27 replies to this topic

[birthdaysuit]

Could anyone give me input on their experience with,

 

Myo-Inositol, L-theanine, and Reish Mushroom

 

I have tried both Myo-Inositol and L-theanine only a few times and never more than 4 days in a row. The inositol muddled my intrusive thoughts and helped slightly with the onset of panic but gave me severe brain fog, which took atoll on my short term memory. L-theanine made me relaxed, however I have yet to try it in social situations.

[gamesguru]

Green tea (7 cups) modulates serotonin uptake and transport [1].

Ginkgo modulates 5-HT_1A receptor expression and inhibits 5-HT_3A receptors [2, though perhaps only with much more than 240mg of 24%/6%].

Ginseng (Rg₃ from Panax) inhibits 5-HT_3A receptor [3, 4].

Bacopa upregulates SERT.

Berberine activates 5-HT_1A autoreceptors and inhibits receptors 5-HT_1A and 5-HT_2A.

Yohimbine antagonizes 5-HT_1B, and suppresses 5-HT levels through 5-HT_1A[5].

Caffeine antagonizes A_2A receptors [6].

 

Caffeine inhibits exercise-induced elevation in TPH expression

Acorus tatarinowii Schott inhibits exercise-induced synthesis of 5-HT, TPH2 expression and prevents exercise-induced decrease of 5-HT1B expression

[And also St. John's Wort] Rhizoma Coptidis and Fructus Evodiae increase receptor concentration in serotonergic neurons [courtesy of Flex]

 

Magnolol of Lemon Balm enhances pentobarbital-induced sleeping behaviors and increases GABA(A) alpha receptor subunit density
http://www.ncbi.nlm....pubmed/19165750
Anxiolytic-like effects of 4-O-methylhonokiol of Lemon Balm via enhancement of GABAergic transmission and chloride influx
http://www.ncbi.nlm....pubmed/21501091
Neuregulin Induces GABAA Receptor Subunit Expression and Neurite Outgrowth in Cerebellar Granule Cells
http://www.jneurosci.../24/10757.short

 

Epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels

Epicatechin up-regulates GluR2 in cortical neurons and stimulates ERK-dependent cyclic AMP response element activity

Edited by gamesguru, 30 August 2015 - 05:54 PM.

[birthdaysuit]

I suffer from racing, intrusive thoughts, especially in social situations such as college. It is very hard to function when I suffer from this fight and flight response. I’ll sweat, shake and overthink every situation, to the point where I am unable to talk fluently. 

 

I meditate and exercise daily, I’m just looking for something, anything to help mitigate this anxiety. I just want a supplement that helps to relax the mind without causing brain fog. I want to think clearly and fluently again without the jitters and anxiety I get when taking caffeine or Ginkgo or Rhodiola Rosea. 

[birthdaysuit]

Green tea (7 cups) modulates serotonin uptake and transport [1].

Ginkgo modulates 5-HT_1A receptor expression and inhibits 5-HT_3A receptors [2, though perhaps only with much more than 240mg of 24%/6%].

Ginseng (Rg₃ from Panax) inhibits 5-HT_3A receptor [3, 4].

Bacopa upregulates SERT.

Berberine activates 5-HT_1A autoreceptors and inhibits receptors 5-HT_1A and 5-HT_2A.

Yohimbine antagonizes 5-HT_1B, and suppresses 5-HT levels through 5-HT_1A[5].

Caffeine antagonizes A_2A receptors [6].

 

Caffeine inhibits exercise-induced elevation in TPH expression

Acorus tatarinowii Schott inhibits exercise-induced synthesis of 5-HT, TPH2 expression and prevents exercise-induced decrease of 5-HT1B expression

[And also St. John's Wort] Rhizoma Coptidis and Fructus Evodiae increase receptor concentration in serotonergic neurons [courtesy of Flex]

 

Magnolol of Lemon Balm enhances pentobarbital-induced sleeping behaviors and increases GABA(A) alpha receptor subunit density
http://www.ncbi.nlm....pubmed/19165750
Anxiolytic-like effects of 4-O-methylhonokiol of Lemon Balm via enhancement of GABAergic transmission and chloride influx
http://www.ncbi.nlm....pubmed/21501091
Neuregulin Induces GABAA Receptor Subunit Expression and Neurite Outgrowth in Cerebellar Granule Cells
http://www.jneurosci.../24/10757.short

 

Epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels

Epicatechin up-regulates GluR2 in cortical neurons and stimulates ERK-dependent cyclic AMP response element activity

Thanks! Tried Ginkgo, didn’t do much. Green tea exasperates my anxiety. Inositol is the only supplement that mitigates the onset of panicky thoughts and panic attacks. I have better control over them when I take it, of course at the cost of short term memory and brain fog, which makes me question inositol.  

