happen in some. If there were no variable differences between people with drugs like SSRIs, we would only need one antidepressant ever.

This is that clinical trial: http://www.ncbi.nlm..../pubmed/6353434. It's from the 80s from a journal that not only is no longer publishing, but has a impact factor of 0, which means no one has even cited it. The likelihood that 2 weeks of benzos use will cure his anxiety is almost non-existent. That is not how these drugs work. With long-term use, it can take months, or even a year, to fully quit. If the SSRI doesn't work out, in can be stopped in 2-3 weeks with tapering.

@ViniMD. If that stack is helping you, 5-HTP + EGCG may be quite effective for you. The thing with Rhodiola and most adaptogens, however, is that tolerance builds quickly with daily use. Try to use as needed. What form of Zinc do you use? How much Taurine?

Send you a PM. Glad you're feeling better!

[ViniMD]

 

 

Thanks for ur answer OneScrewLoose, I had a hope that there would be a more "natural way" to go but after thinking and rethinking and researching ill give SSRIs a try, ill take it for at least 2 months, if one doesnt work welll im just going to switch to another one.. I heard of someone with the same problem as me that had success with Paxil, so im going to ask my doc to start with that one... The SSRIs u mentioned are still not availabe in my country ( Brazil ).

 

Im still open to more ideas btw, and if one wants to discuss what the factors that are causing this attacks could be please drop a line here and lets see if we can come to an conclusion... Thanks everyone

 

EDIT: I was still looking around a bit and... that the kind of thing that im worried about: 

 

http://www.longecity...agerisk-thread/

 

not only that, but I was reading a lot of reports in portuguese of people who tried SSRIs and made their condition worse, some cases  it even takes 6 months to recovery from the SSRIs long term damage... I really dont know what to do..

 

The guy who advised you to go ahead and use SSRI forgot about some serious side-effects that these drugs have, whether it's paroxetine or not, doesn't really matter. You will become fat, impotent, completely deprived of any inhibitions[citation needed] whatsoever (meaning your moral values will become virtually non existent), you will become completely desensitized to any emotional stimuli[citation needed](no laugh, no cry), you won't experience human touch as you have before[citation needed], etc. In a nut shell, you will become a walking zombie. Also, it takes 2-3 weeks for them to start working. I won't even start with nightmares, suicidal tendencies, etc.

 

Prazepam will just remove the fear of the "fear itself" and won't affect you in any way other than preventing anxiety attacks. It is also a good transit from your current state to the state of taking no medications at all, which I presume is your main goal, which means it will weaken any withdrawal symptoms that you might experience after you discard coke, MDMA, weed, LSD and whatever else you are used to take. Remember, there are not only physical addictions but psychological as well.

 

Here is a clinical trial from ncbi:

 

A single-blind, parallel group, multi-centre study was carried out in 2009 patients with an anxiety state to compare the efficacy, tolerance and withdrawal effects of prazepam and diazepam in therapeutically equivalent doses. Patients were allocated at random to receive 30 mg prazepam or 15 mg diazepam per day, either in divided dosage (3 times) during the day or as a single large dose at night. After a 2-week treatment period, drug therapy was withdrawn gradually. Patients were followed-up at weekly intervals over the 4-week study period. Hamilton Anxiety Rating Scale scores and physicians' global assessment of response at each visit indicated that whilst both drugs and dosage regimens were effective patients treated with diazepam responded rather less well and had a greater return of anxiety symptoms after therapy was stopped compared to those on prazepam. Moreover, the prazepam-treated patients, especially those on the divided daytime dosage regimen, had fewer and milder side-effects in the early treatment period. Dizziness was least apparent in the prazepam single night time dosage group and it is suggested that this may be an important practical consideration in the treatment of anxiety in the elderly.

 

Good luck!

 

The [citation needed] is me asking how this applies to every single person who takes an SSRI, as these side-effects can indeed happen in some. If there were no variable differences between people with drugs like SSRIs, we would only need one antidepressant ever.

This is that clinical trial: http://www.ncbi.nlm..../pubmed/6353434. It's from the 80s from a journal that not only is no longer publishing, but has a impact factor of 0, which means no one has even cited it. The likelihood that 2 weeks of benzos use will cure his anxiety is almost non-existent. That is not how these drugs work. With long-term use, it can take months, or even a year, to fully quit. If the SSRI doesn't work out, in can be stopped in 2-3 weeks with tapering.

