Why isn't piracetam mentioned? Isn't that the mother of all mitochondrial enhancers?
Then second I would say Methylene blue.
Both are mitochondrial enhancers by clinical proof. And I think both are just that, not much more. Therefore if someone rated them as 'placebo', this person likely just has nothing to improve on his mitochondrial level.
Remember that people like Isochroma (and me), suffer from some sort of chronic fatigue syndrom. Such a state, often involves 'underworking' mitochondria and for those people, I think, these two mentioned mitochondrial enhancers are the way to go. In their case and maybe only in their case, both sublements definitely work.
Unfortunately methylene blue will have side effects on the immune system in the long run, as prolonged consumption significant lowers B-Cells in your system. This is particulary bad when it comes to virus diseases. (Especially bad, since many chronic fatigue syndroms seems to be triggered from viruses like Epstein Barr)
Finally I would like to add that the "boost" a person with not properly working mitochondria gets from such a pure enhancer is not like the boost from a stimulating drug, like caffeine or amphetamine. It is not triggered by a chatecholamine nor serotonin. For me its more like a clear head. Nothing more. Nothing less. Saying its a boost seams therefore to be misleading. I just feel more rejuvenated and clear.
But as I said, if chronic fatigue is not your problem. Don't waste your money on pure mitochondrial enhancers, IMHO.
Edited by RobertPaulsen, 21 November 2015 - 04:04 AM.