[gamesguru]

Could have been cheaper tea, which is lower in catechins and theanine. You said theanine helps, but you haven't tried it with people yet.

Bacopa is worth trialing, and so is lemon balm.  Perhaps ginseng too, but for most people it causes anxiety.

Inositol also has anti-nutritive and other nasty effects IIRC.

Too much meditation, eg introspection, can be unhealthy.

And do you exercise intensely, at least 30 minutes?

[Keizo]

Stuff that has helped me more or less with anxiety, and has had some immediate effect:

Magnesium (bisglycinate form works for me), bacopa monnieri, low dose selegeline (preferably sublingually at 1.25mg or so. You can just buy the regular pills (Jumex, etc) and put a small drop of water on the desired amount on a spoon, then once dissolved (after 10 minutes) smear the dissolved paste under tongue to sit for 10-20 minutes), Cerebrolysin (try not to mix that one with stimulants, SSRIs, and probably most anything else psychoactive).

 

Other stuff:

"Adaptogen" that isn't as stimulating to me as panax ginseng or gynostemma: Russian ginseng, Schizandra, and Rhodiola rosea ( I only ever tried these 3 in combination).

 

I also heard some good things about passion flower for anxiety. Then there is of course beta-blockers.

Edited by Keizo, 30 August 2015 - 09:03 PM.

[gamesguru]

Magnesium, yes.  I get it from mineral water, hemp protein, and sprouted bread [all remarkable sources].

May as well throw ashwagandha on the list of non-stimulating adaptogens.

[birthdaysuit]

Could have been cheaper tea, which is lower in catechins and theanine. You said theanine helps, but you haven't tried it with people yet.

Bacopa is worth trialing, and so is lemon balm.  Perhaps ginseng too, but for most people it causes anxiety.

Inositol also has anti-nutritive and other nasty effects IIRC.

Too much meditation, eg introspection, can be unhealthy.

And do you exercise intensely, at least 30 minutes?

The green tea was gunstock. So it had to be rather potent. Could you source those claims regarding inostiol. I have heard mixed reviews and I don’t want it to affect my negatively in the long term. 

 

Meditation has made me extremely introspective but it helps to relax me and calm my nerves. 

 

Yes, I exercise intensely 5 days a week for more than 30mins. 

[birthdaysuit]

Magnesium, yes.  I get it from mineral water, hemp protein, and sprouted bread [all remarkable sources].

May as well throw ashwagandha on the list of non-stimulating adaptogens.

Tried Ashwagandha Gaia brand and it made me incredibly fatigued. I was unable to concentrate or think. 

 

I got a whole container of Hemp Protein in my fridge, might as well try it.

[gamesguru]

The green tea was gunstock. So it had to be rather potent. Could you source those claims regarding inostiol.

Meditation has made me extremely introspective but it helps to relax me and calm my nerves. 

 

You mean Gunpowder?  That tends to be higher in caffeine, and slightly lower in catechins than Sencha.  Even so, the type of tea means nothing.  If it's anxiogenic: throw it out, try a new supplier (preferably Japanese), and hope for more relaxing effects.  I've had Senchas that were speedy and jittery (presumably with higher caffeine:catechin or caffeine:theanine ratios), others that were calm and meditative ♥☀☯☮.

 

I mean it's a minor effect, the memory problems are probably a more major issue, but ...

Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of Escherichia coli

myo-Inositol (1,2,3,4,5,6)hexakisphosphate (phytate), the major storage form of phosphorus in plants, has been considered to be an anti-nutrient due to its inhibitory effect on bioavailability of essential dietary minerals (Cheryan, 1980).

