5 replies to this topic

[alc]

Singapore scientists discover rejuvenation factors

 

 

http://www.a-star.ed...on-factors.aspx

 

 

[Mind]

Anyone have any other information about Tcl1 protein.

[alc]

http://www.genecards...p.pl?gene=TCL1A

https://www.wikigene...ene/e/8115.html

http://www.nature.co...l/1204596a.html

 

... or just use google ...

 

https://www.google.c...=utf-8&oe=utf-8

 

 

[Turnbuckle]

The full text of the paper is here.

 

The importance of a similiar protein for stem cells has been known for some time. Mice lacking it die very quickly--

 

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

 

Mutations of the genes encoding APC or beta-catenin in colon carcinoma induce the constitutive formation of nuclear beta-catenin/Tcf-4 complexes, resulting in activated transcription of Tcf target genes. To study the physiological role of Tcf-4 (which is encoded by the Tcf7/2 gene), we disrupted Tcf7/2 by homologous recombination. Tcf7/2-/- mice die shortly after birth. A single histopathological abnormality was observed. An apparently normal transition of intestinal endoderm into epithelium occurred at approximately embryonic day (E) 14.5. However, no proliferative compartments were maintained in the prospective crypt regions between the villi. As a consequence, the neonatal epithelium was composed entirely of differentiated, non-dividing villus cells. We conclude that the genetic program controlled by Tcf-4 maintains the crypt stem cells of the small intestine. The constitutive activity of Tcf-4 in APC-deficient human epithelial cells may contribute to their malignant transformation by maintaining stem-cell characteristics.

 

Nat Genet. 1998 Aug;19(4):379-83

 

I can imagine a longevity protocol involving stimulation of a protein that ramps down mitochondria and creates new stem cells, followed at an interval by C60 administration that ramps them up over baseline, causing those new stem cells to differentiate.

 

There is possibly a non-drug method of increasing the number of stem cells. This would be hypoxia--

 

...direct measurements of tissue oxygen tensions in developing embryos revealed that these tissues demonstrated much lower oxygen tensions than had been presumed (Mitchell and Yochim, 1968). Oxygen measurements of tissues known to harbor stem cells revealed even lower oxygen tensions, and raised the question of whether such an environment was necessary for the niche to maintain stem cells...

 

http://www.sciencedi...934590910003413

 

 

 

and for non-embryos, the diving response, where oxygen metabolism is greatly reduced.

 

Edited by Turnbuckle, 05 September 2015 - 01:19 PM.

[alc]

 

The full text of the paper is here.

 

 

Thanks! - I was multitasking and forgot to add the full text from Cell Reports.

[alc]

 

 

 

There is possibly a non-drug method of increasing the number of stem cells. This would be hypoxia--

 

 

 

Histogen - is using low oxygen to develop their products - might be others that are using it:

 

http://www.histogen.com/technology.htm

 

 

Going back to original post:

 

what can be done in a pragmatical way to implement this discovery into rejuvenation process and accelerate the development?

can we organize something via lifespan.io? anyone can take on the task - maybe Ichor Therapeutics?