@ViniMD. If that stack is helping you, 5-HTP + EGCG may be quite effective for you. The thing with Rhodiola and most adaptogens, however, is that tolerance builds quickly with daily use. Try to use as needed. What form of Zinc do you use? How much Taurine?

Send you a PM. Glad you're feeling better!

 

 

I'm surprised how good im doing on this stack, it vanished my depression, negative thoughts and most of my anxiety (no heart racing, chest pain or heart murmur and spams).

 

Thanks for the advice, I just introduced 5-HTP and l-theanine in to my stack today, I took 50mg of 5-HTP sublingually in the morning along with rhodiola (100mg), magnesium chloride (300 mg, I take this dose 3x a day) and zinc chelated (15mg). At the evening I dosed 100mg of l-theanine, 3mg of vitamin b6 (pyridoxal) and another 15mg of zinc chelated.

 

I was thinking of stop taking taurine due to the GABA down-regulation it can cause in long term, or, should I keep taking it? My taurine dose is 1g before bed. Ive some gotu kola here should I switch from taurine to gotu ? 

 

You said 5htp would be effective but is tryptophan not safer than 5-HTP? Or the research saying that 5htp causes heart valve damage is not relevant?

 

I had a look at the ScienceGuy topic about anxiety, and Im wondering if I should introduce the following into my stack:

 

L-Glutamine

Vitamin B12 (methylcolab)

Bacopa

Inositol

Vitamin b6 (p5p)

Ashwagandha (I know theres taurine in my stack for GABA, but is it not a better option?)

Ehh, ECGC is too expensive for me as they dont sell it here in Brazil, could I just take a green tea supplement? It comes in capsules (500mg).

 

Thanks again OneScrewLoose, by the way I didnt receive ur PM.

 

Im still kind afraid of SSRIs as Ive seen lots of reports of people that suffered from withdrawals even slowly tapering their use, I dont want to depend on a med for the rest of my life, Ill try this supplements first.

Edited by ViniMD, 22 June 2015 - 04:42 AM.

[ViniMD]

ehh, the vitamin b6 is actually pyridoxine... is it worth taking it? I heard it can be neurotoxic, whats the safe dosage for it? Thanks

[Flex]

ehh, the vitamin b6 is actually pyridoxine... is it worth taking it? I heard it can be neurotoxic, whats the safe dosage for it? Thanks

seems that 200mg would be a high dose

http://www.mayoclini...ty/hrb-20058788

 

I'm surprised how good im doing on this stack, it vanished my depression, negative thoughts and most of my anxiety (no heart racing, chest pain or heart murmur and spams).

 

 

- You could look for green tea extracts, like this one:

http://en.olimp-labs.../GREEN-TEA.html

 

It contains in fact a standarized EGCG content and is here in europe very cheap (~5 Euro).

Be careful ! even 2 pills do potently thinn the blood ( at least to me)

 

- Switch from taurine to Gotu. Dont know why Youre taking Taurine but You would do better with Gotu in terms of anxiety.

This and Ashwa are actually weak to medicore in anxiety relief (Bacopa is weaker). Dont know, if You have Gotu, then Ashwa would/could be needless

( buy allways standarized extracts)

 

See, Examine:

http://examine.com/s...ia officinalis/

 

Try Kava Kava or Magnolia (calcium channel blocker and Gabaergic) if Youre looking for stronger natural Gabaergics.

The combo with Lemonbalm ( a Gaba degradation inhibitor) should blow You away but try to not overdo especially with alcohol.

 

Who knows, You might get a respiratory depression or something like that

https://en.wikipedia...Hypoventilation

 

- Btw Lavender is calcium channel blocker. Just if Youre curious

 

- 5-ht (tryptophan) is safer than 5-htp because the first one needs to be metabolized and underlies the body owns limitations = "afaik" not possible to overdose.

5-htp can be overdosed, up a point where You have to go to the hospital ! ( serotonine syndrome)

 

No need to throw it away, just be careful. 200mg were for me a good dose but I would start at 50mg.

Again dont get the Idea that Halucinogenics, MDMA (or anything that affects Serotonine) + 5-htp would be a great idea !!

