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Nicotinamide Riboside [Curated]

nicotinamide riboside nicotinamide nad boosting charles brenner david sinclair leonard guarente niagen niacinamide nicotinamide mononucleotide

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#1531 stefan_001

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Posted 08 November 2016 - 09:01 PM

Ok got it


Edited by stefan_001, 08 November 2016 - 09:02 PM.

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#1532 Oakman

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Posted 08 November 2016 - 10:21 PM

A robust discussion of cancer and NAD+ levels is very pertinent IMO. As the facts in this matter are far from certain at this point, it only makes sense to look at NAD+ supplementation considering all possible outcomes. I've noted this cancer possibility since I started taking NR, as I've had a small brush with cancer (BCC surgically removed) some years ago. It was not fun, and any cancer is certainly not something I want to be encouraging.

 

Because of that, and being 67, I have added Quercetin (as "EMIQ") and Apigenin, with my NR dose, for some weeks now. They do appear to be very symbiotic acting supplements with NR.

 

Happily, both serve a two fold purpose re: NAD+.  First, they are CD38 inhibitors*, and as CD38 levels rise sharply as we age**, and consume NAD+, they should help keep NAD+ levels from being overly suppressed. Second, they are both shown to possess anti-cancer characteristics***, and IF, IN FACT, heightened NAD+ levels due to supplementation are found to encourage cancers, these compounds could offer some anti-cancer protection. 

 

I'd rather be proactive and potentially prevent disease, than be in reactive mode trying to cure disease.  All with a bonus of higher NAD+ levels with less NR supplementation.

 

* Flavonoid Apigenin Is an Inhibitor of the NAD+ ase CD38 - Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome >  https://dash.harvard....pdf?sequence=1

 

** CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction >   http://www.cell.com/...4131(16)30224-8

 

*** A general overview of Cytotoxicity of dietary flavonoids on different human cancer types > https://www.ncbi.nlm...les/PMC4127821/


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#1533 Harkijn

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Posted 09 November 2016 - 07:59 AM

IMO it is the very essence of this board that we permanently challenge our beliefs. Only doubt and discussion will bring us forward. Issues like the pathogens and the present discussion  will not be resolved in the short term.  We should see them  as items on a list that is checked every time a new piece of research data comes in.  Keep up the good work Bryan, I think we all realize how much effort you put into this.


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#1534 mrkosh1

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Posted 10 November 2016 - 01:22 AM

I tremendously doubt that any specific compound found in nature without human modification will have a high level of anti-aging potential. When I say a high level, I mean the ability to literally transform someone's body backwards to a younger state, inside and out. At this time, my guess is that NR may have some ability, over time, to reverse aging in those with serious disease conditions and to a lesser extent in "healthier" humans. If we are going to try and stick with natural compounds that are reasonably simple to acquire, then we're going to need to utilize "stacks" or "combinations" of these substances to produce synergistic effects.

 

You see, if a sixty year individual can take a supplement and reverse gene expression to that of a twenty year old, that may not be enough (even over a period of months or years) to do more than slow or slightly reverse the LIFETIME of damage that has accumulated in his body. To do that, he'd need even stronger agents to push his gene expression and natural repair mechanisms even further. Perhaps all the way to the amazing regenerative levels of an INFANT!

 

If Chromadex and other companies could acquire the funding, I think testing combinations of NAD+ and Sirt boosting compounds for even more pronounced effects would yield the best results. Of course pushing these natural systems to VERY high levels may cause unintentional side effects or even some harm to the body. But the truth is that thousands and thousands of people have been taking NR for months or years now, and if NR was inducing rapid age reversal we would have heard about it. Instead, we here a lot of stories of reversal of disease conditions and more modest anti-aging potential -- even if stronger than most other supplements.

 

The first NR "stack" I'd be tempted to try would be Nicontinamide Riboside plus R Alpha Lipoid Acid plus Acetyl L Carnitine. My hunch is that if this stack was tested on a group of fifty elderly people for a month compared to an NR alone and a control group, the stack would yield better results.


