106 replies to this topic

[jackinbox]

I began to use Deprenyl (Selepryl brand) this morning. I used two drops in the morning and two drops in the afternoon. I'm a bit nervous with this product. How should I process to know if it work? Which dosage? Which of this stuff should I avoid to take while on deprenyl:
Aniracetam
Piracetam
Choline Bitrate
Pyritinol
DMAE
Vinpocetine
Pyritinol
Picamilon
Ginkgo biloba
Rhodial rosea
Huperzine A
Oxiracetam
Melatonine
5-HTP
Valerian
Deprenyl
Desmopressin
Alpa-GPC
Bacopa
Theamine

[gcurrie]

Each drop = 1 mg (approx). So you are taking 4 mg a day.

Unless you are 45-50, that is probably a little much. What is your age?

I take everything on your list with deprenyl except:
Choline bitartrate (I take alpha GPC for my nootropic choline)
DMAE
Gingko
5-htp
Valerian
Desmopressin

Why are you taking deprenyl? Life extension or nootropic reason (or both)?

[jackinbox]

I'm 27 year old. I'm taking deprenyl for motivation and counter my ADD. So, it's the nootropic effect that interest me.

[Karomesis]

some advice jackinbox; watch your response to stressors carefully, I have recently had the unfortunate occurence of extreme road rage that I partially attribute to 4mg deprenyl a week. The studies suggest that mounting frequency in rats and humans increases and dopamine release is stronger, I can personally vouch for both phenomenon, as can my not so fortunate wife [lol] let's just say my eyes roll back in my head and expletives herald my delerium. [:o] [:o]

[eternaltraveler]

I took a small amount of deprenyl (~5 mg/week) for a little while but was noticing symptoms of too much dopamine so I stopped. In my case I don't think I will take it again for ten years or so. I'm also 27.

[jackinbox]

What's are the first signs of dopamine overload?

[wannafulfill]

it's not the first sign, but a sure one is experiencing mania

[liorrh]

I am taking 5mg a day and don't feel adverse effects... I am 30. when coupled with other stims though, you sure can get burned much quicker.

[jackinbox]

How long should it take before I get results?

[Karomesis]

I got results similar to justins in about 2 weeks, I have since stopped taking it for the aforementioned reason. [mellow] For me at least, it's just too dangerous to continue and potentially jeapordize my current lifestyle.

[jackinbox]

I took 4 mg the last two days and 5 mg today sublingualy. My heartbeat went up to 110. I have similar problems with stimulants (ritalin, dexedrine). I don't know if it's because one of the metabolites of deprenyl is methampetamine. It took about 5 hours to my heart to quiet down.

[deekz]

With tablets you get results in a day or two at doses of 5mg or more. If using 5mg or more you need to lower amounts of your nootropics and caffine. I tried taking 10mg a day along with my nootropics but i was way overstimulated. I quit all nootropics but deprenyl about 2 months ago and been using 5mg since then, and uped to 10 mg last 15 days. I feel great with no anxiety or overstimulation.

at 10mg.. are you by any chance watching what you eat? I've always wanted to experiment with such a high dose but extremely worried about inhibiting MAOI-A. I'm doing fantastic at 5mg/day but sometimes even consider that a high dose.

[hiredavidrnow]

My Dad has had quite the life... He is 58, and had an accident where he fell 10 feet and cracked his pelvis in 6 places as well as fracturing his right hip. He fell because he was electricuted and also has had more then 50% nerve damage in his dominant right arm.
At my suggestion, he just ordered and recieved his first shipment of deprenyl.
He has been having problems with his memory, and with overall motivation. He is motivated to work, however his body is not complying.

Does anyone have any suggestions?

Thanks!

[jerebaldo1]

I know that Deprenyl is irreversible towards Mao-B, but what about when it crosstalks with Mao-A? I bet he's had pizza since he did the 10mg. Either 10mg still isn't enough to inhibit Mao-A in his system or else it is a reversible Mao-A inhibitor in which case it doesn't cause the cheese sickness. Hmm, pubmed time.