 

In regards meditation, this account details Hume's nervous breakdown, precipitated by "morbid introspection":

 

Disease of the Learned

Ernest Campbell Mossner

 

His precipitous abandoning of the law in the spring of 1729 gave David Hume a needed opportunity to exploit the ‘new Scene of Thought’ that had so suddenly and excitingly been opened up to his vision. The course of character improvement that Hume had been putting himself through on the basis of moral maxims from the ancient pagan philosophers he came to recognise, too late, as a contributory factor to the ruining of his health. Morbid introspection may become a variety of auto-intoxication and is curable only by extraordinary effort on the part of the diseased. Hume, apparently, made that effort and regained self-mastery. Unwilling to admit that he might be afflicted with the ‘vapors’ or lowness of spirits, a disease of the mind which he vainly imagined was restricted to the idle rich, Hume became worried over some scurvy spots that broke out on his fingers.

 

[stan08]

 

Magnesium, yes.  I get it from mineral water, hemp protein, and sprouted bread [all remarkable sources].

May as well throw ashwagandha on the list of non-stimulating adaptogens.

Tried Ashwagandha Gaia brand and it made me incredibly fatigued. I was unable to concentrate or think. 

 

I got a whole container of Hemp Protein in my fridge, might as well try it.

 

 

I had the same effect from the Gaia Ashwagandha.  However, the ksm-66 ashwagandha extract (Jarrow and Nutrigold use it) doesn't make me tired.  I just wanted to throw that out there in case you want to give it another shot.

[birthdaysuit]

Today I took 100mg of L-theanine twice daily with caffeine. The initial effects were positive. It engendered feelings of happiness and calmness. My OCD related anxiety was reduced slightly, however taking a 2nd pill in the afternoon without caffeine caused me to become drowsy and sleepy and had zero effect on my social anxiety, no matter how much I put myself out there.  I’m definitely going to try L-theanine and Caffeine again experimenting with various dosages, I was surprised that I didn’t experience the overstimulation and wired tension that comes with taking caffeine.  

 

I’ll be taking l-theanine without caffeine tomorrow and possibly inositol the next day to see if that calms my mind. I also have reishi 10:1 powder  as well as ashwagandha and rhodiola rosea, which I believe is synergistic to caffeine. 

 

I’ll be trying Holy Basil as well. I’m just trying to find something that takes the edge off my anxiety but doesn’t sedate me. 

 

Edited by birthdaysuit, 31 August 2015 - 05:06 PM.

[gamesguru]

Magnesium and kava.  Scienceguy had persuaded me Kava downregulates gaba-a/b, and so is not suitable in the long-term as an anxiolytic, buuuut I'm just reading this on examine:
 

... an extract known as WS1490 should be sought out. 300mg of this extract daily (in three divided doses of 100mg) appears to be reliable and effective for the treatment of anxiety ...

When injected into rats, as little as 20mg/kg mixed kavalactones is able to induce sedative effects^[12] and interactions with the GABA receptors appear to not be the cause for anti-anxiety effects of Kava, as coingestion with benzodiazepine blockers fail to abolish the effects of Kava on anxiety as assessed by time spent in the Open Arms test in rats.

 

 

With good sencha you avoid this problem.  I consume 2 litres strong tea daily, which amounts to 1074mg EGCG, 469mg theanine, 416mg caffeine, and 308mg epicatechin.  Basically a 1:1 theanine:caffiene ratio.  It never makes me drowsy, tho perhaps I could sleep if I wanted.  On the contrary, it's stimulating, and more theanine is called for (perhaps closer to a 1.5:1 or 2:1 ratio.

[bzyb]

Hey dude, I didnt read the whole thread, but its been a long day, need to get some sleep at 6 am. Sometimes I feel the same way. One way is to stop looking at the news, which is meant to sensationalize and cause some of those feelings. I've skimmed and tried a lot of the supps and they didnt help much. Its hard to say what will help you to as everyone has different brains, so try 1 for a while and see what works.

 

Lithium orotate in small doses helps and is supposed to be neuroprotective.  Lots of trytophan/5htp gets serotonin in your system (the symptoms you listed are indicative of low serotonin).  Antihistamines help me quell the fight or flight. Antioxidants such as vitamin c, NAC, glutathione. The one that really helped me was phosphatidyl serine, which lowers cortisol.

 

Last, the tried old true of positive thinking or removing one self from a negative ppl/environment. Good luck man, well to all of us!

[Soul searching]

Inositol also has anti-nutritive and other nasty effects IIRC.

 

 

Do you have a source? I can't find anything about this.

[Soul searching]

Today I took 100mg of L-theanine twice daily with caffeine. The initial effects were positive. It engendered feelings of happiness and calmness. My OCD related anxiety was reduced slightly, however taking a 2nd pill in the afternoon without caffeine caused me to become drowsy and sleepy and had zero effect on my social anxiety, no matter how much I put myself out there.  I’m definitely going to try L-theanine and Caffeine again experimenting with various dosages, I was surprised that I didn’t experience the overstimulation and wired tension that comes with taking caffeine.  

