8 replies to this topic

[panhedonic]

I started taking yohimbe, nailed the right dosage and now am...hooked. Well, psychologically, but sex is now so much more enjoyable that I'm afraid I'll stick to it for a while. 

 

So far (at the right doses) I have felt no side-effects (even sleep one hour after ingestion is totally fine) , but I couldn't find reliable information on Google. Anybody knows what the effects of taking yohimbe everyday would be? (I'm taking <10mg yohimbine, sometimes less than 5mg) and I do take the whole bark, standardized to 8% yohimbine.

 

Thanks. 

[Area-1255]

Yohimbine has a biological half-life of about 1.05 hours...but it's hypothesized that the noradrenergic effect will last for up to 6-8 hours afterwards..

This effect is enhanced by caffeine, beta-agonists, phenylephrine derivates (cough syrups etc), MAO-A inhibitors and some amino acid substrates.

Corynanthine and some other alkaloids present in the plant have a average half-life of 28 mins...but it can vary per plant source and person. 

In summary, there are no direct risks continuously taking Yohimbe or Yohimbine, but it must be dosed properly and titrated properly with regard to one's own needs and with respect to the variable circumstances due to it's interaction with a multitude of substances..

 

On average, yohimbe/yohimbine do not have any negative interaction with a lot of common medications or herbs, but they do potentiate SSRI's, adrenergics, will alter the response of dopamine medications (but not necessarily for the worst) and also it's worth noting if you ingest carbs or sweet foods surpassing 15g of carbs that yohimbine, but perhaps not the other alkaloids will lose some of their effects..

 

Under no circumstances should yohimbine or yohimbe be combined with modafanil or beta-blocking drugs...nor should it be used with amphetamines. 

Caffeine can be used but favorably at low doses...and beta-agonists increase the risk of tachycardia with the plant or it's constitutes..but won't necessarily increase blood pressure if alpha-1's are sufficiently blocked.

 

 

https://en.wikipedia...ki/Corynanthine

https://www.ncbi.nlm.../pubmed/2991775

http://www.perflavor.../ps1701431.html

http://www.chemspide...ture.83744.html

 

 

Edited by Area-1255, 10 September 2015 - 04:15 PM.

[panhedonic]

Area-1255, thank you! that's great information, I appreciate the thoroughness!

 

Do you have any personal experience/interest around it?

[Area-1255]

Area-1255, thank you! that's great information, I appreciate the thoroughness!

 

Do you have any personal experience/interest around it?

I don't really like Yohimbe plant extracts; I prefer Yohimbine HCL.

It has interesting effects at higher doses between 17-24 mg..what's interesting to note..is that higher doses of Yohimbine actually lower blood pressure and have an anti-sympathetic property due to increasing 5-HT1A agonism and thus decreasing net serotonin release.

 

This however, does not occur when the receptor is de-sensitized and thus long-term users of SSRI's will probably only get the stimulating effects of Yohimbine. 

 

 

Eur J Pharmacol. 1991 Jun 25;199(2):263-5.

Sympatholytic action of yohimbine mediated by 5-HT1A receptors.

McCall RB1, Harris LT, King KA.

Author information

 

Abstract

The present study determined the mechanism by which yohimbine inhibits sympathetic nerve activity in the anesthetized cat. Low i.v. doses of yohimbine increased inferior cardiac nerve discharge as a result of the alpha 2-adrenoceptor antagonist properties of the drug. Higher doses of yohimbine (0.8-1.6 mg/kg) inhibited sympathetic nerve discharge. The inhibition of nerve activity was reversed by i.v. administration of the 5HT1A receptor antagonist spiperone. Similarly we have previously observed spiperone reversal of the sympatholytic effects of the 5-HT1A agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) but failed to affect nerve activity when given alone. Spiperone failed to reverse the sympatholytic effect of clonidine. These data indicate that high doses of yohimbine inhibit sympathetic nerve activity via a 5HT1A agonist action.

PMID:   1683291   [PubMed - indexed for MEDLINE]

[panhedonic]

Area, I'm not understanding the implications of what you say. What would the effects of high doses be, beyond lowering BP?

[Area-1255]

Area, I'm not understanding the implications of what you say. What would the effects of high doses be, beyond lowering BP?

Of pure YOHIMBINE - the high doses would be hypotensive; lowering blood pressure - unless your receptors are messed up from SSRI"s - then will raise BP irregardless... but of the bark extract - high doses could cause more dramatic tachycardia...honestly, I would just take Primaforce's Yohimbine HCL daily about 12.5 mg / twice a day or 17 mg twice a day if you really want to go hardcore..yohimbe bark extract is difficult to measure and I don't appreciate the other sides from it.

BEHAVIORALLY ; high dose yohimbine would decrease some forms of anxiety but may still make you jittery - some forms of cognitive functioning; primarly motivation would be increased but it's possible it may interfere with common-sense tasks due to adrenaline overload... or the 1A properties... also yohimbine can make you very angry in high doses..so watch out for that... 

 

Other than that ---- it's good stuff...

Edited by Area-1255, 04 October 2015 - 06:01 AM.

[Andrey_81]

I have amazing experience with yohimbine HCL, with only 2,5 mg per day. I cannot imagine how would I react if I take 12,5 mg.. I would probably die  

If I take 2.5 mg I can feel amazing rush of energy, which lasts cca 8 hours. I always take it with coffee and if I take it too late I will for sure experience insomnia. I usually take it as a pre-workout (if I intent to workout at 6 or 7 pm, I take it at 2 or 3

 

I have few side effects. Sometimes I feel cold even though its warm and sunny day or if I workout. Strange. The other side effect is raised anxiety (sometimes) and if I take 2,5 two times per day (5 mg in total) I can feel that me heart is beating like crazy. The sex is amazing, I don't take it to raise the sex drive but when you take this stuff erections are like a rock. This is a nice side effect

 

So, when I want to wake myself up, when I go out and want to stay awake all night, when I want to give 100% during the workout I just take 2,5 mg and the magic happens.

 

Strange, I gave the same pill to my friends (2 of them) and they didn't feel anything at all. Zero effect. One of my friends took 10 mg and he felt nothing. How is this possible? This stuff is the strongest thing I have ever tried and for some people (obviously) it does nothing.

[Leon93]

WebMD lists Yohimbine as being 'possibly unsafe'', with reports of severe side-effects: https://www.webmd.co...ono-759/yohimbe. I'm not sure if these will only happen in higher doses. I have my doubts if Yohimbine should be taken long-term, if taken at all. A higher heart beat (as well as irregular) is also most likely not good from a longevity standpoint.

Edited by Leon93, 09 June 2018 - 03:48 PM.

[Rocket]

WebMD lists Yohimbine as being 'possibly unsafe'', with reports of severe side-effects: https://www.webmd.co...ono-759/yohimbe. I'm not sure if these will only happen in higher doses. I have my doubts if Yohimbine should be taken long-term, if taken at all. A higher heart beat (as well as irregular) is also most likely not good from a longevity standpoint.

WebMD would have problems with most of what we people do here on this site.

Some brands of Yohimbine make me feel ill and some don't.