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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

sarcopenia myostatin inhibition glucose metabolism improved insulin sensitivity

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#1 alc

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Posted 13 February 2016 - 03:07 PM


http://www.pnas.org/...50-a409cd310180



from the article:


"
Significance

Sarcopenia, or aging-associated muscle atrophy, increases the risk of falls and fractures and is associated with metabolic disease. Because skeletal muscle is a major contributor to glucose handling after a meal, sarcopenia has significant effects on whole-body glucose metabolism. Despite the high prevalence and potentially devastating consequences of sarcopenia, no effective therapies are available. Here, we show that treatment of mice with an anti-myostatin antibody for just 4 wk increased muscle mass and strength in both young and old mice. In old mice, this increase in muscle mass was accompanied by an improvement in muscle insulin sensitivity. These data provide support for myostatin inhibition as a potential therapeutic strategy for aging-associated sarcopenia and insulin resistance."



and a recent article on similar work:


Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

 

http://www.ncbi.nlm....les/PMC4600334/

 

from the article:

 

"Results

The human monoclonal antibody REGN1033 is a specific and potent myostatin antagonist. Chronic treatment of mice with REGN1033 increased muscle fiber size, muscle mass, and force production. REGN1033 prevented the loss of muscle mass induced by immobilization, glucocorticoid treatment, or hindlimb unweighting and increased the gain of muscle mass during recovery from pre-existing atrophy. In aged mice, REGN1033 increased muscle mass and strength and improved physical performance during treadmill exercise.

 

Conclusions

We show that specific myostatin antagonism with the human antibody REGN1033 enhanced muscle mass and function in young and aged mice and had beneficial effects in models of skeletal muscle atrophy."

 

 

 



#2 johnross47

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Posted 13 February 2016 - 04:50 PM

Sounds like something that I could use, being 69 years old. Are there potential downsides to myostatin inhibition? I run and work out but I've read elsewhere on Longecity that although it's possible to retain the bulk of muscle, the quality deteriorates. This sounds like the sort of treatment that a sensibly run health system would give to all older people, if there are no problems with it.


Edited by johnross47, 13 February 2016 - 04:53 PM.


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#3 alc

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Posted 16 February 2016 - 02:37 AM


 "I've read elsewhere on Longecity that although it's possible to retain the bulk of muscle, the quality deteriorates."

 

I would rather stay away from comments made by others, as there are lots of pooh-pooh-ers just making comments without reading the studies. Neither my comments or theirs should have any weight, but the only thing that really counts are studies or clinical trials results. 

 

In this area of muscle, seems like myostatin inhibitors are doing their job.

 

As an example look at:

 

http://milobiotechno...com/technology/

 

http://milobiotechno...atent-issuance/

 

http://milobiotechnology.com/pipeline/

 

 

I cannot say anything about Myos Corp., but they claim their Fortetropin® decreases Myostatin levels:

 

http://www.myoscorp....clinical-trials

 

http://www.myoscorp....clinical-trials

 

I hope somebody that is using their product could comment.



#4 zorba990

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Posted 16 February 2016 - 03:39 AM

"I've read elsewhere on Longecity that although it's possible to retain the bulk of muscle, the quality deteriorates."

I would rather stay away from comments made by others, as there are lots of pooh-pooh-ers just making comments without reading the studies. Neither my comments or theirs should have any weight, but the only thing that really counts are studies or clinical trials results.

In this area of muscle, seems like myostatin inhibitors are doing their job.

As an example look at:

http://milobiotechno...com/technology/

http://milobiotechno...atent-issuance/

http://milobiotechnology.com/pipeline/


I cannot say anything about Myos Corp., but they claim their Fortetropin® decreases Myostatin levels:

http://www.myoscorp....clinical-trials

http://www.myoscorp....clinical-trials

I hope somebody that is using their product could comment.

Here's another one reported to work (phosphatidic acid) from lecithin

http://forum.bodybui...php?t=164559501

More info

] Jordan M Joy, Ryan P Lowery, Joshua E Dudeck, Phosphatidic acid supplementation increases skeletal muscle hypertrophy and strength Journal of the International Society of Sports Nutrition 2013, 10(Suppl1):P13

http://herbnutrition...osphatidic-acid

Edited by zorba990, 16 February 2016 - 03:44 AM.


#5 corb

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Posted 16 February 2016 - 04:40 PM

Sounds like something that I could use, being 69 years old. Are there potential downsides to myostatin inhibition? I run and work out but I've read elsewhere on Longecity that although it's possible to retain the bulk of muscle, the quality deteriorates. This sounds like the sort of treatment that a sensibly run health system would give to all older people, if there are no problems with it.

 

It also increases life expectancy in mice by 15%. So it's safe (in mice).

And yeah sensibly run healthcare systems are trying to get this to their public.

I can't post links for some reason. There's an article about it from march 2015 by reason you can find it in the search maybe.



