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MTHRF-Mutation: Metafolin (Deplin etc.) vs. High folate food. ??!

metafolin 5-mthf 5-methyltetrahydrofolate psychosis mental health schizophrenia mthfr mutation mthfr mutation mthfr polymorphism

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#1 Omid

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Posted 25 April 2016 - 10:12 AM


Hello,

I have MTHFR-mutation. I don't know whether Homozygote or Heterozygote so I'll be tested for it in 1 month. My mother is Homozygote so I am at least Heterozygote or maybe homozygote if my father is at least heterozygote + bad luck.

 

I read a study which said people with schizophrenia with this mutation benefit from taking Metafolin. Particularly in the Negative symptom domain.

And exactly this is happening to me. I have some flavor of psychosis and I got myself Metafolin-like (glucosamine salt of (6S)-5-methyltetrahydrofolate) pills and I'm feeling my best since 12 years.

 

So my question is, is Folate from folate rich food already the activated form of Folate (5-methyltetrahydrofolate)? or is it a different form that needs the MTHFR to turn into 5-methyltetrahydrofolate?

I'd rather eat lots of folate rich food if it actually would work, but I have my doubts. My googling abilities failed completely on this one. So please help me out.

This question is very valid IMO because I believe taking a kind of folate that would not be converted to 5-methyltetrahydrofolate could actually be harmful because it would accumulate in the body without doing anything. And folic acid has been associated with risk of cancer and having lots of that accumulating.... I don't like the idea. So either there is 5-MTHF in the "food"or I'll go on taking my cheap 5-MTHF pills. btw, No Deplin in Germany AFAIK.

Cheerz

Omid

 

P.s: Is it possible that there are different kinds of folate in different food? I crave all kinds of liver like crazy although liver looks actually disgusting.



#2 pamojja

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Posted 25 April 2016 - 10:37 AM

Folic acid, the synthetic form, is a kind of monoglutamate . The folate from food is a mixture of mono- and polyglutamates. Monoglutamates are absorbed about >90%. Monoglutamates much less. Food having a mixture of these, it is generally assumed folates from foods are half absorbed then those from synthetic folic acid. Both have to be synthesized to 5-mthf in the body.
 

btw, No Deplin in Germany AFAIK.

 

high-potency-optimized-folate-l-methylfolate-5000-mcg-30-vegetarian-tablets is on sale at the moment. They ship from within the EU. Also have a 1 mg version.

 

 


Edited by pamojja, 25 April 2016 - 10:38 AM.


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#3 Omid

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Posted 25 April 2016 - 11:10 AM

Thank you for the information. I already have those from Life Extentions I had 1mg pills but ordered 5mg and it arrived just today. Thank god they supply from within EU. It's not possible to order supplements from US or any non EU country due to German law. Tried it once with glycine from US. Things got weird.







Also tagged with one or more of these keywords: metafolin, 5-mthf, 5-methyltetrahydrofolate, psychosis, mental health, schizophrenia, mthfr, mutation, mthfr mutation, mthfr polymorphism

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