IP6 ≈ phytic acid = anti-nutrient[1]
Binding of Cu2+, Zn2+, and Cd2+ to Inositol Tri-, Tetra-, Penta-, and Hexaphosphates [additional resource]
myo-Inositol hexaphosphate, the salt of myo-inositol hexaphosphoric acid (IP6), is a common constituent of many plant foods, such as cereals and legumes. IP6 interacts with mineral elements, influencing their bioavailability ...
mineral complex formation with lower inositol phosphates is likely to occur in the duodenum, which would be important from a nutritional point of view. The mineral binding capacity as calculated per phosphate group was similar for IP6, IP5, IP4, and IP3, but the binding strength was lower for the lower inositol phosphates (IP4 and IP3). At increasing pH, within the range (pH 3−7), the metal complex formation generally began in the order copper, zinc, cadmium
As well 5-htp isn't recommended for everyone on the long term because of concerns raised by chronic excess blood serotonin, eg) cardiac valve fibrosis.
I recommend instead Bacopa which increases TPH2, the enzyme which converts tryptophan to serotonin, and SERT, which presynaptically uptakes serotonin for reuse.
Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation
Serotonin is naturally vasoconstrictive, so not to be combined with other vasoconstrictors.
A more obscure herb to consider is Evodiae:
Regulatory effects of Wuzhuyutang (Evodiae prescription) and its consisting herbs on TPH2 promoter.
Or these two:
Rhizoma Coptidis and Fructus Evodiae is explained by modulating the monoaminergic neurotransmitter system in mice [courtesy of Flex]
the alkaloids from the two herbs may provide a protective effect for depression in individuals with a low expressing 5-HTT allele by increasing receptor concentration in serotonergic neurons
Edited by gamesguru, 02 September 2015 - 02:24 AM.