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RELATED? Alzheimer's Amyloid & Pancreatic Amyloid/IAPP?

alzheimers diabetes amyloid plaque

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#1 Logjam

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Posted 18 April 2016 - 10:34 PM


I knew there was some sort of connection, whether it be because of BACE1/BACE2 or the word "amyloid," (http://journals.plos...al.pone.0147254) but:

 

I didn't know amylin (the pancreatic/diabetic version of alzheimers plaque) actually gets deposited in the brain.  Does anyone know if it's misfolded amylin like the plaques of alzheimers?

 

If so, which strategies can be used to clear or prevent its deposition in our pancreas?  Beta cells are about as good at entering S phase as brain cells.  Might be a good idea to keep them around.

 

See:

https://www.scienced...30627141812.htm

https://www.fightagi...imers-research/

http://journals.plos...al.pone.0147254

 

And evidence that T1D pancreas may be misfolding proteins on the way down: http://www.science20...echanism-143147 , though the premise of that being the whole story seems 'off.'

 

Others see the connection and propose immunotherapy.  Are any of the strategies for clearing the amyloid likely to be the same?  This is looking more and more like the same thing.  A bunch of ER stress depositing a bunch of garbage that needs to go away.  The ER stress needs to be relieved as well, but the first step is clearing the amyloid.


Edited by Logjam, 18 April 2016 - 11:11 PM.

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#2 LongLife

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Posted 06 May 2016 - 02:11 AM

LOGJAM;

Greetings. Beta is the name of a physical structure. Imagine the basic infrastructure of a metal frame building, a high-rise for instance. The frame network of some Amyloid protein takes on an "abnormal" structure; beta. Amyloid is found in every organ of the body; see videos on YouTube from the Mayo Clinic in MN. They do a nice job of explaining the subject matter. The Amyloid protein, produced in the bone marrow, is distributed via the blood and "accumulates"; is attracted to, and becomes a part of, muscles tissue. Muscle are similar in structure to cords. multiple strands of cords leave spaces between them. Amyloid is attracted to these spaces and fills the gap. Once filled, the gap increases in area as the beta (in this case beta-Amyloid) and the muscles are become swollen, larger, plus the beta-Amyloid is not plastic-pliable, it is ridged hard and difficult to move;fibrosis. The organs lose their plasticity, the organ walls become thick and difficult, the organ eventually fails to perform and a cascade effect takes place resulting in the organ dying. Simply put, no copyright :-) , a joke. 

 

Nilotinib (AMN107, trade name TASIGNA), currently / primarily used as a cancer medication is found to stop and dismantle the beta structure in Amyloid. Unfortunately it is not forever and must be cycled every so often. It has been found to work very well for Parkinson so far, as well as Amyloid in general. It has some nasty effects on those with current heart conditions. Nilotinib can alter the rhythm and cause problems with those that have a problematic heart. So under those conditions, the Nilotinib must be administered under supervision with other medication on hand to neutralize the effects and gain stability of the heart rhythm. See PubMed.

 

Nilotinib is an insurance drug meaning that only insurance companies can afford to pay for the treatment. Also extremely wealth individuals who desire to get rid of their beta-Amyloid plaque. A follow-up with Centrophenoxine (a/k/a/ Meclofenoxate / Lucidril) should keep the plaque at bay, which does not have to be administered every day as it has a long half life. Then some Nilotinib again and cycle. Depending on how much beta-Amyloid there is and where it is coming from; the cause. It is known to be formed in the marrow though, so why? I guess, science says it does not know yet. Tasigna/Nilotinib can be had for experimental use. Got a rat, maybe a cat?

 

YOUR QUESTION: If so, which strategies can be used to clear or prevent its deposition in our pancreas?

MY ANSWER: Vitamin D3, K2, with Omega3 (fish or fish oil) may prevent the formation of beta-Amyloid by "healing" the bone marrow cause. But these vitamins require some other substances to be efficient, such as zinc, lecithin, calcium and magnesium as well as selenium, B5, B6 and some exercise. So it is basically back to eating a good diet or supplementing, exercise and keeping active. 

 

The above formula most likely does not apply much since the S.A.D. diet is and has done its damage by age 20 in most all North Americans and Europeans. Stop all cooking oil intake. Clean the colon. Start a puritan diet of healthy oils and protein, loads of vegetables in variety, as well as supplementation, will "clear or prevent" the deposition of beta amyloid by stopping it from being produced, by carrying away what is formed already and by forming healthy proteins, collagen and cells. Exerciser is essential, no matter how little; it is like a "drug", a medicine, and science has now recognized it as so. We were never designed to be couch potatoes, correct?

 

 


Edited by LongLife, 06 May 2016 - 02:48 AM.


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