If Youre still keen on it, then start at 10mg (?) since theres no antidote.

I´ve taken LSD + ~75mg 5-htp and could only sleep 2 hours for the next 2 days

Admittely I was manic and fearless but it might be harmful.

 

- Heart valve problems come just after longterm usage. So afaik regulary for Months to Years.

 

- Mango made a good point about the SSRI Antidepressants:

They "can" cause perresistent sexual dysfunctions ( google PSSD) and they last for some 15 years !

Dont want to scare You but just dont throw that stuff in just like this. Inform Yourself before.

 

I would presonally suggest Trycyclics like Nortryptiline or Clomipramine

 

Benzo´s like Valium & etc. can cause also some nasty side-effects but afaik only after several months or so (?)  there are several threads about it.

 

- About the cause:

I cant of course tell it defietly. I can only talk about my own experiences and some research papers that I´ve read and might draw sometimes just wild conclusions.

 

I´ve taken a higher dose of Escitalopram (IIRC 15mg) and got very anxious and a bit psychotic for 1 hour.

I got similair experiences actually allways when smoking too much Weed and when once mixed Weed + MDAI (a boring non-emphatogen 5-ht releaser)

So I would initially tip onto too much Serotonine.. actually but You did well with 5-ht..

---------------------------------------------

I´ve looked into LSD and it might increase the expression of Dopamine D2 and 5-ht2a Receptors, which could be responsible for some lasting effects:

 

Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice.

It has been previously demonstrated that hallucinogenic 5-HT2A receptor agonists cause induction of c-fos, egr-1, and egr-2 in mouse cortical neurons (Gonzalez-Maeso et al. 2003, 2007). Expression of c-fos is induced by all hallucinogenic and nonhallucinogenic drugs studied that activate the 5-HT2A receptor.........

 

Expression of c-fos, egr-1, and egr-2 was undistinguishable in somatorensory cortex of mice chronically treated with clozapine followed by acute vehicle as compared to mice chronically treated with vehicle followed by acute vehicle (Table 1). The induction of c-fos, egr-1, and egr-2 by LSD was not affected by short-term treatment with clozapine....

http://www.ncbi.nlm....les/PMC3552490/

 

AN ANIMAL MODEL OF SCHIZOPHRENIA BASED ON CHRONIC LSD ADMINISTRATION: OLD IDEA, NEW RESULTS

http://www.ncbi.nlm....les/PMC3110609/

---------------------------------------------

 

Does this explain Your Symptoms ? Yes/No: Then why are You responding to Tryptohan ? or is Tryptophan too regulated by the body to exert any effects ? or didnt LSD affected You or just in a completly other way ?

 

You see how difficult this is. So better You print an abstract/study and show it to Your Doc if hes clueless or to bring in

Your own assumptions (And change the Doc if Youre seeing no progress or any greater differences) because they treat sometimes symptomatically which might not allways work.

(The same could be done for PSSD considerations & etc.)

 

I would look rather into this Studies when theres no other way or the chances are low to find any help like in my case.

 

- Regarding Cocaine:

There are many peristent changes and of course some damages( micro strokes after every usage).

Better dont touch it anymore. I´ve made a whole thread in the attempt to reverse "just a few" alterations:

 

Cocaine News + reversal thread

http://www.longecity...eversal-thread/

Edited by Flex, 23 June 2015 - 11:19 PM.

[ViniMD]

first, thanks for ur response Flex..  Im not really sure about 5-HTP being effective as I would take it and go straight to bed, I took it once in the morning but dont really think it made any difference cuz I took rhodiola and theanine with it.

 

What is really helping with anxiety is rhodiola, but unfortunately as every adaptogen its losing its magic. Theanine is the only thing thats working now by lifiting up my depression and it also  helps a little with anxiety, but untill when? Magnesium and zinc helps a little as well...

 

I will start Gotu Kola tonight and im going to order some magnolia. I shouldnt consider ashwa then right? 

 

What u saying is that I might have high levels of serotonin, that means I should stay away from any 5ht agonists?

Ill try clozapine, any other 5ht antagonists that could be effective?

 

Im not really an expert in this area sorry if that question doesnt make sense, but... using a 5htp antagonist would not upregulate dopamine? Dopamine = anxiety (?)

