Does L tryptophan causes tolerance and downregulation of serotonin receptors?
It cant be like that right? that would mean eating protein foods would cause tolerance
Posted 25 June 2015 - 04:25 PM
Does L tryptophan causes tolerance and downregulation of serotonin receptors?
It cant be like that right? that would mean eating protein foods would cause tolerance
Posted 25 June 2015 - 05:02 PM
In my opinion, for a healthy person everything balances out. Protein does not oversupply tryptophan to the brain because it provides competition for tryptophan's transport into the brain.
Posted 25 June 2015 - 10:53 PM
Edited by 640ng, 25 June 2015 - 10:53 PM.
Posted 26 June 2015 - 12:29 AM
The first time or two that I took 500mg of L-Trp, I had a pretty big effect from it; I slept well. Subsequent doses had less effect. Part of the regulation of Trp to 5htp is simply the expression level of enzyme, and that might respond to the level of substrate. If there is a high level of substrate, maybe that down-regulates expression. That's a common biological scenario.
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