Life-Long Fish Oil Ingestion Reduces Mice’s Life Expectancy by 14% And the Reason is an Increase in Oxidation…
Scienists investigated the effects of dietary fish oil on lifespan and on lipid composition and oxidative stress in plasma and liver in SAMP8 mice. Male mice were fed a fish oil diet (5% fish oil and 5% safflower oil) or a safflower oil diet (10% safflower oil) from 12 wk of age.
The SAMP8 mice fed fish oil did not have a longer maximum lifespan and had a shorter average lifespan than mice fed safflower oil. To examine the mechanism underlying these results, the effects on oxidative stress of long-term ingestion of fish oil were also examined.
SAMP8 mice fed fish oil for 28 wk showed strong oxidative stress that caused hyperoxidation of membrane phospholipids and a diminished antioxidant defense system due to a decrease in tocopherol compared with mice fed safflower oil.
Doesn't appear to be rodent specific. An increase in oxidative damage due to fish oil in humans has been demonstrated in the 1990s, already
http://europepmc.org...act/med/1826131