 

I’ll be taking l-theanine without caffeine tomorrow and possibly inositol the next day to see if that calms my mind. I also have reishi 10:1 powder  as well as ashwagandha and rhodiola rosea, which I believe is synergistic to caffeine. 

 

I’ll be trying Holy Basil as well. I’m just trying to find something that takes the edge off my anxiety but doesn’t sedate me. 

 

Read Scienceguy's thread and check each supplement on examine. With some supplements, chronic use is associated with a reduction in anxiety. Inositol for example seems to be very effective after 4 weeks 12g-18g.

[birthdaysuit]

Hey dude, I didnt read the whole thread, but its been a long day, need to get some sleep at 6 am. Sometimes I feel the same way. One way is to stop looking at the news, which is meant to sensationalize and cause some of those feelings. I've skimmed and tried a lot of the supps and they didnt help much. Its hard to say what will help you to as everyone has different brains, so try 1 for a while and see what works.

 

Lithium orotate in small doses helps and is supposed to be neuroprotective.  Lots of trytophan/5htp gets serotonin in your system (the symptoms you listed are indicative of low serotonin).  Antihistamines help me quell the fight or flight. Antioxidants such as vitamin c, NAC, glutathione. The one that really helped me was phosphatidyl serine, which lowers cortisol.

 

Last, the tried old true of positive thinking or removing one self from a negative ppl/environment. Good luck man, well to all of us!

All "news"...video or paper... exist to make money for the owners and to propagate a policy angle supportive of the owners ideas, whether the boss of the news agency or the constrain of a governmental pushed agenda. In this context it is almost impossible for accurate, truthful reports to exist, hence genuine journalism is rare. They are the masters of propaganda. I refuse to watch the news anymore. 

 

Never tried Tryptophan or 5htp. I’ll be taking L-Theanine and inositol 3 to 4 times a week.

 

Inositol also has anti-nutritive and other nasty effects IIRC.

 

 

Do you have a source? I can't find anything about this.

 

I’ll continue to use inositol then. And I have also not found a source regarding Inositol anti-nutritve effects.

Edited by birthdaysuit, 02 September 2015 - 12:39 AM.

[gamesguru]

IP6 ≈ phytic acid = anti-nutrient^[1]

Binding of Cu2+, Zn2+, and Cd2+ to Inositol Tri-, Tetra-, Penta-, and Hexaphosphates  [additional resource]

myo-Inositol hexaphosphate, the salt of myo-inositol hexaphosphoric acid (IP6), is a common constituent of many plant foods, such as cereals and legumes. IP6 interacts with mineral elements, influencing their bioavailability ...

mineral complex formation with lower inositol phosphates is likely to occur in the duodenum, which would be important from a nutritional point of view. The mineral binding capacity as calculated per phosphate group was similar for IP6, IP5, IP4, and IP3, but the binding strength was lower for the lower inositol phosphates (IP4 and IP3). At increasing pH, within the range (pH 3−7), the metal complex formation generally began in the order copper, zinc, cadmium

 

As well 5-htp isn't recommended for everyone on the long term because of concerns raised by chronic excess blood serotonin, eg) cardiac valve fibrosis.

I recommend instead Bacopa which increases TPH2, the enzyme which converts tryptophan to serotonin, and SERT, which presynaptically uptakes serotonin for reuse.

Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation

Serotonin is naturally vasoconstrictive, so not to be combined with other vasoconstrictors.

 

A more obscure herb to consider is Evodiae:

Regulatory effects of Wuzhuyutang (Evodiae prescription) and its consisting herbs on TPH2 promoter.

 

Or these two:

Rhizoma Coptidis and Fructus Evodiae is explained by modulating the monoaminergic neurotransmitter system in mice [courtesy of Flex]

the alkaloids from the two herbs may provide a protective effect for depression in individuals with a low expressing 5-HTT allele by increasing receptor concentration in serotonergic neurons

 

Edited by gamesguru, 02 September 2015 - 02:24 AM.