#6 niner

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Posted 16 February 2016 - 08:57 PM

I cannot say anything about Myos Corp., but they claim their Fortetropin® decreases Myostatin levels:

http://www.myoscorp....clinical-trials

http://www.myoscorp....clinical-trials

 

I hope somebody that is using their product could comment.

 

I bought 600 grams of their product (it goes by more than one name- Myo-X, MyoT12 are two) as an experiment.  Over the two months that I used it, I increased the weight and/or reps I could do in the gym to a significant degree.  At the end of the two month experiment I felt that I had improved muscle definition and that I had gained lean mass.  (I weighed more, but was not particularly more fat.)  I also noticed improvements in some tendinitis problems.  All that was a great result, but I couldn't rule out a placebo effect.  I might have been working harder because I knew that I had this "secret weapon" on board.

 

When I used up the 600g, I did not get more, rather I wanted to see if I would continue to improve, get worse, or what.  After a couple months, I had a sense that I was working hard in the gym and getting nowhere, and injuring myself in the process.  I just bought another 600g, so the next two months will be a further experiment. 

 

If you look on the web, there are a large number of reviews of this product among the body building community.  A lot of guys rave about it, and a lot of guys say it did nothing for them.  I can only surmise that it works for some and not others.  Age, initial condition, and concurrent supplementation and diet are probably factors.



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#7 alc

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Posted 17 February 2016 - 12:20 AM

 

 

I bought 600 grams of their product (it goes by more than one name- Myo-X, MyoT12 are two) as an experiment.  Over the two months that I used it, I increased the weight and/or reps I could do in the gym to a significant degree.  At the end of the two month experiment I felt that I had improved muscle definition and that I had gained lean mass.  (I weighed more, but was not particularly more fat.)  I also noticed improvements in some tendinitis problems.  All that was a great result, but I couldn't rule out a placebo effect.  I might have been working harder because I knew that I had this "secret weapon" on board.

 

When I used up the 600g, I did not get more, rather I wanted to see if I would continue to improve, get worse, or what.  After a couple months, I had a sense that I was working hard in the gym and getting nowhere, and injuring myself in the process.  I just bought another 600g, so the next two months will be a further experiment. 

 

If you look on the web, there are a large number of reviews of this product among the body building community.  A lot of guys rave about it, and a lot of guys say it did nothing for them.  I can only surmise that it works for some and not others.  Age, initial condition, and concurrent supplementation and diet are probably factors.

 

 

@ niner - thanks for telling us about your experience!


would be nice if we can test these substances via independent labs and publish the data.


maybe we can all donate for a study and ask Ichor Therapeutics, see if they are interested to run such study?


I saw that Myos Corp got an investment in December:


MYOS Corp (NASDAQ:MYOS) Stock Soars on Huge Investment of $30.375 Million


http://ir.net/news/s...30-375-million/


I hope could be a good sign to hint that their products work.


Thanks again for sharing your experience with us.

 

 

on a side note: placebo effect always fascinated me. if we can "hack" that path, we can learn lots of things.

 



#8 alc

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Posted 17 February 2016 - 12:22 AM

 

I can't post links for some reason. There's an article about it from march 2015 by reason you can find it in the search maybe.

 

 

@ corb - if you are on a windows machine, use a notepad or text editor to copy+paste the links into a new document, then copy and paste again in the messages here.

 

on a linux machine, you'll have less issues to clear the formatting.



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#9 ta5

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Posted 24 May 2016 - 01:59 AM

 

I cannot say anything about Myos Corp., but they claim their Fortetropin® decreases Myostatin levels:

http://www.myoscorp....clinical-trials

http://www.myoscorp....clinical-trials

 

I hope somebody that is using their product could comment.

 

I bought 600 grams of their product (it goes by more than one name- Myo-X, MyoT12 are two) as an experiment.  Over the two months that I used it, I increased the weight and/or reps I could do in the gym to a significant degree.  At the end of the two month experiment I felt that I had improved muscle definition and that I had gained lean mass.  (I weighed more, but was not particularly more fat.)  I also noticed improvements in some tendinitis problems.  All that was a great result, but I couldn't rule out a placebo effect.  I might have been working harder because I knew that I had this "secret weapon" on board.

 

When I used up the 600g, I did not get more, rather I wanted to see if I would continue to improve, get worse, or what.  After a couple months, I had a sense that I was working hard in the gym and getting nowhere, and injuring myself in the process.  I just bought another 600g, so the next two months will be a further experiment. 

 

If you look on the web, there are a large number of reviews of this product among the body building community.  A lot of guys rave about it, and a lot of guys say it did nothing for them.  I can only surmise that it works for some and not others.  Age, initial condition, and concurrent supplementation and diet are probably factors.

 

 

Any update Niner? It's been about 3 months. It looks like your first post about it was last October.







Also tagged with one or more of these keywords: sarcopenia, myostatin inhibition, glucose metabolism, improved insulin sensitivity

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