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#1535 Oakman

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Posted 10 November 2016 - 03:38 AM

   ....  

 

The first NR "stack" I'd be tempted to try would be Nicontinamide Riboside plus R Alpha Lipoid Acid plus Acetyl L Carnitine. My hunch is that if this stack was tested on a group of fifty elderly people for a month compared to an NR alone and a control group, the stack would yield better results.

 

Good thought that. I added ALC to my general health stack that included R-ALA maybe 6 months ago, then began my longevity stack with NR + pterostilbene in August, w/PQQ, EMIQ & Apigenin added recently. Not being the personal experience thread, suffice to say I'd like to think everything I take has benefits, but neither NR nor any one other thing added has turned back the hands of time just yet, maybe slowed it a bit... :)​  but how would I tell? A study w/wo might show differences - would be fun to see exactly what. 


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#1536 stefan_001

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Posted 11 November 2016 - 02:12 PM

I tremendously doubt that any specific compound found in nature without human modification will have a high level of anti-aging potential. When I say a high level, I mean the ability to literally transform someone's body backwards to a younger state, inside and out. At this time, my guess is that NR may have some ability, over time, to reverse aging in those with serious disease conditions and to a lesser extent in "healthier" humans. If we are going to try and stick with natural compounds that are reasonably simple to acquire, then we're going to need to utilize "stacks" or "combinations" of these substances to produce synergistic effects.

 

You see, if a sixty year individual can take a supplement and reverse gene expression to that of a twenty year old, that may not be enough (even over a period of months or years) to do more than slow or slightly reverse the LIFETIME of damage that has accumulated in his body. To do that, he'd need even stronger agents to push his gene expression and natural repair mechanisms even further. Perhaps all the way to the amazing regenerative levels of an INFANT!

 

If Chromadex and other companies could acquire the funding, I think testing combinations of NAD+ and Sirt boosting compounds for even more pronounced effects would yield the best results. Of course pushing these natural systems to VERY high levels may cause unintentional side effects or even some harm to the body. But the truth is that thousands and thousands of people have been taking NR for months or years now, and if NR was inducing rapid age reversal we would have heard about it. Instead, we here a lot of stories of reversal of disease conditions and more modest anti-aging potential -- even if stronger than most other supplements.

 

The first NR "stack" I'd be tempted to try would be Nicontinamide Riboside plus R Alpha Lipoid Acid plus Acetyl L Carnitine. My hunch is that if this stack was tested on a group of fifty elderly people for a month compared to an NR alone and a control group, the stack would yield better results.

 

Personally when I look in the mirror, how I feel, energy, mind I am clearly in a better shape. I have no doubt about that at all. 


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#1537 Nate-2004

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Posted 11 November 2016 - 02:27 PM

 

I tremendously doubt that any specific compound found in nature without human modification will have a high level of anti-aging potential. When I say a high level, I mean the ability to literally transform someone's body backwards to a younger state, inside and out. At this time, my guess is that NR may have some ability, over time, to reverse aging in those with serious disease conditions and to a lesser extent in "healthier" humans. If we are going to try and stick with natural compounds that are reasonably simple to acquire, then we're going to need to utilize "stacks" or "combinations" of these substances to produce synergistic effects.

 

You see, if a sixty year individual can take a supplement and reverse gene expression to that of a twenty year old, that may not be enough (even over a period of months or years) to do more than slow or slightly reverse the LIFETIME of damage that has accumulated in his body. To do that, he'd need even stronger agents to push his gene expression and natural repair mechanisms even further. Perhaps all the way to the amazing regenerative levels of an INFANT!