Hiredavidrnow: Sorry about that dude that fucking sucks! So he's got nerve damage and bone damage. Dad should be taking Sam-e, no question. He needs something that's pro-joint and pro-active. That, magnesium, calcium, Centrum Silver multivitamins, alpha-lipoic acid, and Acetyl-Carnitine. Such a stack isn't as expensive as most while at the same time covering many of the beleaguered bases that comes with injury and age [thumb].

[jegrx]

Jerebaldo - I think the dose for MAO-A inhibition is 20mg/daily...


Aside from current discussion...Does anyone know if there would be any detriment/benefit to using deprenyl just once or twice a week, say 5mg a dose? The meth and amphetamine metabolites are only detectable in a drug test for 24-48 hours, so, this dosing scheme would work around that. Thanks.

[jegrx]

Does anyone know if there would be any detriment/benefit to using deprenyl just once or twice a week, say 5mg a dose? The methamphetamine and amphetamine metabolites are only detectable in a drug test for up to 24 hours, correct?  Thanks.

Anyone?

[jackinbox]

Why don't you use a small dose of liquid deprenyl (2-3 drops) everydays?

[jegrx]

JackinBox - Taking it once a week would be to avoid failing a drug test, since (from what I've read), the amphetamine/methamphetamine metabolites are only detectable for up to 24 hours or so.

Da sense - Good to know there will be some benefit to once a week, but, notso good that I'll need 5mg daily for the mood benefits.

[mitkat]

JackinBox - Taking it once a week would be to avoid failing a drug test, since (from what I've read), the amphetamine/methamphetamine metabolites are only detectable for up to 24 hours or so.

Da sense - Good to know there will be some benefit to once a week, but, notso good that I'll need 5mg daily for the mood benefits.

My brother is interested in taking deprenyl, he's 28 (I feel a bit too young for it still - 24) and he's getting tablets. Would the benefit of taking 5mg or so a week be worth it at all, from a mood enhancing point of view? I've looked for such studies, but "mood" isn't the most objective term, so I'm interested in what anyone has to say about, let's say between 5-15mg a week?

[jegrx]

JackinBox - Taking it once a week would be to avoid failing a drug test, since (from what I've read), the amphetamine/methamphetamine metabolites are only detectable for up to 24 hours or so.

Da sense - Good to know there will be some benefit to once a week, but, notso good that I'll need 5mg daily for the mood benefits.

My brother is interested in taking deprenyl, he's 28 (I feel a bit too young for it still - 24) and he's getting tablets. Would the benefit of taking 5mg or so a week be worth it at all, from a mood enhancing point of view? I've looked for such studies, but "mood" isn't the most objective term, so I'm interested in what anyone has to say about, let's say between 5-15mg a week?

I'm not sure, but, I'll be starting tomorrow. I'll let you know.

[power.bulls.x]

i am 22 years old. i was used to take 1mg-2.5mg tablet/day and fell a gentle increase in heart speed (could be the amphetamine) but no more such a side effect.

Just wondering if tolerance can build up over time be cause now i feel my self i need more to fell the same (After 3month discontinuation of use for sports drug test & competition). Or i just messed up withe my dopamine system. Or it is a side of my recent acutane usage (1 month@20mg/day)

glad to hear it from you. i was a bit woried

Edited by power.bulls.x, 15 February 2007 - 07:02 PM.

[jegrx]

I'm trying to figure this whole drug test thing, and selegiline. Am I correct in seeing that only .2-20ng/mL was detected for methamphetamine and amphetamine?

