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new study on alcohol use requires some explainations

serotonin gaba dhea alcohol ampa

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#1 normalizing

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Posted 30 April 2016 - 03:17 AM


this just recent article i have found; http://www.medicalne...ases/309734.php

 

it points to the well known fact it disturbs the serotonin transport system which is already well known but it surprised me with this "One of the changes shared by all alcoholics were increased levels of dehydroepiandrosterone in the brain. Dehydroepiandrosterone is a steroid hormone that affects the central nervous system. These increased levels can, for their part, explain alcohol tolerance, which develops as a result of long-term use and in which alcohol no longer causes a similar feeling of pleasure as before" and also "For instance, the brain samples of impulsive, type 2 alcoholics had increased levels of AMPA receptors in the anterior cingulate cortex. By modifying the function of synapses between neurons, AMPA receptors play a role in the learning and regulation of, e.g., behavioural models"

 

-so DHEA is naturally high in alcoholics, but DHEA is an antiaging neurosteroid, so is this actually a bad thing?

 

-does supplementing with DHEA after stopping alcohol use a good idea, meaning you want to keep the DHEA levels high or is it better to subside and not use DHEA because it contributes to tolerance and addiction? but also, sudden lowering of DHEA after alcohol use might also be related to depression!

 

-what about AMPA receptors and alcohol? does any substance that acts on AMPA receptors beneficial after alcohol cessation and which ones can those be?

 

-finally, clearly it screws with serotonin receptors, whats the best way to upregulate the serotonin transport system after alcohol use?
 



#2 OneScrewLoose

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Posted 30 April 2016 - 10:13 AM

Seems like a pretty lame study. First of all, they make no effort to discern whether these changes are a result of them being alcoholics (predisposed to alcoholism), or whether they are a result of alcohol intake.

 

i mean seriously, they site no amount of patients examined, in what manner though were examined, or whether this is a meta study. Worst of all, there are no sources. Since when does DHEA modulate alcohol tolerance? Well, we have no source to tell us. This couldn't even be called a study. This is a bunch of sentences on a paper.

 

Garbage.


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#3 normalizing

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Posted 30 April 2016 - 01:55 PM

Source: University of Eastern Finland

 

i really couldnt find the original paper of the study and thats the only source i can see. i do know medicalnewstoday always simplifies and summarizes a lot of interesting studies but i wish they do give a damn source url

 



#4 OneScrewLoose

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Posted 30 April 2016 - 09:17 PM

Well, I can't say your wrong. I just can't respond to a summary. I need a paper to dig into.



#5 APBT

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Posted 01 May 2016 - 02:30 PM

FULL TEXT:  http://epublications...2-61-2052-2.pdf



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#6 normalizing

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Posted 01 May 2016 - 10:58 PM

oh wow thank you APBT thats a lot of stuff to read through here not just that simple summary as in the article i posted :)






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