 

If Chromadex and other companies could acquire the funding, I think testing combinations of NAD+ and Sirt boosting compounds for even more pronounced effects would yield the best results. Of course pushing these natural systems to VERY high levels may cause unintentional side effects or even some harm to the body. But the truth is that thousands and thousands of people have been taking NR for months or years now, and if NR was inducing rapid age reversal we would have heard about it. Instead, we here a lot of stories of reversal of disease conditions and more modest anti-aging potential -- even if stronger than most other supplements.

 

The first NR "stack" I'd be tempted to try would be Nicontinamide Riboside plus R Alpha Lipoid Acid plus Acetyl L Carnitine. My hunch is that if this stack was tested on a group of fifty elderly people for a month compared to an NR alone and a control group, the stack would yield better results.

 

Personally when I look in the mirror, how I feel, energy, mind I am clearly in a better shape. I have no doubt about that at all. 

 

 

This makes sense and I agree with Stefan as well.

 

Also I've already been trying that exact stack for a month in addition to MK-677 and creatine mrkosh1. I'm actually getting some pretty incredible results from it. My lower back pain of 7 years is finally gone, despite my awful mattress which I finally broke down and decided to replace with a tuft and needle. I still wake up with lower back pain but it's gone the instant I get out of bed and gone for the rest of the day. The painlessness has stood out like a sore thumb and I keep expecting to feel it when I do certain things and when I don't, it's like, whoa wtf. Still taking it easy. I lifted more in squats this time than I have in years but I didn't go too far with it.


Edited by Nate-2004, 11 November 2016 - 02:28 PM.

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#1538 stefan_001

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Posted 11 November 2016 - 03:21 PM

These off-topic and other ratings are getting boring and are demotivating. I am going to spend my "off-topic" time elsewhere for a while. Have fun, I will limit myself to reading.


Edited by stefan_001, 11 November 2016 - 03:22 PM.

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#1539 Harkijn

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Posted 11 November 2016 - 03:42 PM

Brian, can you perhaps persuade Longecity to give authorization for  the off-topic rating exclusively to you in your function as moderator? That would necessitate all users who think a post irrelevant to make themselves known, explain  and refer to a thread where they think it should have been posted. The way this rating is used at present is simply extremely unkind and discouraging.


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#1540 Thell

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Posted 11 November 2016 - 05:05 PM

Brian, can you perhaps persuade Longecity to give authorization for  the off-topic rating exclusively to you in your function as moderator? That would necessitate all users who think a post irrelevant to make themselves known, explain  and refer to a thread where they think it should have been posted. The way this rating is used at present is simply extremely unkind and discouraging.

 

I believe the quality of this thread has gone downhill recently. So do others if the ratings are to be believed. In Bryan's own words from just a few days ago '... people please rank the posts.' If there is any question as to what the topic is then I highlight a few points from the original post.

 

  1. This thread encompasses the latest articles on Nicotinamide Riboside, NAD boosting, clinical updates and emerging studies all aimed at the medical uses of the NAD precursors.
  2. In the past we've seen some complaints as we explore and discuss some of the parallel topics and your voices have been noted. Personally I'm not totally Nicotinamide Riboside centric and comments on related current and past NAD precursor studies are welcome but lets keep the topic conversation along the lines of NAD boosting to be true to our readers. Being that we've accumulated a treasure trove of NAD medical articles and studies over the last year many visit this thread to find the latest released publications on this topic and we'll stay true to that focus.

Personally, I take this to mean that the posts not adding to this are indeed off-topic. If no one speaks up by using the ratings then things will end up like in the last thread and if people need to 'qualify' the ratings they give with yet another off-topic post saying the mentioned post is off topic then things get out of hand and we still end up with a thread that doesn't follow the topic.

 

Having said that, this post itself is off-topic (for which I apologize) and I'd mark it as such or I'd rate as agree/disagree and move on happily , knowing I've given feedback to future readers/posters without filling up the inbox of the 77 other followers of this thread. 


