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Improve memory without causing depression?

memory depression acetylcholine dopamine

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#1 Axmann8

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Posted 21 April 2016 - 02:03 AM


I am looking for ways to improve memory that won't induce depression.

 

Whenever I take supplements such as huperzine A, alpha lipoic acid, or n-acetylcysteine, I seem to get in an extremely depressed mood.

 

Since acetylcholine and dopamine seem to have somewhat of an inverse relationship, I can only theorize that supplements increasing acetylcholine neurotransmission have the effect of temporarily lowering dopaminergic function. I could have this all wrong and it may be more of a cumulative thing than an acute effect, but acetylcholine-promoting supplements do seem to make me more depressed.

 

It seems that both my norepinephrine and serotonin levels are low, too. I'm currently taking Emsam (selegiline transdermal patch) at the 6 mg dose, so I'm not sure how this all factors in as well.

Any advice?



#2 iseethelight

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Posted 24 April 2016 - 02:19 PM

Acetylcholine in excess is anti-dopaminergic, and anti-serotonergic . That is the result of the depression. Increasing acetylcholine in excess will not make your memory better, it's the reverse in most cases. That is because of its inverse reaction on catecholamines. Dopamine and serotonin are required for memory formation and access as well.


Edited by iseethelight, 24 April 2016 - 02:20 PM.


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