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Thoughts on problems with my cognition

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#1 Qowpel

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Posted 06 February 2016 - 02:45 AM


So here it goes.

I have been a stand up comic for a while. I generally have a more alternative delivery and material than more mainstream observational comics. Example. I have a joke in which I am telling a story of how I hit a deer with my car. When it was sliding away on the road it ricochet off a curb and sort of settled like a coin. . . It landed on its back so. . . . Tails. . .

Anyway of course it won't sound very funny writing it here but I just wanted to give an idea of the connections my ADD gives me.

Anyway over the years I have constantly hit writers block and would like to share how and what affects the state of whether or not I have writers block. An example would be that when I drink caffeine I can really only stay on one topic in a very concentrated way meaning that it is even harder to create loose associations and connections with things then if I had not had any caffeine a.k.a. sober.

When I am fully sober I am better able to write but constantly have a writers block that lifts every twenty minutes or so when writing. However I have also noticed that when I am extremely sleep deprived I get this drowsy feeling but my creativity skyrockets in which I only have brain fog or lack of ID is roughly half of the time rather than every 20 minutes.

I also realized that drinking makes me more creative in that I get more ideas on the paper and sometimes create punchlines or premises that would take me five times as long to come up with if I was sober.

I have been reading that a parent Lee higher testosterone levels can hinder creativity and that higher estrogen levels may indeed increase creativity. I can say that as a five or six years ago when I had my testosterone levels checked which was at ages 18 and then 19 that my testosterone was roughly only levels that 35 to 40-year-old male would have.

On top of this when I am not consistently taking my 300 mg of extended release Wellbutrin that it is much harder for me to overcome my brain fog while writing an event my verbal fluency and short-lived phases of euphoria that I have one writing disappear if I am not taking the drug so I am wondering what district is doing to help my writing even though it does happen to hurt my short-term memory.


I am trying to figure out how I can listen this brain fog on a regular basis and how I can do this while maintaining my ADD related ways of connecting things loosely but fittingly. What do you all think

#2 Logic

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Posted 07 February 2016 - 11:28 PM

Hmmm...  Low dose Modafinil?

25mg is said to clear the fog and 'raise IQ' according to anecdotal reports.

http://www.longecity...560-modapharma/

 

Then there was a guy here who wrote prolifically in a crazy savant sort of way and was a real page turner on Piracetam, but he burnt himself out.
You have to take it easy and take co-cofactors like Cholin IIRC with it.

 

Use Googlesitesearch in the search dropdown menu (top right) to look him up.

 



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#3 ModaPharma

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Posted 09 February 2016 - 09:41 AM

Hmmm...  Low dose Modafinil?

25mg is said to clear the fog and 'raise IQ' according to anecdotal reports.

http://www.longecity...560-modapharma/

 

Then there was a guy here who wrote prolifically in a crazy savant sort of way and was a real page turner on Piracetam, but he burnt himself out.
You have to take it easy and take co-cofactors like Cholin IIRC with it.

 

Use Googlesitesearch in the search dropdown menu (top right) to look him up.

 

Hey thanks @Logic for letting people know of our sample offer. 

 

Just to let people know if they're interested in our sample thread.

 

 

 

All the best, 

MP Support


Edited by YOLF, 12 February 2016 - 04:16 AM.


#4 YOLF

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Posted 12 February 2016 - 04:12 AM

I'm calling BS on higher T limiting creativity... you need T to keep your brain sensitive to dopamine and more. Cat's Claw will increase fantasies and that comes from creativity depending on what you do with it. Cat's claw blocks Estrogen receptors and increases the relative amount of T and E that your brain is running on. Get the picture?I think someone is blowing smoke on your balls...

 

What you're not understanding is that higher dopamine will result in lower T b/c you'll use more imo. Dopamine drives T production, but we have limits to what we can make, esp. as we age. Manage your cholesterol if you want to improve your T and creativity. Maybe try an aromatase inhibitor it you're overweight. Get some exercise, Get your T to target levels for your age with rx interventions if necessary.



#5 Qowpel

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Posted 18 February 2016 - 06:35 AM

I'm calling BS on higher T limiting creativity... you need T to keep your brain sensitive to dopamine and more. Cat's Claw will increase fantasies and that comes from creativity depending on what you do with it. Cat's claw blocks Estrogen receptors and increases the relative amount of T and E that your brain is running on. Get the picture?I think someone is blowing smoke on your balls...

