2 replies to this topic

[Nondirective]

Hi, 

 

I have lurked here forever, and have always respected the minds here. This is my first post. 

 

I have tried tons of supplements and I'm trying to figure out now what all this evidence means. 

 

My symptoms were anxiety, brain fog, and feeling distant from others. Always felt different and away from the pack. Also a bit of paranoia - thinking ppl were out to get me, or didn't like me etc. 

 

It was a specific feeling, I was able to tell "bad days" by a physical feeling that always accompanied the same mental feelings. 

 

I think it might be serotonin, due to the following, but I am wondering at some of the curiosities. 

 

Sam-e changed some things - I felt more social and like others, yet the end result of the sam-e run was more  anxiety, so I quit that. 

 

Rhodiola was amazing for awhile, then it wore off. Rhodiola took away the restelssness, made me happy in whatever moment I was in, and more close to others, yet not the real warm closeness. 

 

Tryptophan (300mg AM, 300mg PM) was great, for about 2 weeks it changed my life. Mental fog went away. I wanted to be with others, and part of a community. I talked better, and I understood abstract concepts better. I felt that warm closeness with others. It was amazing. I was happy where I happened to be, doing what I happened to be doing. During week 3 it tapered off significantly. I am still not as irritable, but the effect was way worn. 

 

I still take it, maybe 500mg AM and 500mg PM now. 

When it was working better, the tryptophan reminded me of how I felt when I was young. More carefree, and happy. 

 

Side note, an amino acid blend (like a protein shake) will also make me feel calm and happy. They contain tryptophan as well, but you'd think that the other aminos would compete too much. 

 

So the questions are there - first, what do I do to increase serotonin like it was during the first two weeks of the tryptophan? 

 

Why would a protein shake come close to the tryptophan? 

 

Is this a digestive thing? Or just plain serotonin? 

 

As a side note, I take a pretty high dose inositol, 4G / day - and did all through this story. Once I tried to quit that and had such horrible (2-3) days that I started it again. Day one of quitting the inositol was awesome, days 2-3 sucked pretty bad. 

Just was hoping some of this might spark an idea / memory / experience.

 

I do take fish oil, vit D, vit c, zinc, magnesium glycinate and a quality B vit. 

 

 

Thanks! 

NonD

 

 

Edited by Nondirective, 11 February 2016 - 03:17 AM.

[birthdaysuit]

Do you take myo-inositol with Choline? I know taking it with choline can help to create acetylcholine as well as acts as a methyl doner. Taking high amounts of inostiol will increase phospholipids, like me this can lead brain fog and short-term memory issues. While I did not get brain fog during me sporadic usage I did when I started ingesting 3.5 grams morning and night. This significantly impaired my short term memory. I was unable to remember things I did 2 minutes ago, it was unbearable. I’d turn off a light and forget that I turned it off a few seconds later. Memory issues persisted after discontinuing. 

 
In the end it made me extremely agitated and callous. I was emotionally unbalanced and spacey and many people have had similar experiences. It’s bizarre because super loading inositol is required for any neurological effects. When I use it to super load sporadically, I did not experience any of the negative side effects, maybe it’s cumulative?  

 

Ensure proper Magnesium, Iron, Zinc, Potassium levels when supplementing with Inositol, the higher doses may require a supernormal need for them as well. Because it is anti-nutrient it can cause too much intracellular calcium which can be responsible for myoclonic jerks and muscle twitches. 

 

Inositol inhibits iron and zinc transport :

 
http://www.ncbi.nlm..../pubmed/8145081

 

 

myo-Inositol (1,2,3,4,5,6)hexakisphosphate (phytate), the major storage form of phosphorus in plants, has been considered to be an anti-nutrient due to its inhibitory effect on bioavailability of essential dietary minerals (Cheryan, 1980).

 
http://www.sciencedi...16816560000331X

 

 

 

 

http://www.ncbi.nlm....pubmed/24534010 

 

"The serum sodium/myo-inositol cotransporter gene is located on chromosome 21, and myo-inositol affects neuronal survival and function. Nevertheless, few in vivo studies have examined the role of myo-inositol in Down Syndrome."

 

CONCLUSIONS:

 
Adults with DS have a significantly increased brain concentration of myo-inositol, and this is associated with reduced cognitive ability. Future studies are required to relate myo-inositol concentration in people with DS to brain development and increased risk for developing Alzheimer disease.
http://www.ncbi.nlm....pubmed/16330724
 

 

 

Increased myo-inositol may represent tardive glial scarring in the prefrontal cortex, a notion supported by GFAP changes in this region after blast overexposure as well as clinical reports of increased myo-inositol in disorders of memory.

 
http://www.ncbi.nlm....pubmed/24534010

 

 

Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
 
Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors.

 

 

http://www.ncbi.nlm....pubmed/19499845

 

​Although this study doesn’t prove that it lowers serum testosterone in men, it sure seems to lower libido to considerable levels. 

Also, how is your diet??

Edited by birthdaysuit, 17 February 2016 - 08:35 PM.

[Nondirective]

Wow, thanks. Thats really good information. I have had this "feeling" that I should get off the inositol so I have been tapering it off slowly. I've been on it pretty high dose for a couple years now. I think I will continue to taper it down. 

 

How have the cognitive / memory issues been since you have (I assume) stopped the inositol? 

 

Very interesting, thanks for bringing this up. 

 

I wonder how it's affecting other things, like serotonin. 

 

I don't take it with choline. 

 

My diet is pretty good, I'm gluten free, but I don't eat nearly enough veggies.  

Thanks again!