[birthdaysuit]

 

IP6 ≈ phytic acid = anti-nutrient^[1]

Binding of Cu2+, Zn2+, and Cd2+ to Inositol Tri-, Tetra-, Penta-, and Hexaphosphates  [additional resource]

myo-Inositol hexaphosphate, the salt of myo-inositol hexaphosphoric acid (IP6), is a common constituent of many plant foods, such as cereals and legumes. IP6 interacts with mineral elements, influencing their bioavailability ...

mineral complex formation with lower inositol phosphates is likely to occur in the duodenum, which would be important from a nutritional point of view. The mineral binding capacity as calculated per phosphate group was similar for IP6, IP5, IP4, and IP3, but the binding strength was lower for the lower inositol phosphates (IP4 and IP3). At increasing pH, within the range (pH 3−7), the metal complex formation generally began in the order copper, zinc, cadmium

 

As well 5-htp isn't recommended for everyone on the long term because of concerns raised by chronic excess blood serotonin, eg) cardiac valve fibrosis.

I recommend instead Bacopa which increases TPH2, the enzyme which converts tryptophan to serotonin, and SERT, which presynaptically uptakes serotonin for reuse.

Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation

Serotonin is naturally vasoconstrictive, so not to be combined with other vasoconstrictors.

 

A more obscure herb to consider is Evodiae:

Regulatory effects of Wuzhuyutang (Evodiae prescription) and its consisting herbs on TPH2 promoter.

 

Or these two:

Rhizoma Coptidis and Fructus Evodiae is explained by modulating the monoaminergic neurotransmitter system in mice [courtesy of Flex]

the alkaloids from the two herbs may provide a protective effect for depression in individuals with a low expressing 5-HTT allele by increasing receptor concentration in serotonergic neurons

 

I’ll look into Bacopa monnieriis. Isn’t it fat soluble and would need a lipoid transporter to be absorbed?

 

Heard it tastes terrible. Should I go capsule or powder form?

[gamesguru]

It has better effects for me when eaten with a meal.  IIRC some of anxiolytic compounds are poorly soluble in water, so to elicit the full range of effects, yes it needs to be digested along with a kind of fat.

 

I always prefer powders and avoid capsules, just for purity's sake.

i pour it straight from an amber vial onto my tongue, idgaf about weighing, probly get 500-800mg some days.  have a glass of spring water handy to wash it down, taste shouldn't linger.

nootropicsdepot.com is out of stock currently

if you find another brand and question the quality or want it compared to a third brand, PM me and i could try to give my opinion

Edited by gamesguru, 02 September 2015 - 03:35 AM.

[birthdaysuit]

It has better effects for me when eaten with a meal.  IIRC some of anxiolytic compounds are poorly soluble in water, so to elicit the full range of effects, yes it needs to be digested along with a kind of fat.

 

I always prefer powders and avoid capsules, just for purity's sake.

i pour it straight from an amber vial onto my tongue, idgaf about weighing, probly get 500-800mg some days.  have a glass of spring water handy to wash it down, taste shouldn't linger.

nootropicsdepot.com is out of stock currently

if you find another brand and question the quality or want it compared to a third brand, PM me and i could try to give my opinion

Is this quality Bacoba powder? - http://www.amazon.co...=bacopa organic

 

Also, this - http://www.amazon.co...ncha Green Tea 

 

So today I tool 18grams of inositol in a glass of water without eating. My anxiety still lingered; I felt it, I could feel the onset of panic but I could also easily dismiss it. What I found concerning was that my inner voice was absent. Comparably, when I meditate my inner voice quiets down, however, on inositol I was completely absent of an inner voice. Which scared me a lot. 

 

I also tried around a tablespoon of Reishi 10:1 mushrooms extract that I made into a tea the other night, and it mellowed me out somewhat but what was interesting to me was that I could see clearer and colors were much more saturated. I just want to pick a supplement to use for a full month and see how it affects my anxiety. I just don’t know where to start. 

[birthdaysuit]

It has better effects for me when eaten with a meal.  IIRC some of anxiolytic compounds are poorly soluble in water, so to elicit the full range of effects, yes it needs to be digested along with a kind of fat.

 

I always prefer powders and avoid capsules, just for purity's sake.

i pour it straight from an amber vial onto my tongue, idgaf about weighing, probly get 500-800mg some days.  have a glass of spring water handy to wash it down, taste shouldn't linger.

nootropicsdepot.com is out of stock currently

if you find another brand and question the quality or want it compared to a third brand, PM me and i could try to give my opinion

What do you think of Acetyl L-Carnitine?