What you're not understanding is that higher dopamine will result in lower T b/c you'll use more imo. Dopamine drives T production, but we have limits to what we can make, esp. as we age. Manage your cholesterol if you want to improve your T and creativity. Maybe try an aromatase inhibitor it you're overweight. Get some exercise, Get your T to target levels for your age with rx interventions if necessary.


Hi there Yolf. I would like to thank you for your insight. I can say that I have started taking aromasin 2 mg daily and my creativity went up a modest amount for about a week but is now stable once again.

I also have tried no pelt sublingual 5 mg dose and got dizzy for a minute then had a weird drunk like feeling and perception in terms of vision.... Then my productivity shot up for thirty minutes and then I got sever brain fog and now 24 hours I am having very very bad writers block making me think that maybe noopept is bad for creativity in terms of loose associations. Hmm. I took it with 200 mg of choline as well.

Sure is hard getting that nootropic feeling I am after.... And I know the one that I am after because i have experienced it five times in a way that is always replicated when I do it. Basically anytime I have started Wellbutrin at 150 mg, the first week I get like two or three days in a row that we slightly euphoric and extremely creative. It's like ability in creativity has been squared... Then it goes away as my body adjusts. Does the same effect when I go and increase dose to 300 mg and whenever I stop for a few months and start doing that hundred fifty mg to three hundred mg pattern again...

Maybe I am onto something here. If Wellbutrin creates those conditions for a few days then i must figure out how to create that state on a regular basis. Can this be done? Also can I get a similar effect from nootropics?

#6 YOLF

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Posted 18 February 2016 - 01:16 PM

 

I'm calling BS on higher T limiting creativity... you need T to keep your brain sensitive to dopamine and more. Cat's Claw will increase fantasies and that comes from creativity depending on what you do with it. Cat's claw blocks Estrogen receptors and increases the relative amount of T and E that your brain is running on. Get the picture?I think someone is blowing smoke on your balls...

What you're not understanding is that higher dopamine will result in lower T b/c you'll use more imo. Dopamine drives T production, but we have limits to what we can make, esp. as we age. Manage your cholesterol if you want to improve your T and creativity. Maybe try an aromatase inhibitor it you're overweight. Get some exercise, Get your T to target levels for your age with rx interventions if necessary.


Hi there Yolf. I would like to thank you for your insight. I can say that I have started taking aromasin 2 mg daily and my creativity went up a modest amount for about a week but is now stable once again.

I also have tried no pelt sublingual 5 mg dose and got dizzy for a minute then had a weird drunk like feeling and perception in terms of vision.... Then my productivity shot up for thirty minutes and then I got sever brain fog and now 24 hours I am having very very bad writers block making me think that maybe noopept is bad for creativity in terms of loose associations. Hmm. I took it with 200 mg of choline as well.

Sure is hard getting that nootropic feeling I am after.... And I know the one that I am after because i have experienced it five times in a way that is always replicated when I do it. Basically anytime I have started Wellbutrin at 150 mg, the first week I get like two or three days in a row that we slightly euphoric and extremely creative. It's like ability in creativity has been squared... Then it goes away as my body adjusts. Does the same effect when I go and increase dose to 300 mg and whenever I stop for a few months and start doing that hundred fifty mg to three hundred mg pattern again...

Maybe I am onto something here. If Wellbutrin creates those conditions for a few days then i must figure out how to create that state on a regular basis. Can this be done? Also can I get a similar effect from nootropics?

 

Well, half lives, sensitivity, and some other things can play a role. I experienced anxieties pretty bad along with unrequited emotional outlays or something like that when I took wellbutrin to quit smoking as a teen. 

 

So it sounds like you're experiencing a crest in levels and or sensitivity that may be difficult to replicate continuously. Noopept I've tried once with a different set of problems, though it is believed by many to be free of side effects. Noots aren't always well described in that way. Be careful. 

 

That said, if my anxieties were due to dopamine levels, the dopamine effect is stronger with higher T.



