I'm sure someone has posted this but just in case:
http://www.huffingto..._n_5329910.html
"The researchers tested their idea on nematodes, millimeter-long worms commonly used in longevity studies. They hit the jackpot with the first molecule they tried, α-ketoglutarate (α-KG), an intermediate in a metabolic cycle that helps a cell extract energy from food. When the researchers added the compound to the worms' culture dishes, the animals survived up to 70% longer than normal, the team reports online today in Nature. The animals carried about 50% more α-KG in their cells than did control worms. Like calorie restriction, the extra α-KG postponed the worms’ physical deterioration."