• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Scientists model the complex relationship between energy expenditure and longevity

longevity energu expenditure ros cellular oxidation

  • Please log in to reply
No replies to this topic

#1 Kalliste

  • Guest
  • 1,147 posts
  • 158

Posted 27 June 2015 - 06:17 PM


Found this on Suppversity today. Sounds interesting

 

 

Scientists model the complex relationship between energy expenditure and longevity

The relationship between energy expenditure and longevity has been a central theme in aging studies. Empirical studies have yielded controversial results, which cannot be reconciled by existing theories. In this paper, we present a simple theoretical model based on first principles of energy conservation and allometric scaling laws. The model takes into considerations the energy tradeoffs between life history traits and the efficiency of the energy utilization, and offers quantitative and qualitative explanations for a set of seemingly contradictory empirical results. We show that oxidative metabolism can affect cellular damage and longevity in different ways in animals with different life histories and under different experimental conditions. Qualitative data and the linearity between energy expenditure, cellular damage, and lifespan assumed in previous studies are not sufficient to understand the complexity of the relationships. Our model provides a theoretical framework for quantitative analyses and predictions. The model is supported by a variety of empirical studies, including studies on the cellular damage profile during ontogeny; the intra- and inter-specific correlations between body mass, metabolic rate, and lifespan; and the effects on lifespan of (1) diet restriction and genetic modification of growth hormone, (2) the cold and exercise stresses, and (3) manipulations of antioxidant.

www.suppversity.com | Hou, Chen, and Kaushalya Amunugama. "On the Complex Relationship between Energy Expenditure and Longevity: Reconciling the Contradictory Empirical Results with a Simple Theoretical Model." Mechanisms of Ageing and Development (2015).

 

 

 

 

11058790_985729848125832_858484042926108







Also tagged with one or more of these keywords: longevity, energu, expenditure, ros, cellular oxidation

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users