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Constant Heavy Drunk/Drugged/Sedated Brain with Dimmed vision and Anhedonia

brainfog dimmed vision anhedonia

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#61 Sephrioth

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Posted 04 February 2018 - 06:19 AM

I just wanted to update this thread. I used low dose Selegiline for 4-6 months and it worked a bit for Anhedonia, but did nothing for my other symptoms. It still works a bit, but less than before.

 

My main symptoms are just as bad if not worse (Brainfog/Yellowish dimmed, slowed down vison/drunk/drugged feeling/ Feeling like I have a fever-brain without the fever). "Brain in 'sick mode' feeling (like when you have the flu).

 

I still believe these symptoms could be caused by NMDA and maybe (GABA) systems (since the only thing that ever really decreased those symptoms was Pregnenolone (a NMDA agonist and GABA Antagonist). But it had many side effects and lost its effectiveness. I haven't used it in the last 5 years.

 


Edited by Sephrioth, 04 February 2018 - 06:20 AM.


#62 muntjac

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Posted 09 February 2018 - 07:46 PM

Have you looked into Bartonella? Both it and Lyme can affect vision. I suggest you visit a Lyme board, those infections can be very difficult to treat and most physicians know less about them than the general public.



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#63 kanekiken

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Posted 11 February 2018 - 03:14 PM

This is me pretty much, except for the vision part. My vision just feels off and I feel zoned out. Like the vision you get after three shots of vodka. Hard to explain, some might call it blurry but not really.. No yellow hue though. It feels terrible. Like my brain is too slow to register what I see, which in turn makes it impossible to concentrate and when it's really bad I just want to lay down and do nothing.



#64 Sephrioth

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Posted 11 February 2018 - 06:27 PM

My vision is not really yellow, at least not like a yellow filter or something. I can see all the colors, but the contrast is strange, everything looks 'sickly' especially at night everything looks lid by candlelight. It's a bit like walking from sunlight into a dark room, but also not exactly. Everything looks off, but now like an edited photo.

 

It resembles more the vision when you are very ill, with a high fever and your brain is not working properly. I remember when I was a child and I had the flue, a high fever and unrelenting and intolerable nausea because of Cyclic Vomiting Syndrome, I had almost no sleep for days because I was throwing up every 3-5 minutes. And that is sort of how my vision looks, but far worse. I can't tolerate low lighting situations, everything seems off, sort of far away, slowed down, like I am on a heavy sedative, but also darker, wrong contrast but not really like what you would get when you would post-process a video with filters or something.

 

My brain feels ill like it's stuck in constant 'sick mode'. I read that your brain has a 'mode' when you are ill. I think I may have some higher brain inflammation, that sometimes gets worse and I feel even worse. But of course, I can't be sure about that. But I also suspect diffuse brain damage and GABA (too high) NMDAR (too low), Dopamine and Norephedrine involvement.

 

This is 24/7 every day. It varies between 65% (sedated ill/drugged/drunk) on a sporadic 'good' day, the average is 70-75% (sedated/drunk/drugged), and at worse almost totally unbearable 90-95% drugged/drunk where I can literally do nothing and every second is agony).



#65 missmilla

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Posted 03 October 2019 - 10:01 PM

Thank you so much for posting this. In >15 years it is the only description I have found that matches my own experience with dimmed, yellowish (candle-like) vision with heavy drugged sedation. I too found the description from the chap on phoenixrising but that does not match so closely. Our histories are not identical but the current experience sounds very much alike, except that for me the anhedonia is less severe while the fatigue (which is distinct from the sedation) is so extreme mentally and physically that I am unable to function at even a basic level - I can't work, read books, watch films, stand or sit up for long (or often at all), go out, see other people, or generally do the things I want to do. But I do still want to do those things, and identify entirely with your certainty that it is not depression or anxiety (quite the opposite) and that it is neurological rather than psychological. I have also come to much the same conclusions about GABA and NMDA.

 

I haven't found anything that helps the sedation but would like to ask: have you by any chance had your genome sequenced? I have recently been analysing my own whole genome data and found a rare variant that may be relevant. It affects a gene that controls the synthesis of GABAergic neurosteroids but is unfortunately not yet well researched, especially in terms of disease association. It would be interesting to see if you have anything similar. Please feel free to PM me if you'd like to discuss it at all.

 

 

 

 



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#66 StevesPetMacaque

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Posted 04 October 2019 - 03:20 AM

I don't know how active the OP is any more, but clearly, the early-life head trauma left the brain vulnerable to later injury, despite the outward appearance of health.

 

Fortunately, even though they are now dysfunctional, many of the cells are probably salvageable.

 

Very, very high dose (500-1000 mg or more per day) of thiamine, particularly allithiamine or perhaps sulbutiamine (but not benfotiamine, which doesn't cross the BBB AFAIK), can help rescue the mitochondria. B1 is in your stack already, but if you haven't tried these other forms, I would suggest them. I sometimes find that my body's need for magnesium increases when I take high dose B1.

 

Also, you can use high dose niacinamide to help renew and repair your mitochondria; details in this thread.

 

Neither of these methods is likely to be a silver bullet, but you may find enough functional benefit to move on to the next step.


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