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Nicotinamide Riboside [Curated]

nicotinamide riboside nicotinamide nad boosting charles brenner david sinclair leonard guarente niagen niacinamide nicotinamide mononucleotide

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#1861 soulprogrammer

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Posted 20 March 2017 - 03:00 PM

Is this old news?

 

Nicotinamide riboside or IL-17A signaling blockers to prevent liver disorders Ana Teijeiro and Nabil Djouder

 

dated Jan 2017

 

http://www.impactjou...s/1/338/338.pdf


  • Informative x 1

#1862 MikeDC

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Posted 20 March 2017 - 11:58 PM

This is new. Although there was an earlier publication that showed Nicotinamide Riboside prevented and cures liver and other cancers.

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#1863 Bryan_S

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Posted 21 March 2017 - 01:10 AM

Edited Transcript of CDXC earnings conference call or presentation 17-Mar-17 5:00pm GMT

http://finance.yahoo...-194054556.html


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#1864 Kirito

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Posted Yesterday, 10:01 PM

Critical step in DNA repair, cellular aging pinpointed

"experiments conducted in mice show that treatment with the NAD precursor NMN mitigates age-related DNA damage and wards off DNA damage from radiation exposure."

 

https://www.scienced...70323150518.htm

 

 


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#1865 Kirito

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Posted Yesterday, 11:17 PM

NAD+ binding modulates protein interactions

"An unexpected function of the oxidized form of nicotinamide adenine dinucleotide (NAD+) could underlie some effects of aging and propensity to age-related diseases. Li et al. found that the protein DBC1 (deleted in breast cancer 1) contains a domain that specifically binds NAD+. Binding of NAD+ inhibited the interaction of DBC1 with PARP1 [poly(adenosine diphosphate–ribose) polymerase 1], an enzyme important in DNA repair. Activity of PARP1 is inhibited by interaction with DBC1. Thus, the reduced abundance of NAD+ associated with aging may decrease PARP1 activity by promoting the interaction of PARP1 with DBC1. This mechanism could help explain the reported rejuvenating actions of NAD+ supplementation in older animals."

 

http://science.scien...t/355/6331/1312

 

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#1866 APBT

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Posted Yesterday, 11:51 PM

NAD+ binding modulates protein interactions

"An unexpected function of the oxidized form of nicotinamide adenine dinucleotide (NAD+) could underlie some effects of aging and propensity to age-related diseases. Li et al. found that the protein DBC1 (deleted in breast cancer 1) contains a domain that specifically binds NAD+. Binding of NAD+ inhibited the interaction of DBC1 with PARP1 [poly(adenosine diphosphate–ribose) polymerase 1], an enzyme important in DNA repair. Activity of PARP1 is inhibited by interaction with DBC1. Thus, the reduced abundance of NAD+ associated with aging may decrease PARP1 activity by promoting the interaction of PARP1 with DBC1. This mechanism could help explain the reported rejuvenating actions of NAD+ supplementation in older animals."

 

http://science.scien...t/355/6331/1312

 

The full text appears to require membership.

 

 

FULL TEXT:

Attached Files


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#1867 me2

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Posted Today, 04:36 AM

A "new" discovery... ?

 

https://medicalxpres...aging.html#nRlv

 

"Human trials with NMN therapy will begin within six months" at Brigham and Women's Hospital in Boston.



#1868 soulprogrammer

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Posted Today, 07:22 AM

A "new" discovery... ?

 

https://medicalxpres...aging.html#nRlv

 

"Human trials with NMN therapy will begin within six months" at Brigham and Women's Hospital in Boston.

 

Indeed, I believe the "discovery" happened few years back. Only more elaborate theory now how it works? A new paper for similar content, similar experiment.... This happens a lot to nowadays professors...keep publishing the same content (twisting a bit only) on several journals/conferences...



