42 replies to this topic

[psychejunkie]

SAM-e boosts Glutathione

[gamesguru]

galantamine, blueberries, broccoli, garlic, exercise. probiotics according to one source. according to another: milk thistle, whey protein, sulfur, NAC, ALA, B6, B9, B12, biotin, C, E, selenium, and oddly enough, beef liver.

[YANNO]

NAC works, i take spectracell bloodtests a couple times a year

 

and u can clearly see the improvement in glutathione after using NAC. I just didnt know that it promotes asthma (if thats true)

[psychejunkie]

NAC works, i take spectracell bloodtests a couple times a year

 

and u can clearly see the improvement in glutathione after using NAC. I just didnt know that it promotes asthma (if thats true)

Actually NAC promotes Hypoxia and increases every Hypoxic-related gene expression!

[TheLovedOne]

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients ... Asthma associated with N-acetylcysteine infusion and …

 

I know those infusions for treating paracetamol are at relatively high dose. But towards the end of my modest usage (1500mg day as 3 500 mg doses) I was getting a lung reaction whenever I took a dose. At first I was convinced it was the pulmonary hypertension thing but I had an ultra-sound which ruled that out. Then I had to have use a cortisone inhaler on and off for several before it eased off.

[natasjlp]

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients ... Asthma associated with N-acetylcysteine infusion and …

 

I know those infusions for treating paracetamol are at relatively high dose. But towards the end of my modest usage (1500mg day as 3 500 mg doses) I was getting a lung reaction whenever I took a dose. At first I was convinced it was the pulmonary hypertension thing but I had an ultra-sound which ruled that out. Then I had to have use a cortisone inhaler on and off for several before it eased off.

 

 

http://emj.bmj.com/c...t/19/6/594.full

 

from first link conclusion: "In conclusion, in most cases the use of N-acetylcysteine to treat paracetamol overdose is both safe and efficacious. Anaphylactoid reactions are common though usually mild. This case however, illustrates that the treatment of brittle asthmatic patients requires particular caution. This would include a careful risk/benefit assessment of treatment, precise N-acetylcysteine dose calculation, possible use of slowed initial drug infusion rates, close observation, and the immediate availability of resuscitation equipment and staff."

[YANNO]

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients ... Asthma associated with N-acetylcysteine infusion and …

 

I know those infusions for treating paracetamol are at relatively high dose. But towards the end of my modest usage (1500mg day as 3 500 mg doses) I was getting a lung reaction whenever I took a dose. At first I was convinced it was the pulmonary hypertension thing but I had an ultra-sound which ruled that out. Then I had to have use a cortisone inhaler on and off for several before it eased off.

 

 

 

dammmm

 

thanks for the info my friend

[natasjlp]

 

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients ... Asthma associated with N-acetylcysteine infusion and …

 

I know those infusions for treating paracetamol are at relatively high dose. But towards the end of my modest usage (1500mg day as 3 500 mg doses) I was getting a lung reaction whenever I took a dose. At first I was convinced it was the pulmonary hypertension thing but I had an ultra-sound which ruled that out. Then I had to have use a cortisone inhaler on and off for several before it eased off.

 

 

 

dammmm

 

thanks for the info my friend

 

 

if you read at the end of the article:

 

""In conclusion, in most cases the use of N-acetylcysteine to treat paracetamol overdose is both safe and efficacious. Anaphylactoid reactions are common though usually mild. This case however, illustrates that the treatment of brittle asthmatic patients requires particular caution. This would include a careful risk/benefit assessment of treatment, precise N-acetylcysteine dose calculation, possible use of slowed initial drug infusion rates, close observation, and the immediate availability of resuscitation equipment and staff.""

[natasjlp]

 

NAC works, i take spectracell bloodtests a couple times a year

 

and u can clearly see the improvement in glutathione after using NAC. I just didnt know that it promotes asthma (if thats true)

Actually NAC promotes Hypoxia and increases every Hypoxic-related gene expression!

 

 

Do you have a reference for this? I have only found positive effects from NAC in published studies, other than anomalies specifically referring to extreme cases of asthma.

 

The Overlooked Compound That Saves Lives

http://www.lifeexten...ysteine/page-01

 

• In one of the original animal studies demonstrating that oxidative stress contributes to development of PAH induced by hypoxia, NAC actually reduced the heart and lung changes that lead to PAH, in part by reducing toxic peroxide molecules.80
• NAC, given before and at the beginning of experimental hypoxia, was effective at preventing PAH, including deadly heart muscle changes, in laboratory rats.82
• NAC protects experimental animals’ lungs from the acute lung injury caused by a variety of mechanisms involving hypoxia, oxidant stress, and inflammation, through its joint antioxidant and anti-inflammatory actions.83,84
• A study of human volunteers revealed that NAC supplements at 1,800 mg/day increased the healthy respiratory response to hypoxia,85 which normally declines strongly with age and may contribute to PAH.86Although this study was cited by the Virginia group as supporting their concern about NAC inducing PAH, no such evidence is presented in the human study, and in fact the authors conclude that NAC treatment “may be useful for elderly subjects and for patients who have other conditions with an oxidative shift… such as coronary heart disease and malignant diseases.”85

[psychejunkie]

 

 

NAC works, i take spectracell bloodtests a couple times a year

 

and u can clearly see the improvement in glutathione after using NAC. I just didnt know that it promotes asthma (if thats true)

Actually NAC promotes Hypoxia and increases every Hypoxic-related gene expression!

 

 

Do you have a reference for this? I have only found positive effects from NAC in published studies, other than anomalies specifically referring to extreme cases of asthma.

