Yeah agmatine sulphate is also a very good chemical, memantine seems to have more noticeable effects for better or worse, probably due to it being extremely specific. Agmatine acts on like 3 different mechanisms all together that can reduce tolerance indirectly. So its a for withdrawal/rebound its a great supplement to consider on together with rhodiola and ashwagandha.
Indeed. Its effects are quite unique.
On the subject of reducing tolerances and improving general cognitive function, here is a quote from another forum which provides some interesting and unique perspectives:
"In either case the only detriment to NMDA antagonism is cognitive deficit. It dissociates you just like ketamine in a dose dependent way, limiting spacial coordination and complex thought. The benefits of it are worthwhile though: addiction control, tolerance control, antidepressant..."
I have a set of plants/supplements i use for revitalising/refreshing by neuronal system as well as increasing its cognitive potential. Notably NMDA antagonists, Prolactin Inhibitor (prolactin inhibits the dopamine system) and blue lotus (this resensitizes and balances the dopamine system)
We're actually waiting for approval from the insurance for the additional testing right now... sucks...
BUT I would be so excited to find something that could help not just me but my daughter, who is in a way worse position than I am on the spectrum (she's speech delayed whereas I was an early and prolific reader)
Sorry to hear. I'm from the UK by the way, I've heard many a tale about the American "Health Care" system...
I have a fair bit of exposure to and experience of autism & related "conditions" (eugh hate that word in this context...)
Have you explored all avenues for possible solutions/improvements of autism?
Notably diet (for example, avoidance of oxalic acid/gluten/lectins) as well as the removal of all toxic substances and heavy metals that can play an integral role in autism - for example:
Polyunsaturated fatty acids (omega 6 - they have the effect of signalling the body into a hibernating state thus slowing down metabolism which is not desirable. They also promote inflammation as they are converted to inflammatory substances)
Fluoride/Bromide/Chlorine
Mercury
Aluminium
PTFE (non stck Teflon coating)
BPA (synthetic estrogen mimicking endocrine disruptor found in plastic and lining the inside of the metal on canned goods.
Pesticides (are you familiar with the "dirty dozen" - a list of the non organic food items with the highest risk of containing pesticides)
Vaccines (tend to contain some notoriously toxic substances as well as the vaccine itself which can contribute to an imbalance the immune system response, ie th1 verses th2)
Antibiotics - can decimate ones gut flora population and diversity which, due to their symbiotic nature with our health, can contribute to overall health issues
Gluten (including other grains except white rice) & Dairy
Both the Caesin protein and proteins in gluten can be improperly digestsled into peptides with opioid properties. This can further destabilise a persons neuronal system.
Detoxing from the above is feasible and for the most part, cheap.
Liver support (master detoxification organ. Its function can be improved by the use of bitters which stimulate the vagus nerve, thus digestion - but also the liver)
Sodium thiosulphate (de chlorinates water)
Boron (as borax decahydrate, a natural antifungal, removes fluoride and provides much missing boron element to the body, a lack which is implicated in arthritis)
Lugols iodine solution (removes Fluoride and Mercury)
Source of sulphur in diet (sulphur used by the livers detox system)
Probiotic foods such as cultured (fermented) vegetables and drinks (eg water kefir)
A consideration of the condition of ones digestive tract - notably looking out for signs of leaky gut (which can include immune issues and inflammation)
Things such as electromagnetic radiation have a role to play as well, notably indoor WiFi signals. I am lucky to live on the very top floor which is the furthest room from the WiFi router that is on 24/7 (except when I turn it off whilst I am spending a large amount of time nearby
Related to the above, have you heard of the element called Indium? It appears to be critical in the proper fictioning of the bodies hormonal system, and most humans are significantly deficient/completely lacking in it by age 25. Since taking a drop evert few days, I have definitely felt an overall improvement; notably fluidity in all aspects!
Silica is another important element, i use food grade diatomaceous earth which I sprinkle a tiny amount into my water which sits for at least a day. The water turns the silica rich diatomaceous earth into a highly bioavailable form of silica. Silica is more important than calcium for bone health!
Ah...and lastly, Gelatin (collagen powder) is also very effective at detoxing, as a result of its ideal ratio and content of amino acids (lacking tryptophan, methionine and cysteine, but this is part of its appeal)
I use a brand in a green cylindrical container that is pure collagen hydroslate, which means the proteins have been hydrolysed to their component amino acids which improves absorption significantly!
(The glycine amongst other things, aids liver detoxification)
Edited by sativa, 11 July 2015 - 08:41 AM.