#7 Qowpel

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Posted 19 February 2016 - 12:24 AM

I'm calling BS on higher T limiting creativity... you need T to keep your brain sensitive to dopamine and more. Cat's Claw will increase fantasies and that comes from creativity depending on what you do with it. Cat's claw blocks Estrogen receptors and increases the relative amount of T and E that your brain is running on. Get the picture?I think someone is blowing smoke on your balls...

What you're not understanding is that higher dopamine will result in lower T b/c you'll use more imo. Dopamine drives T production, but we have limits to what we can make, esp. as we age. Manage your cholesterol if you want to improve your T and creativity. Maybe try an aromatase inhibitor it you're overweight. Get some exercise, Get your T to target levels for your age with rx interventions if necessary.

Hi there Yolf. I would like to thank you for your insight. I can say that I have started taking aromasin 2 mg daily and my creativity went up a modest amount for about a week but is now stable once again.

I also have tried no pelt sublingual 5 mg dose and got dizzy for a minute then had a weird drunk like feeling and perception in terms of vision.... Then my productivity shot up for thirty minutes and then I got sever brain fog and now 24 hours I am having very very bad writers block making me think that maybe noopept is bad for creativity in terms of loose associations. Hmm. I took it with 200 mg of choline as well.

Sure is hard getting that nootropic feeling I am after.... And I know the one that I am after because i have experienced it five times in a way that is always replicated when I do it. Basically anytime I have started Wellbutrin at 150 mg, the first week I get like two or three days in a row that we slightly euphoric and extremely creative. It's like ability in creativity has been squared... Then it goes away as my body adjusts. Does the same effect when I go and increase dose to 300 mg and whenever I stop for a few months and start doing that hundred fifty mg to three hundred mg pattern again...

Maybe I am onto something here. If Wellbutrin creates those conditions for a few days then i must figure out how to create that state on a regular basis. Can this be done? Also can I get a similar effect from nootropics?
Well, half lives, sensitivity, and some other things can play a role. I experienced anxieties pretty bad along with unrequited emotional outlays or something like that when I took wellbutrin to quit smoking as a teen.

So it sounds like you're experiencing a crest in levels and or sensitivity that may be difficult to replicate continuously. Noopept I've tried once with a different set of problems, though it is believed by many to be free of side effects. Noots aren't always well described in that way. Be careful.

That said, if my anxieties were due to dopamine levels, the dopamine effect is stronger with higher T.


So do you think noopept would be useless in my goals? Also do you think piracetam would help? Someone else mentioned it may. I take Wellbutrin which is anti choline do you think maybe choline is all I need? Do you have any idea how I could Maybe replicate the effect I got with Wellbutrin even if it's far fetched?

Edited by Qowpel, 19 February 2016 - 12:28 AM.


#8 medievil

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Posted 28 February 2016 - 11:05 PM

Stimulants make me creative, without them im not at all but that may be because the suffering i go trough then.



#9 YOLF

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Posted 01 March 2016 - 01:33 AM

Hmmm... have you gotten your 23andme genotype yet? I think that could really help to give us more than just a guess at what is going on. I wasn't aware that Wellbutrin was an anticholinergic... But if it's cutting down your choline levels substantially and maybe cholesterol levels and that could be lowering your sex hormones but leaving you with a higher differential of T to E? So you then benefit from the improved profile albeit lower over all levels, but then your sex hormones go subcritical and can't sustain your brain function? I feel like I'm out of my element on this one tbh. MAYBE someone who is more familiar with Wellbutrin/Zyban can give a more solid opinion.

 

But you could test it (nothing happens in isolation though) by cutting your Wellbutrin dose after the first few days to see if effects remain, though you did say that it happens again when you up the dose, but it could be moderated by dose and receptivity. I'm thinkin the added dose may have less to do 

 

Anyways, I'm wondering if you're not experiencing some kind of mania or serotonin syndrome or toxicity. I'm wondering if you're having any side effects from this and whether they're dangerous in the long term. 

 

I have to restart my comp RIGHT NOW. If I forget to come back and complete my thought or correct them let me know... I'm reading up on Wellbutrin.

