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A Map of Currently Available Life Extension Methods

life extension immortality

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#1 turchin

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Posted 23 October 2015 - 02:41 PM


A map of currently available life extension methods

 

Extremely large payoff from life extension

We live in special period of time when radical life extension is not far. We just need to survive until the moment when all the necessary technologies will be created.

The positive scenario suggests it could happen by 2050 (plus or minus 20 years), when humanity will create an advanced and powerful AI, highly developed nanotechnologies and a cure for aging.

Many young people could reach the year 2050 without even doing anything special.  

But for many other people an opportunity to extend their life for just 10-20 years is the key to achieving radical life extension (at least for a thousand of years, perhaps even more), because they will be able to survive until the creation of strong life extension technologies.

That is why even a slight life extension today means a potentially eternal prize. This map of the currently available life extension methods could help in it. The map contains a description of the initial stage of plan A from the “Personal Immortality Roadmap” (where plan B is cryonics, plan C – digital immortality and plan D – quantum immortality).

Brain is most important for life extension

The main idea of this map is that all efforts towards life extension must start from our brain, and in fact, they must finish there too.

First of all, you must have the will to conquer aging and death, and do it using scientific methods.

This is probably the most difficult part of the life extension journey. The vast majority of people simply don't think about life extension, while those who do care about it (usually when it's too late) use weak and non-scientific ways and methods; they simply don't understand that the prize of this game is not ten of healthy latter years, but almost eternal life. 

Secondly, you need to develop or mobilize the qualities inside yourself which are necessary for simple, daily procedures, which can almost guarantee life extension by an average of 10-20 years. e.g. avoiding smoking and alcohol consumption, daily mobility, daily intake of medicines and dietary supplements.

Most people find it incredibly difficult to perform simple actions on a permanent basis, for example even taking one pill every day for a year would be too much for most people. Not to mention quitting smoking or regular health check-ups. 

A human who has the motivation to extend his life, a proper understanding of how to achieve it and the necessary skills to realize his plans, should be considered as almost a superman. 

On other hand, while all of our body systems are affected by aging, our brain damage during aging plays the biggest role in total productivity reduction. Even though our crystallized intelligence increases with age, our fluid intelligence, our memory, and the possibility of making radical changes and acquiring new skills all decrease significantly with aging.

And these abilities decrease at the very time when they are needed most – to fight the aging process! Young people usually don't care too much about the aging process, because it's beyond their planning horizon. These qualities are vital in order to build the motivation and skills required to maintain health. 

Thus, this leads to the idea of the map, which says that all main efforts to combat aging must be focused on brain aging. If you can keep your brain youthful, it will create and implement new skills to extend your life, helping you to find new information in a sea of new publications and technologies.

If Alzheimer’s is the first sign of aging to reach your body, you will have to crawl for a tablet of validol without even knowing that it is harmful. And even worse, you will crystallize some harmful beliefs. A person can think that he is a genius in some fields, receive approval from others, but continue his journey in the wrong direction – in the direction of death. (Of course early detection of cancer and a healthy heart are really important to extend your life, but it will be too difficult to deal with such problems if your brain is not working properly).

The second reason to invest in brain health and regeneration is a direct connection of its state with the state of many other systems in your body through nervous and hormonal connections. 

In order to preserve your brain health we have to use antidepressants, nootropics and substances which promote its regeneration.

The example of Rita Montalchni is interesting.

 (https://en.wikipedia.org/wiki/Rita_Levi-Montalcini). She administered a nerve growth factor (NGF) as eye drops and lived for 103 years and was productive as a scientist. She lived 12 years longer than her twin sister, that has very low probability (around 0.001) for her age if we take in account steepness of Hompertz curve in the age near 100. Unfortunately not much research was done about effects of NGF on life extension, as well as effect of other substances.

The idea of preventing personal brain aging and using results of it to study new methods of life extension and brain aging prevention is similar to idea of AI which is using all his resources for self-improvement. But in this case it is more like preventing decline.

