http://mentalhealthd...antidepressant/
i recommend checking the link for full details
i came across this very interiguing novel anti-depressant
As of 2010, researchers discovered a natural peptide called “Spadin” comprised of 17 amino acids with potent, fast-acting antidepressant properties. Spadin is derived from the maturation of NTSR3 (neurotensin receptor 3), also known as “Sortilin.” Sortilin is expressed in the brain, spinal cord, and muscles – and is considered a member of the “Vps10p-domain receptors.”
It is also expressed during embryogenesis in regions influenced by nerve growth factor. Preclinical trials indicate that Spadin provides robust antidepressant efficacy within 4 days of administration. Moreover, it appears as though administration of Spadin produces no significant adverse effects and/or side effects.
The substance elicits its effect primarily by acting as a TREK-1 potassium channel antagonist. Meaning, it inhibits the activation of this channel, and ultimately contributes to an antidepressant effect. Mice with knockout TREK-1 channels have been noted as being immune (or resistant) to developing depression, and among non-knockout mice, administration of Spadin elicits the same effect as a result of its antagonist effect.
all studies relating to it
http://www.ncbi.nlm....pubmed/25080852
http://www.ncbi.nlm....pubmed/25263033
http://www.ncbi.nlm....pubmed/21807005
http://www.ncbi.nlm....pubmed/22022421
http://www.ncbi.nlm....pubmed/20405001
http://www.ncbi.nlm....pubmed/17622574
the one thing that supprised me is this
Inability to patent: There is no major money to be made in natural peptides like Spadin. If there were money to be made, Spadin would’ve likely been patented and formatted into a supplement. However, the big money will be made in the development of chemical analogues, or substances that have similar effects to Spadin. It would be nice if someone reading this had the funds to develop Spadin, test it in humans, and market it as a dietary supplement (assuming it proves effective).