 



#10 YOLF

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Posted 03 March 2016 - 11:40 PM

I'm calling BS on higher T limiting creativity... you need T to keep your brain sensitive to dopamine and more. Cat's Claw will increase fantasies and that comes from creativity depending on what you do with it. Cat's claw blocks Estrogen receptors and increases the relative amount of T and E that your brain is running on. Get the picture?I think someone is blowing smoke on your balls...

 

What you're not understanding is that higher dopamine will result in lower T b/c you'll use more imo. Dopamine drives T production, but we have limits to what we can make, esp. as we age. Manage your cholesterol if you want to improve your T and creativity. Maybe try an aromatase inhibitor it you're overweight. Get some exercise, Get your T to target levels for your age with rx interventions if necessary.

I guess fantasies is the wrong word, inspirations or fuel for such is more descriptive. I guess I'd see T's relative ratio as being a cofactor for many creative things. It's actually very soothing and lets you think at higher levels without stress and leaves you more plastic.



#11 Sleepdealer

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Posted 04 March 2016 - 01:38 PM

I saw this article on Stanford Med a couple of months ago.

 

Researchers tie unexpected brain structures to creativity — and to stifling it

 

"Investigators at Stanford University have found a surprising link between creative problem-solving and heightened activity in the cerebellum, a structure located in the back of the brain and more typically thought of as the body’s movement-coordination center.

In designing the study, the researchers drew inspiration from the game Pictionary."

[...]

"When they emerged from the MRI chamber, subjects were asked to rate the words they’d been asked to draw for relative difficulty. Increasing subjective difficulty of drawing a word correlated with increased activity in the left prefrontal cortex, an executive-function center involved in attention and evaluation. But high creativity scores later assigned by the raters were associated with low activity in the executive-function center. Higher creativity scores were associated with higher activation in the cerebellum."

[...]

“While greater effort to produce creative outcomes involves more activity of executive-control regions, you actually may have to reduce activity in those regions in order to achieve creative outcomes.”

 

The more you think about it the more you mess it up he says. Maybe this can add to the explanation why you can't work well on caffeine. I'm reading on Wikipedia that caffeine is an inhibitor of the Acetylcholinesterase. So, the levels of acetylcholine increase as follows which results in more activity in the frontal lobe, which is what you don't want according to the study. If this is true then it helps explain one aspect of why you become more creative on Wellbutrin. But I don't know how dopamine would affect you, since dopamine as far as I know also can enhance focus, especially for someone with ADD I suppose? Or is it ADHD?

 

As far as replicating the effects of Wellbutrin goes, I think you would have most luck with anticholinergic parkinson medicine. The only natural anticholinergic I know of is nutmeg, and you don't what to experiment with that, it can really impair you mentally, temporarily. There's lots of natural MAO-B inhibitors out there and you could probably get your hands on something like Atomoxetine for norepinephrine-uptake inhibition, if that is even needed for this effect.

 

Or you could do it the tDCS way, and do cathodal stimulation on the left dorsolateral prefrontal cortex to inhibit it and anodal stimulation over the right/left cerebellum, or any of the temporal lobes since they are involved in language and memory.


Edited by Sleepdealer, 04 March 2016 - 02:12 PM.


#12 medievil

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Posted 04 March 2016 - 06:45 PM

I would imagine that increased acetylcholine makes you more serieus and less creative, we see this in real life, to generalise highly educated ppl are generally more serieus, motivated in life, do more life motivated things etc, in contrast to more outgoing ppl that are more criminal, im really generalising here but for me personally stims turn me more in a criminal, liking dirty sex, risky things, serotonin regulates morality and in a club where everyone is on mdma your like on big family extremely friendly to eachother etc.

 

anyway acetylcholine lowers dopamine and visa versa, kinda explains the contrast btw boring academics and fun outgoing criminals, extremely generalising here dont get mad folks.

 

that said i think muscarinic antagonism could increase creativity, it increaes serenity in shizophrenia, i only notice anticholinergics in higher doses, like when i couldnt sleep on mdpv and i took loads of benadryl not knowing it mkes you trip, suddenly  small jesus statue turned hess cross around and started playing guature on it with the other jesus dancing, saw rats and cats all over my floor and a funny looking thing dancing on the top of mycupboard,my sa was gone but mdpv could have played a role and visisted a mate of me wo didnt understand a word i was saying.