Published: Journal of Analytical Toxicology, ISSN 0146-4760, Volume 26, Number 7, October 2002, pp. 430-437

Quantitative Analysis of Selegiline and Three Metabolites (N-Desmethylselegiline, Methamphetamine, and Amphetamine) in Human Plasma by High-Performance Liquid Chromatography–Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry
Matthew H. Slawson, James L. Taccogno, Rodger L. Foltz, and David E. Moody
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112

This report describes a sensitive and specific high-performance liquid chromatography-atmospheric pressure chemical ionization–tandem mass spectrometry method for the detection of subnanogram concentrations of selegiline and its three principle metabolites, N-desmethylselegiline, methamphetamine, and amphetamine, in human plasma. The assay has a dynamic range of 0.1–20 ng/mL for selegiline and N-desmethylselegiline (norselegiline) and 0.2–20 ng/mL for methamphetamine and amphetamine. The inter- and intra-assay precision and accuracy varied by less than 11% for all analytes at 0.3, 2.5, and 15 ng/mL and less than 16% at the lower limit of quantitation (0.1 ng/mL for selegiline and norselegiline; and 0.2 ng/mL for methamphetamine and amphetamine). Selegiline and its metabolites showed no significant loss in quantitative accuracy after three freeze/thaw cycles or after up to 6 h at room temperature prior to extraction. Extracted plasma samples retained quantitative accuracy after storage for at least 7 days at –20°C or up to 70 h at room temperature. Methanolic stock solutions were stable for at least 6 h when kept at room temperature or at least 90 days when kept at –20°C.

This one says amphetamine metabolites were detected at 3.5 ng/mL and methamphetamine was detected at 8 ng/mL.

Pharmacokinetic Information (Absorption, Distribution, Metabolism and Elimination--ADME): Only preliminary information about the details of the pharmacokinetics of selegiline and its metabolites is available.

Data obtained in a study of 12 healthy subjects that was intended to examine the effects of selegiline on the ADME of an oral hypoglycemic agent, however, provides some information. Following the oral administration of a single dose of 10 mg of selegiline hydrochloride to these subjects, serum levels of intact selegiline were below the limit of detection (less than 10 ng/ml). Three metabolites, N-desmethyldeprenyl, the major metabolite (mean half-life 2.0 hours), amphetamine (mean half- life 17.7 hours), and methamphetamine (mean half-life 20.5 hours), were found in serum and urine. Over a period of 48 hours, 45% of the dose administered appeared in the urine as these 3 metabolites.

In an extension of this study intended to examine the effects of steady state conditions, the same subjects were given a 10 mg dose of selegiline hydrochloride for seven consecutive days. Under these conditions, the mean trough serum levels for amphetamine were 3.5 ng/ml and 8.0 ng/ml for methamphetamine; trough levels of N-desmethyldeprenyl were below the levels of detection.
http://www.best-meds...yl_clinical.htm

This one says that amphetamine needs 500 ng/mL to test positive, and 200 ng/mL from methamphetamine. I have also seen these elsewhere...

DRUG                        SCREENING CUTOFF                    GC/MS CUTOFF

Amphetamines Class            500                                      500
  Amphetamine                        500
  Methamphetamine              200
Barbituates                              200                                      100
Cocaine                                        150                                        150
Marijuana                                    50                                          15
Opiates                                      300
  Codeine                                                                          300
  Morphine                                                                      300
Phenyclidine                                25                                          25

All cutoff levels are in nanograms/mL
http://www.erowid.or...sting_faq.shtml

So, according to all this, selegiline shouldn't cause a positive result on a UA, correct? I'm still getting used to reading studies and whatnot (somewhat overwhelming...). Thanks.

[power.bulls.x]

good to know that selegiline isnt likely to triger ...

do this mean i can take it witout the fear of getting banned for like 2 years .

EDIT: i ve been tested many times without any problems.
[thumb]

Edited by power.bulls.x, 20 January 2007 - 10:10 AM.

[jegrx]

pbx06
amphetamines that are metabolised from selegiline are l-amphetamines - legal ones, street drugs contain d-amphetamines - illegal

some test check for d- only, while some tests check for any kind of amphetamines. if your test ever shows positive due to selegiline you can always ask for better test for d-amphetamines only

Would the military go for that though? They have that "We're not happy till your not happy!" Their drug tests might even only test for the d isomers. I don't know.