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#1541 Harkijn

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Posted 11 November 2016 - 05:23 PM

 

Brian, can you perhaps persuade Longecity to give authorization for  the off-topic rating exclusively to you in your function as moderator? That would necessitate all users who think a post irrelevant to make themselves known, explain  and refer to a thread where they think it should have been posted. The way this rating is used at present is simply extremely unkind and discouraging.

 

I believe the quality of this thread has gone downhill recently. So do others if the ratings are to be believed. 

 

Why believe the ratings? That's the point here! For the rest I agree: posts should be relevant to the topic However if people want to preserve the quality of the thread why don't they come out and make their case? Bryan is perfectly able to decide what is off-topic and to refer peolpe to other threads.

 

 

 

 

 


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#1542 Kevnzworld

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Posted 11 November 2016 - 05:44 PM

SENS have weighed in on NR supplementation with their own analysis of the mouse research on NMN (Posted 23rd November 2015):

http://sens.org/rese...ng-mitochondria


Thanks for finding that. I agree Michael Rae only looked at NR thru the lens of Sinclair's research and possibly only NR venders who have been plagiarizing David Sinclair's work on NMN. Its time to unhitch the Sinclair's caboose form the Nicotinamide Riboside train, its an utter embarrassment.

Rae OMITTED or Failed to find research by:
Anthony A. Sauve WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY
Charles Brenner University of Iowa and Dartmouth
Leonard Guarente Massachusetts Institute of Technology
and a host of many other key researchers and their postdoctoral students who are to numerous to mention. In fact David Sinclair is one of Leonard Guarente's postdoctoral researchers.

Here are some basic NR searches based on:
|| Cornell University || Dartmouth || University of Iowa || Massachusetts Institute of Technology || Washington University || University of Copenhagen || National Institutes of Health || Scripps || Spinal Cord || Neuron || Cockayne Syndrome || Mitochondria || Biogenesis || Sirtuin SIRT || Cancer || Once you know the players or have read one paper and have pulled some keywords you turn up more study reading than you could cover in a week.

Since David Sinclair is associated with Harvard I wanted to see if their NR research is being confused with David Sinclair's work by our current venders. See || Harvard ||

For the most part I'd say no, however I do see some non-study articles mentioning both NR and Harvard and if you poke deeper into the links there is some vague vender associations. One term has bothered me which I think is misleading "fountain of youth" But I don't think David Sinclair ever mentioned it in describing Nicotinamide Riboside or promoted it as such. So to find an association to these claims I ran || David Sinclair Harvard with fountain of youth. || to see what vender turned up. I found one who was almost exclusive in these claims but I refrain from mentioning them because I've challenged them on their claims before. So the association of "fountain of youth," "David Sinclair," AND "Harvard" with Nicotinamide Riboside is the domain of one vender in particular. Sure wish my brand of NR did all that. This is the sort of stuff that warps the public perception and the expectation of the NR molecule. Its over the top marketing period. "Niagen Origins Niagen is a nutritional supplement that was discovered as recently as late 2013 by Dr. David Sinclair of Harvard Medical School whilst performing clinical research on mice." This is so far from the truth it makes me laugh and it gets reproduced as a cut and past misnomer time after time. What isn't true confuses the public and this is at the core of the SENS NR review and in the end ChromaDex isn't policing there own venders by letting this LIE continue.

There is the possibility that Sinclair is allowing the the use of his name in the NR advertising in which case this doesn't bother him but a false hood is still growing.

I just hate when reviewers examine and comment on a field of research with only a cursory glance into what first appeared in their google browser. In this case an advertiser who has jumbled up the facts and has portrayed it origins incorrectly. From his review its obvious Michael Rae either didn't bother to find more research pointing to Nicotinamide Riboside than David Sinclair's work on NMN, Niagen vender claims or he intentionally omitted a plethora of NR research to reach his conclusion. Now I don't believe he omitted anything intentionally but I'd have to grade his review on the NR topic as an F for his research effort. I'm speculating he found the aforementioned vender claims and immediately called foul without checking further. I'm kind of disappointed to hear he is a research assistant at the SENS Foundation because its obvious he isn't an unbiased researcher and was quickly opinionated and stopped reading.

