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Chloroquine for Cholesterol?

chloroquine hdl ldl cholesterol

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#1 Adam Karlovsky

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Posted 19 March 2016 - 10:11 AM


Another Interesting report from Suppversity:
 

Low dose of malaria drug chloroquine is associated with favourable effects on lipoprotein metabolism without significant influence on insulin resistance

A clinical trial of daily 250 mg of chloroquine diphosphate in patients with systemic lupus erythematosus showed significantly higher HDL cholesterol levels (27%) and lower levels of triglycerides (17%) in chloroquine-treated patients. Another study of high-dose chloroquine (250 mg four times daily for 3 days) in patients with diabetes showed a significant decrease in total cholesterol (8%) and LDL cholesterol (10%) levels. There was also a decrease in fasting plasma glucose levels (17%) and a corresponding increase in fasting plasma insulin levels (17%). These reductions were of a greater magnitude than those found in our study, due to the higher doses used. 

A longitudinal study of 24 patients with systemic lupus erythematosus on hydroxychloroquine reported a significant decrease in cholesterol (7.6%) and LDL cholesterol levels (13.7%) after 3 months of daily therapy. There was also a significant decrease in the frequency of dyslipidaemia (26% vs. 12.5%) in hydroxychloroquine-treated participants. Epidemiological studies have also shown a reduction of diabetes risk with hydroxychloroquine.

The effect of chloroquine in lipid and glucose parameters might be time-dependent, as already described in patients with systemic lupus erythematosus after long-term therapy. Therefore, chloroquine given for more than 12 weeks might result in more significant effects.

More recent data indicates that healthy participants treated with low-dose chloroquine (300mg) weekly had small, but significantly decreased triglycerides and cholesterol ratio, with lower LDL levels than controls. 

www.suppversity.com | Lee, L. S. U., et al. "Low‐dose chloroquine is associated with favourable effects on lipoprotein metabolism without significant influence on insulin resistance." Diabetic Medicine (2015).

 

 

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#2 Turnbuckle

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Posted 19 March 2016 - 12:34 PM

Three grams in three days and LDL down by 10%? A big dose for a small effect. The usual dose for malaria is 500 mg once a week.


  • Good Point x 1

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#3 Adam Karlovsky

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Posted 20 March 2016 - 01:47 AM

Chloroquine and it's metabolite have plenty of effects on the immune system, it's definitely not so simple. It is an immuno-suppressive, and as such should not be taken lightly as a cholesterol lowering drug. Having said that, it's an interesting enough compound I figured I'd post about it anyway, to give it a little more attention. It's been mentioned a few times at LongeCity before, but just in passing.



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#4 joelcairo

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Posted 20 March 2016 - 07:38 AM

Chloroquine is a significant inhibitor of autophagy. I think it may be the most powerful one known. This could have all kinds of implications for longterm systemic health.

 


  • Agree x 1





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