10 replies to this topic

[sinker123]

So Phenibut came into my life earlier this year and it absolutely changed my existence for the better. For once in my life I didn't feel depressed and could get up in the morning and face the day.... Long story short  -  I was prescribed a pain killer and took it as prescribed. When it was discontinued I had the worst 1.5 weeks of my life. I used the phenibut to alter the effects and I would give anything to go back in time bc it's like I blew through a gasket andf there is no going back.

 

I know that the party is over bc - I no longer even feel the withdrawal effects  when I stop taking it. I noticed that I would get a benzo like withdrawal when I didn't take it....now - nothing.....its completely lost its affect on me

 

I believe I read that upregulating dopamine receptors was the goal. I have no idea how to do that. I don't typically use my stimulant medication but was wondering if I used it again would my dopamine be upregulated and thus a phenibut resurgence?

 

 

I would really appreciate some help here

[sinker123]

I am going to get a prescription for baclofen to see if that may be a better long term solution

[AgeofVergo]

What dosage of phenibut did you take/day? did you dose every day? did you cycle?

 

Switch to Kratom, but be warned, you have to cycle this. If you're an addictive personality stick to aniracetam, the slow but sure method.

 

To fixing your dopamine receptors, you will need Sulbutiamine, which also needs to be cycled. Give it a good long brake and I'm sure you'll get your sensitivity back, but just don't make the same mistake. And even if that fails there are alternative noots.  

[sinker123]

I tried Sulbutiamine before and didn't have any beneficial effects.... Will this upregulate dopamine?

 

I got a script of Baclofen last night.... My doctor is amazing and lets you try things you want to try..... I noticed that today it did in fact help with morning anxiety. hat 

 

I read somewhere that there are 4 gaba b receptors and phenibut and baclofen each working on different gabab receptors...is that true... My hope is baclofen will add as much upside but will no have the tolerance issue and can start the gaba b process over.

 

[AgeofVergo]

I suspect with Sulbutiamine you need to commit to a slow approach, don't mega dose it, I've had a very crap experience from taking too much. So don't expect to get back to base line over night. Commit to very small doses over 2 or more months. 

 

Check you this reddit thread for dopamine upregulation 

https://www.reddit.c...mine_receptors/

[Omega 3 Snake Oil]

I used phenibut once per week for about a year to good effect (800-1200 mg). Recently it's stopped working, like it seemed to stop overnight.

A few months ago I added modafinil 100 mg 2X per week, which worked great at first then stopped working as well.

Have been on selegiline, 2.5 then 1.25 per day the entire time (had been as high as 10 mg a day before that, prescribed for muscle twitching).

Have also been using bee venom to treat Lyme disease. I'm worried I messed up my HPA axis as I've had symptoms of adrenal insufficiency the past few weeks. Have stopped bv and modafinil. Tapering off selegiline.

I'm wondering if any of this is connected..

[Introspecta]

 The action of phenibut doesn't work straight through dopamine. It works through Gaba b agonism which when it wears off causes a spike in PEA which in turn stimulates dopamine. Its not a direct D2 effect.

 

Your better off just taking a long break and then going back and getting some quality phenibut not the bulk crap that is being sold.

[sativa]

Any stimulant medication will likely further diminish dopamine (due to agonism of dopamine receptors I presume).

The following will help to stabalise dopamine:

Uridine
N-Acetylcysteine
Jiaogulan

Theanine will reverse the down regulation caused by phenibut and should provide the same benefits:

Theanine gives the same effect as phenibut, but instead of through agonism it's through antagonism so it can be taken every day without tolerance.

Theanine blocks mGlu1, which is coupled with GABA-B. So by antagonizing and upregulating mGlu1, it upregulates GABA-B. I didn't find the paper that proved this until after I took theanine and noticed its effects for myself.

http://www.ncbi.nlm....les/PMC2726695/

The GABA-B upregulation happens after theanine wears off.

Jiaogulan (Gynostemma pentaphyllum) Has a restorative effect on dopaminergic systems after chronic stress and 6-OHDA-induced neurotoxicity. Unique in its proven abilities to promote healing of the dopaminergic system, rather than just prevent degredation.
http://www.ncbi.nlm....pubmed/20428081

N-acetyl-cysteine - Also regulates the dopaminergic system in a similar way to bacopa, although seemingly less effectively.
http://www.ncbi.nlm....pubmed/19277967

Edited by sativa, 30 January 2016 - 11:10 AM.

[contraband]

What's the evidence that phenibut HCl affects dopamine (just curious - not challenging anyone)? 

[sativa]

What's the evidence that phenibut HCl affects dopamine (just curious - not challenging anyone)?

Here is one study from a quick Google search, as you can see, GABA(B) is present on dopamine neurons. Phenibut is a GABA(B) agonist. There are likely other better papers showing this.

Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system


The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic dopamine system, which is inhibited by putative anti-craving compounds. Interestingly, different GABAB receptor agonists can exert similarly opposing effects on the reward pathway
...
In conclusion, our findings, extended to other GABAB receptor agonists, suggest that low-affinity compounds are more likely to cause activation of the mesolimbic dopamine system than high-affinity agonists, which at typical concentrations will inhibit the system.

Edited by sativa, 01 February 2016 - 10:49 PM.

[kurdishfella]

It could still be working you just got used to the effects. Some things work without you being able to tell much like nutrients. Or maybe you changed brand?