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#13 YOLF

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Posted 04 March 2016 - 11:06 PM

I saw this article on Stanford Med a couple of months ago.

 

Researchers tie unexpected brain structures to creativity — and to stifling it

 

"Investigators at Stanford University have found a surprising link between creative problem-solving and heightened activity in the cerebellum, a structure located in the back of the brain and more typically thought of as the body’s movement-coordination center.

In designing the study, the researchers drew inspiration from the game Pictionary."

[...]

"When they emerged from the MRI chamber, subjects were asked to rate the words they’d been asked to draw for relative difficulty. Increasing subjective difficulty of drawing a word correlated with increased activity in the left prefrontal cortex, an executive-function center involved in attention and evaluation. But high creativity scores later assigned by the raters were associated with low activity in the executive-function center. Higher creativity scores were associated with higher activation in the cerebellum."

[...]

“While greater effort to produce creative outcomes involves more activity of executive-control regions, you actually may have to reduce activity in those regions in order to achieve creative outcomes.”

 

The more you think about it the more you mess it up he says. Maybe this can add to the explanation why you can't work well on caffeine. I'm reading on Wikipedia that caffeine is an inhibitor of the Acetylcholinesterase. So, the levels of acetylcholine increase as follows which results in more activity in the frontal lobe, which is what you don't want according to the study. If this is true then it helps explain one aspect of why you become more creative on Wellbutrin. But I don't know how dopamine would affect you, since dopamine as far as I know also can enhance focus, especially for someone with ADD I suppose? Or is it ADHD?

 

As far as replicating the effects of Wellbutrin goes, I think you would have most luck with anticholinergic parkinson medicine. The only natural anticholinergic I know of is nutmeg, and you don't what to experiment with that, it can really impair you mentally, temporarily. There's lots of natural MAO-B inhibitors out there and you could probably get your hands on something like Atomoxetine for norepinephrine-uptake inhibition, if that is even needed for this effect.

 

Or you could do it the tDCS way, and do cathodal stimulation on the left dorsolateral prefrontal cortex to inhibit it and anodal stimulation over the right/left cerebellum, or any of the temporal lobes since they are involved in language and memory.

Well if that's right, dancing could exercise your creativity. Maybe do some Tai Chi, Kabuki, Slow focus Shotokan, or the less muscle actuating form of Shotokan. Come to think of it, martial arts always helped me draw out my creativity. Better than any supplement even. At my creative height I was dancing wildly and terribly in private but writing some pretty awesome stuff, and tons of it. Though admittedly, it was lacking perspective. I think then that taking stuff that's good for collagen and limiting of AGE/glucosepane would be advantageous in preserving the ability to improve creativity in the long term. Think beta alanine, "chondroitin, glucosamine, MSM," RALA, ALCAR, GliSODin, glutathione, methylfolate, bromelain, "Ester-C, proline, lysine," boswelia extracts and those kinds of things. Then start movin!



#14 YOLF

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Posted 04 March 2016 - 11:20 PM

I would imagine that increased acetylcholine makes you more serieus and less creative, we see this in real life, to generalise highly educated ppl are generally more serieus, motivated in life, do more life motivated things etc, in contrast to more outgoing ppl that are more criminal, im really generalising here but for me personally stims turn me more in a criminal, liking dirty sex, risky things, serotonin regulates morality and in a club where everyone is on mdma your like on big family extremely friendly to eachother etc.

 

anyway acetylcholine lowers dopamine and visa versa, kinda explains the contrast btw boring academics and fun outgoing criminals, extremely generalising here dont get mad folks.

 

that said i think muscarinic antagonism could increase creativity, it increaes serenity in shizophrenia, i only notice anticholinergics in higher doses, like when i couldnt sleep on mdpv and i took loads of benadryl not knowing it mkes you trip, suddenly  small jesus statue turned hess cross around and started playing guature on it with the other jesus dancing, saw rats and cats all over my floor and a funny looking thing dancing on the top of mycupboard,my sa was gone but mdpv could have played a role and visisted a mate of me wo didnt understand a word i was saying.

 

Well Ritalin, and probably Adderall are known to reduce criminality substantially when used at suggested doses. If you're overdosing to get high there can be lack of control and loss of cognitive performance, but you'll feel really good. I know this from having to cut my dose in half (15mg works best for me). short term memory was 4 characters with 30mg and ~8-9 of my usual 11-14 on 20mg. I may give 7.5mg dosing a try sometime in the future. 

