As far as protecting the stomach goes, PPC / polyenylphosphatidylcholine (PhosChol) has shown remarkable properties.
http://www.lifeexten...ort/Page-01?p=1
My girlfriend gets cluster headaches and must take NSAID's for them but they were wrecking her stomach. She swears by PhosChol now.
As far as lower GI issues go, we've both been taking Culturelle (lactobacillus rhamnosus), which has been shown to survive stomach acids and effectively colonize in the colon better than many other strains.
Not sure if the probiotic will help with supplement irritation in the colon, but PPC / PhosChol will give you a bullet proof stomach better than anything I know.
"A study on experimentally induced gastric ulcers in rats (Dunjic BS, et al., 1993) showed that mucosal lesions were significantly reduced by a single dose of PPC given before or after the injury factor, which in this study was ethanol or an NSAID.
A recent clinical trial compared the GI effects of aspirin to those of aspirin complexed with PPC (Anand BS et al., 1999). Sixteen healthy subjects were given either ten doses of aspirin or ten doses of the aspirin/PPC complex over a 72 hour period. After a "washout" period, subjects were switched over to the other medication for a 72 hour period.
Researchers counted the number of gastroduodenal erosions in each subject. Those taking aspirin had an average of 8.75 erosions, while those taking the aspirin/PPC complex averaged only 2.81 erosions. The protective effect of PPC was most apparent in those who were most susceptible to aspirin injury, and did not interfere with the therapeutic activity of the aspirin."
Edited by synesthesia, 31 October 2015 - 04:04 PM.