This is why I have such a strong opinion about not reading venders marketing claims. Sure they condense a lot of material and you get it fast but they do it in a loose fashion. Who are you going to believe the guy with a Bachelor of Arts in Marketing or someone from our esteemed list above?

I just did an open Nicotinamide Riboside search and could see your standard BS vender claims but there was one bonafide NIH research paper that appeared on page one. I repeated the search with one extra word to exclude the venders "nicotinamide riboside scholarly" and that cleaned up the whole picture.

Some one should point him here. LOL
http://www.longecity...ws-and-updates/

Michael Rae is biased. He only believes in CR as an anti aging protocol. He dismisses research that doesn't fit his world view.
The study that showed that diabetic people on Metformin outlived non diabetics being one example.
He has not read or studied the research on NR/NAD .
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#1543 Kevnzworld

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Posted 11 November 2016 - 05:50 PM

I've been a long time lurker on this thread, I get email updates for every post and I've followed this topic closely.
I want to give Kudo's to Bryan. What he's doing isn't easy. I for one get annoyed with those that continually try to hijack the thread with their own pet topics. He's done a fair and necessary job as moderator.
Start your own thread topic f you don't like Bryan's focus.
I've been taking 500 mg per day in divided doses. I altered my intake to 250mg twice a day after watching Bryan's interview.
Ok, all that being said I'll go back to reading to the updates unless I have something useful to add......
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#1544 stefan_001

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Posted 11 November 2016 - 06:17 PM

I've been a long time lurker on this thread, I get email updates for every post and I've followed this topic closely.
I want to give Kudo's to Bryan. What he's doing isn't easy. I for one get annoyed with those that continually try to hijack the thread with their own pet topics. He's done a fair and necessary job as moderator.
Start your own thread topic f you don't like Bryan's focus.
I've been taking 500 mg per day in divided doses. I altered my intake to 250mg twice a day after watching Bryan's interview.
Ok, all that being said I'll go back to reading to the updates unless I have something useful to add......

 

I said I would take a break from this thread but this one I cannot really let go past. So you are lurking, dont contribute to the research, hypothesis making or trying to formulate a conclusion but yet seem to assume the right to be annoyed about people that contribute items you dont like? Wow it really seems I made the correct conclusion to stop spending time on this.


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#1545 prophets

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Posted 11 November 2016 - 07:05 PM

Michael Rae is biased. He only believes in CR as an anti aging protocol. He dismisses research that doesn't fit his world view.

The study that showed that diabetic people on Metformin outlived non diabetics being one example.
He has not read or studied the research on NR/NAD .

 

 

 

Michael Rae is certainly very opinionated.  He has a very strong view of CR vs. "everything else", but he seems pretty data driven.  His opinions aren't without merit.  In a message forum full of incomplete information and an Internet full of hucksters pushing supplements, I think his thought process is excellent, even if he seems somewhat close minded on non-CR interventions given the high threshold of "proof" he seems to require.

 

 

That metformin study has been called into question for its statistical validity and Michael Rae noted this here.

 

 

Michael Rae has written on the NR/NAD phenomenon and you can read some of his (dated) remarks here.  It'd be interesting to see if he had updated thoughts and was following some of the more recent publications like Zhang, Auwerx (2016), et. al. that seem to indicate life extension properties.

