6 replies to this topic

[Reformed-Redan]

http://archpsyc.jama...ticleid=1686035

 

http://www.schizophr...ail.asp?id=1871

 

Thoughts? It seems too good to be true. 

 

Where can one obtain and how to administer safely sodium nitroprusside? 

[PeaceAndProsperity]

Very interesting but hopefully they are quick about larger trials.

If NO is all it's about, shouldn't l-arginine or the stronger metabolite, agmatine, work?

[Turnbuckle]

Niacin ought to be tried first as it is much safer.

[PeaceAndProsperity]

Niacin ought to be tried first as it is much safer.

Does niacin really work? Which version of it are you talking about? Dr. Abraham Hoffer said to take nicotinic acid slowly up to 10g a day. I tried that but it didn't seem to help my schizotypy

[Turnbuckle]

 

Niacin ought to be tried first as it is much safer.

Does niacin really work? Which version of it are you talking about? Dr. Abraham Hoffer said to take nicotinic acid slowly up to 10g a day. I tried that but it didn't seem to help my schizotypy

 

 

Niacin apparently works for some people but certainly not all, as schizophrenia doesn't have just one cause. I suggested niacin as an alternative to sodium nitroprusside as they seem to share some pharmacological characteristics, including for schizophrenia. Certainly niacin has many advantages as a therapy and is very easy to try informally.

 

Niacin-respondent subset of schizophrenia – a therapeutic review.

 

Abstract

It is well known that niacin deficiency manifests with several psychiatric manifestations. Also historically evidence has accumulated that niacin augmentation can be used for treatment of schizophrenia. However, the etiopathological associations between niacin deficiency and schizophrenia as well as the mechanism of action of niacin in its treatment. More importantly, the subgroups of schizophrenia which will respond to niacin augmentation has never been highlighted in the literature. In this article, we review three of the mechanisms in which niacin deficiency could lead to schizophrenic symptoms: (1) Niacin deficiency neurodegeneration (2) Membrane phospholipid deficiency hypothesis and (3) Adrenochrome hypothesis. We will further move towards the clinical as well as treatment related associations as reviewed from the literature. Here, we propose a model that a subset of schizophrenia can respond to niacin augmentation therapy better than other subsets because these patients have contributions in their psychotic manifestations from the neural degeneration resulting from niacin deficiency. We present a short description of our case report which showed rapid improvement in schizophrenic psychotic symptoms subsequent to administration of niacin as an augmentation therapy. We, thus, propose that niacin deficiency is a contributory factor in schizophrenia development in some patients and symptom alleviation in these patients will benefit from niacin augmentation, especially in some particular psychotic features.

 

http://www.europeanr...rg/article/8685

 

 

[PeaceAndProsperity]

 

 

Niacin ought to be tried first as it is much safer.

Does niacin really work? Which version of it are you talking about? Dr. Abraham Hoffer said to take nicotinic acid slowly up to 10g a day. I tried that but it didn't seem to help my schizotypy

 

 

Niacin apparently works for some people but certainly not all, as schizophrenia doesn't have just one cause. I suggested niacin as an alternative to sodium nitroprusside as they seem to share some pharmacological characteristics, including for schizophrenia. Certainly niacin has many advantages as a therapy and is very easy to try informally.

 

Niacin-respondent subset of schizophrenia – a therapeutic review.

 

Abstract

It is well known that niacin deficiency manifests with several psychiatric manifestations. Also historically evidence has accumulated that niacin augmentation can be used for treatment of schizophrenia. However, the etiopathological associations between niacin deficiency and schizophrenia as well as the mechanism of action of niacin in its treatment. More importantly, the subgroups of schizophrenia which will respond to niacin augmentation has never been highlighted in the literature. In this article, we review three of the mechanisms in which niacin deficiency could lead to schizophrenic symptoms: (1) Niacin deficiency neurodegeneration (2) Membrane phospholipid deficiency hypothesis and (3) Adrenochrome hypothesis. We will further move towards the clinical as well as treatment related associations as reviewed from the literature. Here, we propose a model that a subset of schizophrenia can respond to niacin augmentation therapy better than other subsets because these patients have contributions in their psychotic manifestations from the neural degeneration resulting from niacin deficiency. We present a short description of our case report which showed rapid improvement in schizophrenic psychotic symptoms subsequent to administration of niacin as an augmentation therapy. We, thus, propose that niacin deficiency is a contributory factor in schizophrenia development in some patients and symptom alleviation in these patients will benefit from niacin augmentation, especially in some particular psychotic features.

 

http://www.europeanr...rg/article/8685

 

 

 

Interesting. Wasn't there something with brain inflammation or systematic inflammation and schizophrenia, and niacin is anti-inflammatory?

[Reformed-Redan]

 

 

Niacin ought to be tried first as it is much safer.

Does niacin really work? Which version of it are you talking about? Dr. Abraham Hoffer said to take nicotinic acid slowly up to 10g a day. I tried that but it didn't seem to help my schizotypy

 

 

Niacin apparently works for some people but certainly not all, as schizophrenia doesn't have just one cause. I suggested niacin as an alternative to sodium nitroprusside as they seem to share some pharmacological characteristics, including for schizophrenia. Certainly niacin has many advantages as a therapy and is very easy to try informally.

 

Niacin-respondent subset of schizophrenia – a therapeutic review.

 

Abstract

It is well known that niacin deficiency manifests with several psychiatric manifestations. Also historically evidence has accumulated that niacin augmentation can be used for treatment of schizophrenia. However, the etiopathological associations between niacin deficiency and schizophrenia as well as the mechanism of action of niacin in its treatment. More importantly, the subgroups of schizophrenia which will respond to niacin augmentation has never been highlighted in the literature. In this article, we review three of the mechanisms in which niacin deficiency could lead to schizophrenic symptoms: (1) Niacin deficiency neurodegeneration (2) Membrane phospholipid deficiency hypothesis and (3) Adrenochrome hypothesis. We will further move towards the clinical as well as treatment related associations as reviewed from the literature. Here, we propose a model that a subset of schizophrenia can respond to niacin augmentation therapy better than other subsets because these patients have contributions in their psychotic manifestations from the neural degeneration resulting from niacin deficiency. We present a short description of our case report which showed rapid improvement in schizophrenic psychotic symptoms subsequent to administration of niacin as an augmentation therapy. We, thus, propose that niacin deficiency is a contributory factor in schizophrenia development in some patients and symptom alleviation in these patients will benefit from niacin augmentation, especially in some particular psychotic features.

 

http://www.europeanr...rg/article/8685

 

 

 

I think the effects of SNP are through epigentic mechanism on the CBS synthesis of H2S. I mean, the effects persist for 4 weeks, long after the initial effects of SNP on NO levels are gone. H2S deserves more attention for the matter.