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Trichostatin A

progeria heterochromatin gdf11

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#1 Rocket

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Posted 21 September 2015 - 12:15 PM


I wonder why there isn't any discussion of Trichostatin A?  It upregulates the gene responsible for GDF-11 which increases GDF-11, and with Lovastatin was found to reorganize heterochromatin (heterochromatin and aging was recently in the news).



#2 Bonee

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Posted 23 September 2015 - 02:57 PM

Would you please give us the source ?

 

thanks



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#3 Rocket

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Posted 23 September 2015 - 05:45 PM

Would you please give us the source ?

 

thanks

 

There are papers in pubmed.



#4 Rocket

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Posted 24 September 2015 - 07:21 PM

http://www.salk.edu/...p?press_id=2080



#5 Tom Andre F. (ex shinobi)

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Posted 30 November 2015 - 02:46 PM

It does too much (for instance on follistatin) to be sure this drug is safe for human consumption



#6 Rocket

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Posted 02 January 2016 - 12:29 AM

It does too much (for instance on follistatin) to be sure this drug is safe for human consumption

 

What about follistatin?  If it increases muscle, GREAT!  Muscle loss is one of heavy hitters of the aging process.

 

I just read an article from this December that worms given Trichostatin A had their lives and healthspan extended. 


Edited by Rocket, 02 January 2016 - 12:36 AM.


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#7 Rocket

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Posted 14 January 2016 - 12:36 AM

Activation of the Growth-Differentiation Factor 11 Gene by the Histone Deacetylase (HDAC) Inhibitor Trichostatin A and Repression by HDAC3

 

http://mcb.asm.org/c...24/12/5106.full

 

 



#8 Rocket

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Posted 07 July 2016 - 01:22 AM

Trichostatin elongates telomeres in another study:
www.ncbi.nlm.nih.gov/pubmed/24510582

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#9 Sith

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Posted 24 July 2016 - 02:40 PM

Trichostatin is often overlooked in terms of its longevity benefits. In theory, it should be beneficial but it is still a novel drug and not much research has been done into its safety. I would, personally, stay away until more research is done. 







Also tagged with one or more of these keywords: progeria, heterochromatin, gdf11

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