The map consists of 5 steps

Step 1. Motivation. Without motivation to extend personal life span no action is possible. A person should understand that there is a problem of personal aging and it is possible to fight this it, using rational approaches.

Step 2. Self-organisation. Any decision is useless without ability to hold it and perform consistently needed actions. So step 2 is about creating life extension mindset and needed abilities to make small actions everyday.

Step 3. Preventing immediate risks. Many people die not because of aging but because of drinking, car crashes, violence, untreated illnesses and large part of such accidences is preventable. So one need to check his risks and prevent most dangerous of them. Only after it fighting aging is reasonable.

Step 4. Brain health. Now one has 20-50 years of life expectancy, but much less of agile and workable brain life expectancy. So it is wise to invest in preventing brain decline first. It consists of fighting depression (and other brain disorders), preventing brain aging and brain regeneration. But in fact most of these substeps could be reduced to one action as for example most antidepressant work by increasing brains growth factors, which results in growing more new brain cells in hippocampus and more dendrites of existing neurons. This TED talk explains details: http://www.ted.com/t...ells_here_s_how

Step 5. Fighting aging. Now you have time for more long term projects. This step consists of lifestyle block, medicine block and antiaging interventions block. The last one include supplements, drug and nutrition part and other methods part, which has sport, hormesis, sleep and parameters control.

The last map block is reminder about importance of cryonics and digital immortality.

Collective efforts in life extension

This map doesn't include one really important social aspect of aging prevention. If we could absorb all the money (through crowdfunding), which people use to buy supplements (around 300 billion per year), and use it to perform experiments in the field of life extension instead, we could invent new anti-aging medicine and other life extension tools. These methods and medicines could be used by those who initially donated money for such experiments; they could also benefit from sales of such products. Thus, such crowdfunding would include IPO too.

You won't find other social aspects in the map such as promotion of the idea of the fight against aging, political activism and art. All of these aspects are mentioned in the main Immortality Roadmap.

The map also doesn't include a temporal aspect. Our knowledge about the best methods of life extension changes almost daily. This map contains ideas which are valid in 2015, but it will require a significant update in just five years. If you aim to extend your life you must perform a constant analysis of scientific research in this area. Currently many new methods are appearing every day, e.g. ways of lengthening telomeres and gene therapy. Additionally, the older you are the riskier new methods you should try.

The map of ideas

In fact, the map contains a systemized analysis of ideas, which can lead to life extension, but not a bunch of well-proven tips. In an ideal situation such a map should contain links to research about all the listed items, as well as an evaluation of their real effects, so any help on improving the map will be welcomed.

This map (like all my other maps) is intended to help you navigate through the world of ideas. In this case it includes life extension ideas. The map is open to new ideas and will be updated as they will be found.

Moreover, one single idea may become a salvation for a person, e.g. eradicating a certain chronic disease. Of course, no single person can complete all of the ideas and suggestions in this map or indeed in any other list. I'm pretty sure that people will not be able to implement more than one advice per month – and I'm no exception.

My approach: I drink alcohol on really rare occasions, I don't smoke (but sometimes I use nicotine wrapping with nootropic objectives), I sleep a lot, I try to walk at least 4 km every day, I avoid risky activities and I always fasten my seatbelt.

I also invest a lot of effort in preventing my brain from aging and in combating depression. (I will provide a map about depression and nootropics later).

The pdf of the map is here, and jpg is below.

alternative here: https://www.scribd.c...e-Extension-Map

 

lifeexteng.jpg

 

 

 


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#2 Danail Bulgaria

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Posted 23 October 2015 - 03:45 PM

This map is very nice :)

 

I wonder where from can be purchased NGF and BDNF.