 

krwBVJi.png

 

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., & Luan, P. et al. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science352(6292), 1436-1443. doi:10.1126/science.aaf2693
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#1546 Bryan_S

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Posted 11 November 2016 - 07:15 PM

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

http://onlinelibrary.../hep.28912/full

Authors
Sarmistha Mukherjee,
Karthikeyani Chellappa,
Andrea Moffitt,
Joan Ndungu,
Ryan W. Dellinger,
James G. Davis,
Beamon Agarwal,
Joseph A. Baur
Accepted manuscript online: 3 November 2016Full publication history
DOI: 10.1002/hep.28912View/save citation
Cited by: 0 articlesCitation tools
Abstract
 
The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabolic competition for precursors. To test whether NAD availability restricts the rate of liver regeneration, we supplied nicotinamide riboside (NR), an NAD precursor, in the drinking water of mice subjected to partial hepatectomy. NR increased DNA synthesis, mitotic index, and mass restoration in the regenerating livers. Intriguingly, NR also ameliorated the steatosis that normally accompanies liver regeneration. To distinguish the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme for NAD synthesis, specifically in the liver. Nampt overexpressing mice were mildly hyperglycemic at baseline and, similarly to the mice treated with NR, exhibited enhanced liver regeneration and reduced steatosis following partial hepatectomy. Conversely, mice lacking Nampt in hepatocytes exhibited impaired regenerative capacity that was completely rescued by administering NR.
 
Conclusion: NAD availability is limiting during liver regeneration and supplementation with precursors such as NR may be therapeutic in settings of acute liver injury.

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#1547 Harkijn

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Posted 11 November 2016 - 07:29 PM

 

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

http://onlinelibrary.../hep.28912/full

Authors
Sarmistha Mukherjee,
Karthikeyani Chellappa,
Andrea Moffitt,
Joan Ndungu,
Ryan W. Dellinger,
James G. Davis,
Beamon Agarwal,
Joseph A. Baur
Accepted manuscript online: 3 November 2016Full publication history
DOI: 10.1002/hep.28912View/save citation
Cited by: 0 articlesCitation tools
Abstract
 
The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabolic competition for precursors. To test whether NAD availability restricts the rate of liver regeneration, we supplied nicotinamide riboside (NR), an NAD precursor, in the drinking water of mice subjected to partial hepatectomy. NR increased DNA synthesis, mitotic index, and mass restoration in the regenerating livers. Intriguingly, NR also ameliorated the steatosis that normally accompanies liver regeneration. To distinguish the role of hepatocyte NAD levels from any systemic effects of NR, we generated mice overexpressing Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme for NAD synthesis, specifically in the liver. Nampt overexpressing mice were mildly hyperglycemic at baseline and, similarly to the mice treated with NR, exhibited enhanced liver regeneration and reduced steatosis following partial hepatectomy. Conversely, mice lacking Nampt in hepatocytes exhibited impaired regenerative capacity that was completely rescued by administering NR.
 
Conclusion: NAD availability is limiting during liver regeneration and supplementation with precursors such as NR may be therapeutic in settings of acute liver injury.

 

Also take a look at the extrapolation to human use by the Timeless Life website. Those who are hoping for age reversal (as against longevity) may find his dosage calculation useful.


Edited by harkijn, 11 November 2016 - 07:30 PM.

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#1548 Bryan_S

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Posted 11 November 2016 - 07:43 PM

ChromaDex Announces the Results of Pre-IND meeting for Nicotinamide Riboside for Cockayne Syndrome

https://globenewswir...e-Syndrome.html

 

 

http://investors.chr...rol-newsarticle


Edited by Bryan_S, 12 November 2016 - 05:28 PM.

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#1549 Kevnzworld

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Posted 12 November 2016 - 02:33 AM

I've been a long time lurker on this thread, I get email updates for every post and I've followed this topic closely.
I want to give Kudo's to Bryan. What he's doing isn't easy. I for one get annoyed with those that continually try to hijack the thread with their own pet topics. He's done a fair and necessary job as moderator.
Start your own thread topic f you don't like Bryan's focus.
I've been taking 500 mg per day in divided doses. I altered my intake to 250mg twice a day after watching Bryan's interview.
Ok, all that being said I'll go back to reading to the updates unless I have something useful to add......


