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[birthdaysuit]

Would peptides be elevated as a result of taking Rhodiola Rosea? Peptides being Arginine Vasopressin, implicated in anxiety and depression. Arginine Vasopressin stimulates cortisol release, even moreso than Corticotropin-Releasing Hormone. Neurotensin would be the other one, which appears to disincentivize d2 receptor effects as well as decrease dopamine concentration in Ventral Tegmental. Hence, potential side effects upon prolonged usage. 

 

However, altered PREP activity may be associated with ASD and various psychological diseases such as schizophrenia, mania and clinical depression. More recent studies have demonstrated that inhibition of the same enzyme actually results in alleviation of depressive symptoms.

 

I’ve recently bought Perfect Freeze dried Rhodiola Rosea and I want input on how I should be taking this adaptogen. I would like to work it in with my exercise regime and see if it helps fight fatigue and combat anxiety. I have taken it before, I’m just looking for the right dosage and the best way to take it.  

Edited by birthdaysuit, 01 February 2016 - 04:58 AM.

[birthdaysuit]

So generally speaking would Prolyl Endopeptidase Inhibition elevate Arginine-Vasopressin? I’m a little weary on taking Rhodiola Rosea again. I took it a year ago and my anxiety increased 10-fold on 400mg 3% Rosavins, so I stopped. A month later I took 200mg everyday for two weeks and felt pretty happy but upon cessation my anxiety increased.