 

Plus are they safe? I mean are they cappable of producing tumors :}



#3 turchin

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Posted 23 October 2015 - 05:53 PM

While some people are buying NGF in China (resveratrol guy), I would not do it until I see more tests on other people ))) and I prefer to stick to more proved and save NGF stimulators like Lion Mane, blueberry, acetyl carnitine  - see more in Brain health subforum here about NGF



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#4 pleiotropic

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Posted 24 October 2015 - 08:50 AM

Hmm.... why is donating to SENS absent from this chart?  :laugh:

 


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#5 turchin

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Posted 24 October 2015 - 10:37 AM

Hmm.... why is donating to SENS absent from this chart?  :laugh:

 

All social activity is not presented in this chart, because it is quite complex thing which require its own chart. 

This chart is only about personal methods. But donating SENS and other crowdfounding things is so important that it worth to mention anyway. 



#6 Danail Bulgaria

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Posted 24 October 2015 - 06:19 PM

While some people are buying NGF in China (resveratrol guy), I would not do it until I see more tests on other people ))) and I prefer to stick to more proved and save NGF stimulators like Lion Mane, blueberry, acetyl carnitine  - see more in Brain health subforum here about NGF

 

I am sure, that there will be volunteers to test the NGF in a study for people with early signs of senile dementia. There are many people, who would preffer to have mental ability and to live less, that to live longer without a brain, not knowing who they are, and shiting themselves every day infrontof their children. Many people with early stages of senile dementia would take the risk of duying, for testing this thing on themselves. I mean some of these people prefer eutanasia than the perspective of loosing their brain. Why not someone give the idea for testing this NGF as a drug. Droping eye drops every day is nothing complicated. If it ensures your straight thinking brain until the age of 100, then it is superb.



#7 turchin

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Posted 24 October 2015 - 09:10 PM

If I were on borderline demetia I would try NGF, but now I would wait couple of years. But I tried NSI-189 which is experimental drug connected with NGF last year. Results were moderetely positive, but in conclusive. I made several important decesions which I was not able to do before.

 

While some people are buying NGF in China (resveratrol guy), I would not do it until I see more tests on other people ))) and I prefer to stick to more proved and save NGF stimulators like Lion Mane, blueberry, acetyl carnitine  - see more in Brain health subforum here about NGF

 

I am sure, that there will be volunteers to test the NGF in a study for people with early signs of senile dementia. There are many people, who would preffer to have mental ability and to live less, that to live longer without a brain, not knowing who they are, and shiting themselves every day infrontof their children. Many people with early stages of senile dementia would take the risk of duying, for testing this thing on themselves. I mean some of these people prefer eutanasia than the perspective of loosing their brain. Why not someone give the idea for testing this NGF as a drug. Droping eye drops every day is nothing complicated. If it ensures your straight thinking brain until the age of 100, then it is superb.

 

 



#8 Danail Bulgaria

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Posted 25 October 2015 - 07:16 AM

Offer this to competent people from your country. There are many doctors, who want do science for different reasons, but have no ideas. This is a superb idea. Usually senile dementia is being monitored and treated from psychiatrists, neurologists and gerontologists. Simply go to the nearest university department of neurology and suggest them to start the research. They should have many demented patients. You may hit the bulls eye with your plan to wait and see the results before starting to apply it to yourself.

 

By the way, what is your opinion on the Lion Mane, blueberry, and the acetyl carnitine. Taking them for brain regeneration sounds too good to be true.



#9 turchin

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Posted 25 October 2015 - 08:43 AM

I started memantine 3 months ago in very small doses of 2.5 mg and it helped to end for now my years long depression. One of mechanisms of its action is BDNF promotion.

That is my biggest success story so far.

I am also added Lion mane two weeks ago, feel good, but don't see any extreme results. Anyway brain regeneration is long term project. 

I tried to eat real blue berries (that is ones from north) as often as I can.



#10 Aardvark202

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Posted 18 December 2015 - 02:51 AM

Doctors have tried direct injection of NGF for nerve regeneration before, but it happens to be a direct activator of pain neurons so suffice to say the patients all dropped out pretty quickly.  It couldn't be taken orally because it's a peptide.

 

Nice chart btw.  I know I'm a little late to this topic, but do you have links to studies/articles for Enalapril and aging?


Edited by McSchwangstasis, 18 December 2015 - 02:52 AM.






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