I said I would take a break from this thread but this one I cannot really let go past. So you are lurking, dont contribute to the research, hypothesis making or trying to formulate a conclusion but yet seem to assume the right to be annoyed about people that contribute items you dont like? Wow it really seems I made the correct conclusion to stop spending time on this.

I read every post ( lurker ) because I follow this thread. Every post shows up in my email inbox. I don't like my time wasted with off topic posts ( like this one ). I don't personally contribute unless I have something informative to add. That doesn't make my opinion immaterial.
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#1550 Iporuru

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Posted 12 November 2016 - 09:49 AM

http://www.freepaten...16/0317420.html

 

"It is known that niacinamide (CAS No. 98-92-0) and nicotinamide riboside, which are both NAD+ precursors, can be used to modulate the NAD+ pathway to treat cells for some of the symptoms commonly associated with aging. It is also known that niacinamide can improve the appearance of sallow skin by suppressing glycation. Prior to the present invention, it was not known whether nicotinamide riboside could provide a similar benefit, since it has been demonstrated that niacinamide and nicotinamide riboside impact skin biochemistry differently, namely biochemical pathways related to skin pigmentation, ARE modulation and glycolytic ATP depletion. It has now been discovered that nicotinamide riboside can suppress glycation in skin and reduce yellowness associated with glycation. Surprisingly, it has also been discovered that nicotinamide riboside can reduce skin yellowness in skin exposed to environmental stressors such as cigarette smoke. Without intending to be bound by theory, it is believed that nicotinamide riboside blocks an inflammatory pathway linked to the release of the High Mobility Group Box 1 (“HMGB 1”) in keratinocytes exposed to environmental stressors. HMGB 1 release is known to recruit neutrophils, which in turn are known to release factors such as reactive oxygen species, which participate in the sugar rearrangement/crosslinking reaction associated with glycation."


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#1551 Harkijn

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Posted 12 November 2016 - 10:05 AM

 

I read every post ( lurker ) because I follow this thread. Every post shows up in my email inbox. I don't like my time wasted with off topic posts ( like this one ). I don't personally contribute unless I have something informative to add. 

 

 

 

I do not want to prolong this altercation and the following is sincere advice. I agree that notifications can build up stress.  Therefore in our profiles we can adjust the notification options to, for instance, daily.


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#1552 albedo

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Posted 14 November 2016 - 09:48 AM

Can possibly add to the discussion on cancer (see a couple of pages before this one):

 

"Some tumor cells are known to have a higher capability to synthesize NAD, so we were concerned that giving NMN might increase cancer incidence," Imai said. "But we have not seen any differences in cancer rates between the groups."

https://www.scienced...61027122047.htm


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#1553 albedo

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Posted 14 November 2016 - 10:09 AM

 

Jobs / Job post

Post-doc/Associate Specialist - NAD+ Metabolism

PostDoc Position
Posted on 04 Nov 2016
 
 

 

 

Interesting Bryan. I am sure you and others are aware Nestlè (and its branch NIHS) is between the sponsors of the LISP lab of Prof. Auwerx at EPFL which I am following. I am sure you know he was awarded the Marcel Benoist prize which is considered kind of Swiss Nobel Prize. I was at the award ceremony and had a chat with some of the folks;  felt both the momentum and the scientific production is pretty high. In his slides he quoted both the Canto et al work published in Cell on NR and the more recent work on Urolithin A.


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#1554 bluemoon

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Posted 14 November 2016 - 02:10 PM

Any idea what kind of product that Nestle would put NR into? I just read on wiki that they also make medical food. I've wondered the same thing about P&G. 



#1555 Bryan_S

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Posted 14 November 2016 - 07:13 PM

 

A vitamin could help treat Duchenne muscular dystrophy

http://actu.epfl.ch/...muscular-dystr/

 

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

http://stm.sciencema.../8/361/361ra139

 

I didn't see much interest in this publication when albedo and I reviewed it but here is a recent followup article that breaks it down into bit sized pieces.