 

Im sure the neurotransmitters which play a role on panic attacks induced by drugs(the ones I mentioned) are dopamine and serotonin, any other receptor that could be affected?

 

About mixing LSD with 5htp, I cant do that even if I wanted, it seems like my brain made a connection between LSD and panic attacks, same for weed, if I take 1/4 of a tab I already have a panic attack, if I take one puff of maryjane ill have a panic attack, MDMA is actually the only drug I can take without anxiety symptoms, but its not on my plans as I want to recover as fast as possible.

 

Edited by ViniMD, 24 June 2015 - 12:37 AM.

[ViniMD]

Today for the first time in my life I went to a psychiatrist, as I expected he prescribed the following meds:

Lexapro

Olanzapine

Naltrexone

 

Would any of this meds be good for my case? (apart from lexapro, ill try to avoid any SSRIs)

 

I abused alcohol as well and I forgot to mention. maybe afobazole could help modulate my GABA receptors?

 

I know I ask too many questions haha, but im desperate right now, Thanks again

[Flex]

Ashwa might be actually redudant if You have Gotu Kola and Magnolia.

 

Yes adaptogens get weaker but depending on their mechanism, some effects could stay to some extend.

Pehaps the Rhodiola would behold its effecs.

 

Kava Kava modulates afaik gaba A receptors for several weeks but cant find that paper on a quick search where the weeks/months are stated.

Its also a (reversible) mao-b inhibitor and a relative weak cannabinoid CB1 agonist.

 

A standarized extract of St. Johns wort like Perika could be also nice (if You have the money and able to buy smaller quantities for testing)

It a relative weak to medicore reputake inhibitor of Noradrenaline, Serotonine, Dopamine,Gaba and indirectly Glutamate (via glutamine).

 

Here are some further Gabaergics:

Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin
http://sydney.edu.au...efsPDFs/376.pdf

 

Edit: Muscimol is Halucinogenic on its self but via Gaba agonsim.

If You decide to take it, then better avoid mid & high doses. And use only propperly dried ones otherwise they´re neurotoxic

 

I cant unfortunaetly say whether Serotonine is the cause in You..

Rhodiola inhibits, dosedependly, mao-a, mao-b and Comt to ~90%, ~90% and ~60% reversible

so its actually elevating Serotonine. Could be something different as well, dont know.

 

Ok, "I would" buy a small dose 5-htp and see whether its affecting You.

It might be also the opposite i.e. too low Serotonine.

Or too low dopamine or its just related to a under (PFC) - or overactive(HPA axis) brain region/structure or a certain receptor like beta adrenergic ?

So see what THC, LSD affects( could end in a hughe mountain of informations, just saying) and draw "some" conclusions.

 

This is actually my desperate attempt to my own issues. Better try to avoid experimenting because there are some dangers like adrenergic a2 inhibition (via Mirtazapine) + Glutamate elevating stuff

(afaik sub-chronic THC, NMDA inhibitors, maybe Sarcosine) which might probalby damages You because too much Glutamate..  or cause brain bleeding & etc... I´m talking about Years of recherche...

 

- Olanzapine might give You some side effects like decreased/absent Libido, cognitive impairment, perhaps even anxiety via dopamine d2 blockade & etc.

This lasts, dose dependly, up to 1-2 Years. So if Youre taking just a few, it might last some days to weeks.

 

Dont want to say to: not using it ! Theres still a reason why Your Doc has studied for so long to become one.

though its nothing perfect otherwise every MD would know about PSSD and dont hand it that easily out.

 

It might help, I dont know, You dont know. These are the side effect which are reversible.

Afaik: receptor gets destroyed(1-3 days) then re-build(few weeks) and then re-embedded (~1 year). This is the reason for 1-2 Years.

 

It might be just problematic if Youre going to school or study.

Risperdal made it for me impossible to comprehend Math & etc, had to quit.

Whereas some schizophrenics (btw, I´m not ) can study while on Antipsychotics.

 

I would try one/ a few pill(s) and look

I can only talk for my self but in this case, You would have to carry the consequences...

 

Naltrexone is for the Depersonalisation.

You seem to have a modern Doc.

Edited by Flex, 24 June 2015 - 01:14 AM.