Metadoxine ER
- Mechanism: 5-HT2B selective agonist / GABA modulator
- Company: Alcobra Pharma
- Status: Phase III clinical trials
Metadoxine is a drug primarily used to treat alcohol intoxication, but has also demonstrated efficacy for the treatment of ADHD. Alcobra Pharma is currently conducting a Phase III clinical trial to test the efficacy of Metadoxine ER (extended-release) for the treatment of adult ADHD. The drug is unique to other ADHD medications in that it is comprised of an ion pair salt of Pyridoxine (Vitamin B6) and L-Pyroglutamate.
The drug functions as a 5-HT2B selective agonist and has a high affinity for the GABA transporter, thereby preventing GABA degradation. Its mechanism of action is novel in that it doesn’t significantly alter monoamines (serotonin, norepinephrine, and dopamine). It solely acts on the 5-HT2B receptor as an agonist, and modulates GABA.
In animal research, administration of Metadoxine resulted in enhancement of cognitive function. The extended-release Metadoxine developed by Alcobra will combine immediate-release and slow release formulas within one pill. Evidence from clinical trials suggest that Metadoxine is effective for the treatment of adult ADHD, and perhaps most effective for those with the inattentive ADHD subtype.
The two components of this drug are Pyridoxine (Vitamin B6) and L-Pyroglutamate put into an extended release formulation. Both of these components are basically nutritional supplements and you can find them online fairly cheaply.
Can anyone explain if combining these two drugs is necessary for the ADHD treatment effects? Would supplementing these components in a non-extended release work for ADHD? Could I try taking just L-Pyroglutamate by itself and expect the same results? etc?