 

A Vitamin Could Help Treat Duchenne Muscular Dystrophy

Last updated Nov. 14, 2016
"Reversing course with a vitamin: nicotinamide riboside successfully tested on animals"
 
THE MENZIES LAB
Metabolic Diseases and Aging
Selected Publications: http://keirmenzieslab.com/research/
Interesting list of NR/NAD/SIRT publications this group is associated with.

Edited by Bryan_S, 15 November 2016 - 03:13 PM.
THE MENSES LAB added

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#1556 Bryan_S

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Posted 15 November 2016 - 10:22 PM

Thesis defense Thursday 1 December 2016 17:00 BCH 1103

By Aleksandra KONOVALOVA
 
Thesis director : Prof. E. Dubikovskaya
Chemistry and Chemical Engineering doctoral program.
Thesis 7139
 
Accessibility General public
 
Admittance Free
 
In searching ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE EPFL for the thesis I found they've filed a few studies I hadn't seen on nicotinamide riboside. So we have another research source. https://search.epfl....e&origin=header
 
One video also turned up thru their search engine (in French).
Une vitamine qui empêche le vieillissement
SCIENCES - 11/05/16
Une vitamine qui empêche le vieillissement des organes : c’est la découverte faite par des chercheurs de l’EPFL. La nicotinamide riboside pourrait donc permettre de vivre mieux et plus longtemps.

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#1557 midas

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Posted 16 November 2016 - 12:52 AM

"Says FDA has indicated it will consider a fast track designation for Nicotinamide Riboside at time of IND submission" (Nicotinamide Riboside for cockayne syndrome)

 

http://www.reuters.c...e/idUSFWN1DC0VQ

 

-----------------------------------------------------------------------------------------------------------------------------

 

Proctor and Gamble file for patent...

 

http://www.freepaten...16/0317419.html

 

-----------------------------------------------------------------------------------------------------------------------------


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#1558 Oakman

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Posted 16 November 2016 - 03:57 PM

...

 

Proctor and Gamble file for patent...

 

http://www.freepaten...16/0317419.html

 

-----------------------------------------------------------------------------------------------------------------------------

 

Briefly read that application and wow, can they really patent so broadly? They cover virtually any topical formulation of NR and other substances possible, in any amount, for any period of time. They also talk about oral supplementation along with the topical. Not sure, but can that be part of the patent as well? Hopefully not, or everyone else selling NR is going to be left high and dry.

 

Anyone a patent expert?


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#1559 HappyPaul

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Posted 16 November 2016 - 05:50 PM

 

...

 

Proctor and Gamble file for patent...

 

http://www.freepaten...16/0317419.html

 

-----------------------------------------------------------------------------------------------------------------------------

 

Briefly read that application and wow, can they really patent so broadly? They cover virtually any topical formulation of NR and other substances possible, in any amount, for any period of time. They also talk about oral supplementation along with the topical. Not sure, but can that be part of the patent as well? Hopefully not, or everyone else selling NR is going to be left high and dry.

 

Anyone a patent expert?

 

I'm not an expert but I believe there are patent applications preceding this dealing with skin.  The patent I am truly interested in is if Cromadex has one in the drug pipeline for NR treating Neuropathy.  I think they do but not 100% sure.  If this evolves into an drug fighting Neuropothy which is so prevalent with type II diabetes in the US, we are talking billions if not tens of billions. 



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#1560 Bryan_S

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Posted 16 November 2016 - 06:17 PM

 

Proctor and Gamble file for patent...

 

http://www.freepaten...16/0317419.html

 

 

Great find! At the moment NR is only stable as a salt. Do we see a water or emulsive base for NR yet? When this happens watch out. 







Also tagged with one or more of these keywords: nicotinamide riboside, nicotinamide, nad boosting, charles brenner, david sinclair, leonard guarente, niagen, niacinamide, nicotinamide mononucleotide

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