"And in terms of aging, he found similar reduction of BMAL1 in chondrocytes, which coincided with the reduced 'amplitude' of the body clock (up to 40% weaker in older mice), supporting the theory that aging, at least partially through dysregulation of the chondrocyte clocks, is a major risk factor for osteoarthritis."
http://www.medicalne...ases/304075.php
and here:
"The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity"
http://www.jci.org/articles/view/82755