 

Oxytocin will always help you communicate better. So I think you need both to get the best results. T will help you use more of the stuff with less tension as a result.

 

So I guess dancing done where you believe you're performing or practicing for another is the idea.



#15 medievil

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Posted 05 March 2016 - 12:29 AM

Your talking about them reducing criminality in ADHD, but generally they make you make criminal. In my case higher doses dont cause a loss of cognition at all, the higher doses the more improved cognition.

 

10mg dexamphetamine is my optimal dose and also makes me more criminal ina way while reducing doing actual stupid criminal stuff and ending in prison.

 

 

What exactld do you mean T does? Also im not sure about oxytocin,i know it can help with empathy and trust 



#16 YOLF

  • Location:Delaware Delawhere, Delahere, Delathere!

Posted 05 March 2016 - 03:13 AM

Your talking about them reducing criminality in ADHD, but generally they make you make criminal. In my case higher doses dont cause a loss of cognition at all, the higher doses the more improved cognition.

 

10mg dexamphetamine is my optimal dose and also makes me more criminal ina way while reducing doing actual stupid criminal stuff and ending in prison.

 

 

What exactld do you mean T does? Also im not sure about oxytocin,i know it can help with empathy and trust 

Have you tested that? I know my hamburger is sensitive to everything, it may be my MTHFR mutation. How well do you methylate?

 

10mg is a pretty small dose for dexedrine isn't it? If it's making you more criminal, you should take less or not take it at all. Intelligence is order, though mania might have you thinking otherwise. Mania can be fine and dandy, lots of people have the genetics for it, but only a small fraction of them are diagnosable with bipolar. It's when there are problems in your life that cause it that you need to worry. What you don't know might hurt you or have you doing inappropriate things. if you're breaking with order, you're overdosing or empowered in ignorance to do things that you will regret when you are wise. PM me, I think we need to talk. 

 

Well oxytocin competes with dopamine for receptors and adds another layer of efficiency in a sense. T increases the number of receptors that you have. For instance, the higher my T levels, the more dopamine AND oxytocin I am able to use, thus I can be more creative.



#17 medievil

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Posted 05 March 2016 - 03:26 AM

I dont mean more criminal in the way you do, atleast on dex im just more confident and would do stuff i wouldnt do otherwise, perhaps because it abolises social anxiety, well 10mg is all i need for social anxiety, negatives in shizo and ADHD.

 

I dont really do anything criminal tough, i just get along with criminals, its not mania,its my personality, i am a criminal in a way, but without stims i did stuff that got me in prison,with i DONT, yet id talk with criminals and like to do stuff lol, its just me, but ive stayed on the good side of the law for 12 years or so.

 

without stims im too anxious too talk to criminals, with or without i dont see a issue with fraud or so, but with im less anxious to do stuff, its got nothing to do with mania, either way thx for offering help



#18 YOLF

  • Location:Delaware Delawhere, Delahere, Delathere!

Posted 05 March 2016 - 05:17 AM

So you're just less socially inhibited by it. Still, I would think that by hanging out with criminals, unless they are "decriminalized," that it's because you are taking a step down. You aren't confident enough or are too ashamed to try being with people who aren't criminals. You're not using the drug to improve your relationships, you're using them to feel better about being less. Give it up or start using it right.



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#19 medievil

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Posted 05 March 2016 - 07:41 AM

No mate, those arent my friends, i just get along with them, my friendship are ppl like me, ppl that used to be very shy but then dramatically changed and build confidence because of using mdma, including me, mdma gave me confidence but i was unable to use it without amphetamine, due to the chemically induced social anxiety.

 

I love and hang out with all sorts of ppl, shy, confident, acedemical, also at school when the confident bullys talked bad atbout the shy ppl i allways defended them.

o

All ppl are unique and i get along with everyone, i rather hang out with criminal acedemical ppl like my mates, atleast ppl that used to sell drugs or used drugs like me, those arent bad people, unlike ppl that steal of others, anuyway thats all past, when we were 19, now my mates have jobs and they truly are good people. 







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