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Methylcobalamin makes me very tired and sleepy

b12 methylb12 fatigue methylation

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#1 NeuroNootropic

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Posted 05 September 2015 - 02:26 AM


I'm trying to find a sustainable treatment for my chronic fatigue and sleepiness issue. For all my life I've slept 12 hours and still wake up tired. Caffeine does nothing other than increase physical energy, it does nothing mentally unless I'm taking it with modafinil and/or an MAO-B inhibitor.

 

A lot of people have found success in using methylcobalamin to treat their chronic fatigue and report becoming much more energized after starting it. Yet when I took just 1 mg of oral methylcobalamin, not even sublingually, I became very tired, sluggish, and drowsy. Despite this, I continued taking it for 3 more days hoping it was just a coincidence I became more tired, but the longer I continued taking it the worse the fatigue got. Why is this?

 

Why would methylcobalamin increase fatigue? I've tried this numerous times and each time I take methylcobalamin I experience the same side effects. It doesn't matter if it's oral or sublingual.



#2 gamesguru

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Posted 05 September 2015 - 08:45 AM

 

B12 participates in methylation reactions, along with folate, B6, B3, B2 and methyl donors (TMG, choline, etc.). Do you have an unusual response to any of these?

B12 is a fermented vitamin. There are microbial forms of B12 that are anti-metabolites for humans. These anti-metabolites are supposed to be cleaned out by purification of the fermentation, but maybe they were not in this particular case. If so, switching brands could provide a different response.

B12 is known to produce vivid, vibrant and hyperactive dreams, sometimes even erotic and psychotic. Although this can be entertaining on an occasional basis, it can be exhausting when it is repeated or chronic.

It is also possible that you have an accumulated sleep deficit and the B12 is only enhancing a normal sleep process, or sabotaging a sleep-compensation process (e.g., adrenal activation). If so, the sleepiness effect should attenuate rapidly as you catch up on your sleep (assuming that you lower the dose so as to attenuate excessively vivid dreaming, too).

It is possible that you are merely stimulating melatonin. If so, bright blue-rich lighting might decrease the sleepiness. Blue light exposure in the middle of the day is one treatment for seasonal affective disorder and melatonin attenuation may be one of the associated mechanisms of this effect.

B12 is also an catabolic-aerobic-acidifying vitamin by the classification system of Revici (and acid-ash macrobiotic classification, too). So is B6; all the other Bs are anabolic-anaerobic-alkalinizing. Normally, a catabolic-aerobic-acidifying influence would wake you up and promote alertness. But your experience could be some kind of idiosyncratic response. If so, other unusual responses to similarly or oppositely classified nutrients might be experienced. Similar agents would include B6, magnesium, selenium, cysteine/glutathione, thiosulfate, vitamins D3 and A (not beta-carotene), and polyunsaturated oils (flax and fish). Opposite agents would include B1, B2, B3, B5, folate, salt, vitamins E and K, cholesterol, glycerol, fatty alcohols, and plant greens (especially sea veggies).

http://www.quora.com...-make-me-sleepy

http://www.longecity...ne-here-sleepy/


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