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Plant and food chemicals may help treat cancers

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#1 Kalliste

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Posted 20 November 2015 - 12:01 PM


Nice to see them finally coming around to this. Most oncology related reserachers are too busy investigating money making compounds it seems. Note the part bolded by me.

 

Quote
Plant and food chemicals may help treat cancers November 18, 2015

Combinations of a significant number of non-toxic chemicals, many of which can be found in plants and foods, may help treat advanced and untreatable cancers, according to new research from a global task force.

The task force of 180 scientists from around the world includes University of Auckland Professor of Cancer Nutrition Dr Lynn Ferguson who says the research also suggests that non-toxic doses of plant and food chemicals may address the problem of cancer relapse. Professor Ferguson also led one of the individual working teams, focussing on genomic instability.

The research paper synthesis was published today (18 November), along with the supporting work from each of the teams, in a special issue of Elsevier's Seminars in Cancer Biology. In light of this evidence, the task force is calling for an immediate increase in support for research on mixtures of chemicals that can reach a broad-spectrum of therapeutic targets.

"While current therapies have achieved modest successes in some cancers, significant problems remain with most of our approaches to treatment," says Dr Ferguson. "In particular, many newer targeted therapies are extremely expensive, highly toxic and not effective for rare types of cancer and advanced cancers."

"Even when they appear to work, a significant percentage of patients will experience a relapse after only a few months," she says. "Typically advanced cancers are untreatable and relapses occur when small sub-populations of mutated cells become resistant to therapy. Doctors who try to address this problem with combinations of therapies find that therapeutic toxicity typically limits their ability to stop many cancers."

To tackle this problem, the task force of 180 scientists from prominent institutions in 22 countries was assembled by a Canadian NGO called "Getting to Know Cancer".

Interdisciplinary teams were formed and they nominated a series of high-priority molecular targets (74 in total) that could be reached with chemicals to improve patient outcomes.

Corresponding low-toxicity chemical approaches were then recommended as potential candidates for a mixture of chemicals that could reach a broad-spectrum of priority targets in most cancer types.

"While some chemicals, such as metformin and dichloroacetate, are older drugs that have potential due to their low toxicity, many of the chemicals that were selected, such as resveratrol in grapes, genistein in soy, curcumin and others, can be extracted from plants and foods," says a scientist from Illinois Dr Keith Block, the Medical and Scientific Director of the Block Centre for Integrative Cancer Treatment.

"Although most have been studied for individual anti-cancer effects, there has been almost no research done on substantial combinations of these chemicals," he says. "This was the first time that teams of researchers with such a wide range of expertise have ever been assembled to address the complex problem of relapse."

"The task force teams have emerged believing that carefully designed combinations of non-toxic chemicals can be developed that will maximize our chances of arresting most cancers", says Dr Block who is the lead author of this group.

There are still many unanswered questions so animal trials are now needed to advance this approach before human trials are possible.

"But this is an area that merits considerable attention," says Dr Dean Felsher, a project contributor from the Department of Medicine at Stanford University. "Our approaches to therapy are improving, but we need a breakthrough that can help us address the problem of relapse, and this is a new, paradigm-changing approach that might just give us a chance."

The taskforce also wanted to produce an approach to therapy that would have the potential to be very low cost, because many of the latest cancer therapies are deemed unaffordable in low-to-middle income countries.

Accordingly, the task force has laid the groundwork for a solution that should be both inexpensive and effective in making this novel approach available to people who are suffering from cancer throughout the world.

Explore further: Global taskforce calls for research into how everyday chemicals in our environment cause cancer

More information: Keith I. Block et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment, Seminars in Cancer Biology (2015). DOI: 10.1016/j.semcancer.2015.09.007

Provided by: University of Auckland

http://medicalxpress...ls-cancers.html


Edited by Cosmicalstorm, 20 November 2015 - 12:02 PM.


#2 xEva

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Posted 20 November 2015 - 10:46 PM

Explore further: Global taskforce calls for research into how everyday chemicals in our environment cause cancer

 

Sorta fight fire with fire  :laugh: 
 

The taskforce also wanted to produce an approach to therapy that would have the potential to be very low cost... and... has laid the groundwork for a solution that should be both inexpensive and effective ...


Heard this many times. It has not happen and will never happen, the opposition will come from both ends. I can already hear the patients bitching that their always oppressive government just wanna save money and treat them with paint thinners and such instead of real medicine. Doctors will not be trained in this, 'cause the only training they get is through pharma who makes them dispensers of their pricey pills.
 



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#3 Kalliste

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Posted 21 November 2015 - 12:36 AM

Cancer is an evolutionary force that will outsmart almost everything. I think this kind of combination treatment (fasting + meditation + phytochemical combo + chemo/radiation) might help some, maybe many, sufferers. Not cure them all. Since these things are readily available and cheap they shoukd be used more until we can get nanosurgery.

#4 HighDesertWizard

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Posted 21 November 2015 - 02:27 AM

I've believed that healthful transformation is possible with substances derived from plants a good while, especially since I once accidently cured my carpal tunnel syndrome... I described it in the following post a while back...

 

I believe I once triggered significant and positive Epigenetic change in myself by accident...

 

For years, I wondered about what had happened to me. And then, once I learned a bit about the science of Epigenetics, I finally had an Explanation of what Might have occurred. I'm not a scientist but, because of my experience, I am interested in Conscious and Deliberate attempts to Trigger Positive Epigenetic Change...

 

Around about 2006, my early stage Carpal Tunnel Syndrome (CTS) symptoms began to worsen. I purchased wrist braces for sleep to deal with waking up with both wrists numb until I shook my hands for about a minute to get feeling back. CTS runs in my immediate family: my father had CTS surgery on one wrist and a sister on both wrists.

 

I had been doing do-it-yourself, n=1, experiments on myself for a decade. At that time, I decided to mega-dose on an anti-inflammatory herb called Boswellia (and specifically the AKBA, 5-Loxin, formulation), 2 grams a day for a reason unrelated to the CTS.

 

If you look at this closely, you'll quickly realize that a 2g/day dose of Boswellia [AKBA] is a big dose. Was I worried about toxicity? No, I'm happy to explain why I wasn't later. I made my own capsules from a 5-Loxin powder source I found on the 'net.

 

Within one week of my beginning this experiment, my CTS symptoms vanished. I mean they Vanished. It was amazing. I stopped the Boswellia [AKBA] dosing and the symptoms returned within about a week and I decided to try it again.

 

I did that same dose of Boswellia [AKBA]--5-Loxin specifically--again. My CTS symptoms vanished a second time after about a week. I continued that dose for one month and then stopped completely.

 

My CTS symptoms were gone and have never returned.

What's the Explanation for what happened to me? Like I mentioned above, I believe the best explanation is that I triggered Positive Epigenetic Change...

  • There are several studies that show Boswellia can trigger Epigenetic Change and/or Gene Expression of ProInflammatory Genes. 
  • ​There are several studies that show MPPs (Matrix Metalloproteinases) are implicated in CTS.
  • There are several studies that show Boswellia can have a Positive Impact on MMP Expression.

I'll be happy to provide links to these studies as desired/needed. In the meantime, I wanted to share my story and get feedback about it.

 

Thoughts?

 

Edited by HighDesertWizard, 21 November 2015 - 02:28 AM.

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#5 niner

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Posted 22 November 2015 - 03:20 AM

 

The task force of 180 scientists from around the world

 

 

I hope a couple of them were pharmacologists, because phytochemicals tend to have abysmal pharmacokinetics.  They work great in vitro, not so good in vivo.  Advanced formulation can help, but may increase cost.







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