#1869 Harkijn

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Posted Today, 07:34 AM

 

NAD+ binding modulates protein interactions

"An unexpected function of the oxidized form of nicotinamide adenine dinucleotide (NAD+) could underlie some effects of aging and propensity to age-related diseases. Li et al. found that the protein DBC1 (deleted in breast cancer 1) contains a domain that specifically binds NAD+. Binding of NAD+ inhibited the interaction of DBC1 with PARP1 [poly(adenosine diphosphate–ribose) polymerase 1], an enzyme important in DNA repair. Activity of PARP1 is inhibited by interaction with DBC1. Thus, the reduced abundance of NAD+ associated with aging may decrease PARP1 activity by promoting the interaction of PARP1 with DBC1. This mechanism could help explain the reported rejuvenating actions of NAD+ supplementation in older animals."

 

http://science.scien...t/355/6331/1312

 

The full text appears to require membership.

 

 

FULL TEXT:

 

A question to those who are able to read the data in this study: at first the researchers compared the effects of NMN as well as NR.

Then they hypothesize that ' a cause (of aging) may be increased binding of DBC1 to PARP1 as NAD+ levels decline during aging. To test this, we examined the effect of NMN treatment on young and old mice.'

They do not motivate their decision to choose for testing with NMN and not with NR.  Is there anything in the data that makes it obvious to choose for NMN?



#1870 soulprogrammer

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Posted Today, 08:24 AM

"They do not motivate their decision to choose for testing with NMN and not with NR.  Is there anything in the data that makes it obvious to choose for NMN?"

 

If I'm Sinclair, I will also choose NMN, Sinclair wont make a dime if NR sells more because of this experiment! 


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#1871 Harkijn

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Posted Today, 09:23 AM

"They do not motivate their decision to choose for testing with NMN and not with NR.  Is there anything in the data that makes it obvious to choose for NMN?"

 

If I'm Sinclair, I will also choose NMN, Sinclair wont make a dime if NR sells more because of this experiment! 

You certainly have a point but it is not  the whole picture. If this group had wanted to 'boycot' NR, they would not have used it at all in the first place. So my question remains valid: is there anything in this research that makes NMN the logical choice above NR for testing and replication?


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#1872 stefan_001

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Posted Today, 10:01 AM

"They do not motivate their decision to choose for testing with NMN and not with NR. Is there anything in the data that makes it obvious to choose for NMN?"

If I'm Sinclair, I will also choose NMN, Sinclair wont make a dime if NR sells more because of this experiment!

You certainly have a point but it is not the whole picture. If this group had wanted to 'boycot' NR, they would not have used it at all in the first place. So my question remains valid: is there anything in this research that makes NMN the logical choice above NR for testing and replication?


concentration: 500 mg/kg per day intraperitoneally

Edited by stefan_001, Today, 10:03 AM.


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#1873 VP.

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Posted Today, 05:31 PM

The Daily Mail has an exclusive story about Sinclair's NMN trial. Sensational as usual. 

 

Would YOU choose to live forever? Age-reversing pill that Nasa wants to give to astronauts on Mars will begin human trials within six months

The experiments in mice, from a team at the University of New South Wales, suggest a treatment is possible for DNA damage from ageing and radiation.

It is so promising it has attracted the attention of Nasa scientists in their quest to reach Mars.

While our cells can naturally repair DNA damage - such as damage caused by the sun - this ability declines with age.

The scientists identified that the call signalling molecule NAD+, which is naturally present in every cell in the body, has a key role in protein interactions that control DNA repair.

Treating mice with an NAD+ 'booster' called NMN improved their cells' ability to repair DNA damage caused by radiation exposure or old age. 

Human trials of NMN therapy will begin within six months. 

http://www.dailymail...six-months.html

 







Also tagged with one or more of these keywords: nicotinamide riboside, nicotinamide, nad boosting, charles brenner, david sinclair, leonard guarente, niagen, niacinamide, nicotinamide mononucleotide

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