 

The Overlooked Compound That Saves Lives

http://www.lifeexten...ysteine/page-01

 

• In one of the original animal studies demonstrating that oxidative stress contributes to development of PAH induced by hypoxia, NAC actually reduced the heart and lung changes that lead to PAH, in part by reducing toxic peroxide molecules.80
• NAC, given before and at the beginning of experimental hypoxia, was effective at preventing PAH, including deadly heart muscle changes, in laboratory rats.82
• NAC protects experimental animals’ lungs from the acute lung injury caused by a variety of mechanisms involving hypoxia, oxidant stress, and inflammation, through its joint antioxidant and anti-inflammatory actions.83,84
• A study of human volunteers revealed that NAC supplements at 1,800 mg/day increased the healthy respiratory response to hypoxia,85 which normally declines strongly with age and may contribute to PAH.86Although this study was cited by the Virginia group as supporting their concern about NAC inducing PAH, no such evidence is presented in the human study, and in fact the authors conclude that NAC treatment “may be useful for elderly subjects and for patients who have other conditions with an oxidative shift… such as coronary heart disease and malignant diseases.”85

 

Yes! I have.

 

https://www.ncbi.nlm...les/PMC1952618/

[YANNO]

All i can say, and its not backed by any science...

 

I know that my glutathione was non existent! when i took the spectracell test and then my nutritionist advised i take:

 

NAC by designsforhealth 1800 mg a day (they have a 900mg version, i took 2 a day) for at least 6 months

when i took the blood test 6-8 months later. My GLutathione was normal again ( i was surprised to be honest)

 

No a days I use the 

Healthy Origins L-Glutathione Natural 500 Mg Reduced, 60 Count

 

BUT i did also get more sensitive to asthma reactions from time to time, it just hit me when i seen this thread and i connected the two. 

 

so i did benefit immensely from the NAC, believe me! it is a powerful supplement, i feel it helps me mentally as one of the best nootropics. Im just worried now about this asthma thing

 

PS. im showing u guys the brands i used because it is very important for me, ive used different types of brands and there is a big difference in quality ( i used to think all vitamins were the same, def not true)

[natasjlp]

 

 

 

NAC works, i take spectracell bloodtests a couple times a year

 

and u can clearly see the improvement in glutathione after using NAC. I just didnt know that it promotes asthma (if thats true)

Actually NAC promotes Hypoxia and increases every Hypoxic-related gene expression!

 

 

Do you have a reference for this? I have only found positive effects from NAC in published studies, other than anomalies specifically referring to extreme cases of asthma.

 

The Overlooked Compound That Saves Lives

http://www.lifeexten...ysteine/page-01

 

• In one of the original animal studies demonstrating that oxidative stress contributes to development of PAH induced by hypoxia, NAC actually reduced the heart and lung changes that lead to PAH, in part by reducing toxic peroxide molecules.80
• NAC, given before and at the beginning of experimental hypoxia, was effective at preventing PAH, including deadly heart muscle changes, in laboratory rats.82
• NAC protects experimental animals’ lungs from the acute lung injury caused by a variety of mechanisms involving hypoxia, oxidant stress, and inflammation, through its joint antioxidant and anti-inflammatory actions.83,84
• A study of human volunteers revealed that NAC supplements at 1,800 mg/day increased the healthy respiratory response to hypoxia,85 which normally declines strongly with age and may contribute to PAH.86Although this study was cited by the Virginia group as supporting their concern about NAC inducing PAH, no such evidence is presented in the human study, and in fact the authors conclude that NAC treatment “may be useful for elderly subjects and for patients who have other conditions with an oxidative shift… such as coronary heart disease and malignant diseases.”85

 

Yes! I have.

 

https://www.ncbi.nlm...les/PMC1952618/

 

From the same study under "Conclusions".

 

https://www.ncbi.nlm...les/PMC1952618/

 

"The effect of chronic NAC exposure to cause pulmonary vascular pathology may be species dependent. It is reassuring that the NAC dose that caused PAH in mice was higher than the hypoxia-mimetic dose used in humans (48). However, PAH can be subclinical, even presenting as a terminal event (7, 8). In this context, it is noteworthy that NAC treatment may fail to decrease mortality in human clinical trials, despite beneficial antiinflammatory and antioxidant effects (30): PAH has not previously been considered as a NAC toxicity. Surveillance for this toxicity may be appropriate for long-term human trials with NAC."

[Ames]

I can feel the pulmonary pathology when I take NAC. It feels like drastically increased pressure, and it certainly isn't a placebo side effect (if that would be possible). This side effect was rather strong and consistent for me. And scary. Without a doubt, the scariest thing that I've experienced in two decades of experimenting with supplements. I would not recommend NAC to anyone.

 

If my goal was to raise glutathione outside of a glutathione supplement, I would take glycine and Whey isolate for the cysteine. I would avoid straight cysteine (personal preference given my reaction to NAC and a potential sour stomach from cysteine).

 

You could even buy powdered beef gelatin, in place of glycine, and add that to the whey for a thicker shake effect to keep it "all(most) natural".

 

I'm taking glycine now with whey isolate, but not necessarily for glutathione production. Though I'll take it. 

 

Whey has the potential to induce insulin resistance in muscle, as the double edged sword for that particular process - (energy in, and resistance to that flow follows).

 

Glycine reverses insulin resistance. A balanced function of protein and glycine (gelatin) seems to be paired in nutrient biology, which makes sense given their proximity in the mammalian body. 

 

I take glycine before whey. If your blood sugar is too low even after the Whey, you may have to add a little maltodextrin or dextrose (or any other carb) to the shake, or take it after, until you can taper it down.

Edited by golgi1, 18 June 2018 - 05:26 PM.