[gamesguru]

i like it, but haven't used it in a while.  it upregulates mGluRs, NGF/BDNF, and NE/5-HT.

 

http://www.hardrhino...act-powder.html

http://www.zencha.ne...uct/sencha-moe/

http://purebulk.com/...extract-powder/

[Major Legend]

I use picamilon, and avoid phenibut like a plague...theanine is ridiculously weak for any strong anxiety but mild jitters.

 

Inositol never worked for me. I've tried taurine, magnesium baths and a bunch of other things suggested previously.

Edited by Major Legend, 03 September 2015 - 10:41 PM.

[birthdaysuit]

I use picamilon, and avoid phenibut like a plague...theanine is ridiculously weak for any strong anxiety but mild jitters.

 

Inositol never worked for me. I've tried taurine, magnesium baths and a bunch of other things suggested previously.

Could you give me some information regarding picamilon. Yes, I have noticed that l-theanine is weak, though, it pairs well with caffeine, takes the jitters out and clears you mind but doesn’t really help with generalized anxiety. Inositol works for my OCD, not so much my social anxiety. 

Edited by birthdaysuit, 03 September 2015 - 11:39 PM.

[gamesguru]

magnesium baths

 

heard good things about these!  haven't got round to trying them, regrettably

[gamesguru]

Kava?

A quarter of the kava group reported complete remission in their anxiety symptoms at the end of the trial, compared to 6% of the placebo group ...
interactions with the GABA receptors appear to not be the cause for anti-anxiety effects of Kava, as coingestion with benzodiazepine blockers fail to abolish the effects of Kava on anxiety as assessed by time spent in the Open Arms test in rats.^[16]

 

Picamilon (basics, the punchline is that GABA is is not highly BBB-permeable, whilst picamilion [niacin bond with GABA] is, and within the CNS there are supposedly hydrolytic enzymes which break down the bond):

 Picamilon is able to cross the blood–brain barrier^[5] and then is hydrolyzed into GABA and niacin.^{[citation needed]} The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.^[6] The second released component, niacin acts as a strong vasodilator,^[7] which might be useful for the treatment of migraine headaches.

Edited by gamesguru, 04 September 2015 - 02:38 AM.

[Area-1255]

Yohimbine is unlikely to help with anxiety though it may improve energy and motivation . 

Though it does antagonize 1B/1D receptors which would improve anxiety theoretically, it's alpha-2-antagonistic and GABA inhibitory actions would most likely over-ride that particular part of it's effects..although, ironically, yohimbine actually did somewhat improve my OCD.

Problem is it only lasts for about an hour or so.

 

Inhibition by yohimbine of the calcium-dependent evoked release of [3H]GABA in rat and mouse brain slices in vitro.

Green tea (7 cups) modulates serotonin uptake and transport [1].

Ginkgo modulates 5-HT_1A receptor expression and inhibits 5-HT_3A receptors [2, though perhaps only with much more than 240mg of 24%/6%].

Ginseng (Rg₃ from Panax) inhibits 5-HT_3A receptor [3, 4].

Bacopa upregulates SERT.

Berberine activates 5-HT_1A autoreceptors and inhibits receptors 5-HT_1A and 5-HT_2A.

Yohimbine antagonizes 5-HT_1B, and suppresses 5-HT levels through 5-HT_1A[5].

Caffeine antagonizes A_2A receptors [6].

 

Caffeine inhibits exercise-induced elevation in TPH expression

Acorus tatarinowii Schott inhibits exercise-induced synthesis of 5-HT, TPH2 expression and prevents exercise-induced decrease of 5-HT1B expression

[And also St. John's Wort] Rhizoma Coptidis and Fructus Evodiae increase receptor concentration in serotonergic neurons [courtesy of Flex]

 

Magnolol of Lemon Balm enhances pentobarbital-induced sleeping behaviors and increases GABA(A) alpha receptor subunit density
http://www.ncbi.nlm....pubmed/19165750
Anxiolytic-like effects of 4-O-methylhonokiol of Lemon Balm via enhancement of GABAergic transmission and chloride influx
http://www.ncbi.nlm....pubmed/21501091
Neuregulin Induces GABAA Receptor Subunit Expression and Neurite Outgrowth in Cerebellar Granule Cells
http://www.jneurosci.../24/10757.short

 

Epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels

Epicatechin up-regulates GluR2 in cortical neurons and stimulates ERK-dependent cyclic AMP response element activity