8 replies to this topic

[thedevinroy]

Wondering what anybody's experience is with the AC-11 extract from Cat's Claw. Specifically, I'm wondering it's most noticeable psychological and physiological effects, especially in comparison to other Cat's Claw extracts. My guess is that it is more of an immune booster, less of an NMDA antagonist. Haven't looked too deep yet, so let me know if it is also something you're interested in delving into.

[Logic]

GoogleSiteSearch:

https://cse.google.c...Claw&gsc.page=1

 

I like the DNA repair.

[thedevinroy]

Theoretically it sounds pretty awesome for age reversal, but I also need a more potent NMDA antagonist to my regime. I figure it looked interesting enough, and it's part of the nootropic herbal formula, Alpha Brain, which has quite a few solid reviews.

Edited by devinthayer, 23 May 2016 - 09:36 PM.

[thedevinroy]

I went to the Vitamin store and picked up some Cat's Claw. Didn't say it was an extract, so it probably isn't one. I took two 500mg pills the other night.

Within 15 minutes, I felt the effects, a non-euphoric sedation. Pretty strong, too. The kind that makes you want to sit there and veg out. Within 30 minutes, I had a migraine and dizziness. I woke up with allergies the next morning like none other. Seems the psychoactive, cardiovascular, and immune boosting effects are a bit too strong for me at 1000mg first use.

Last night, I only took one 500mg pill. Felt calm, but no sedation, no headaches, and very little dizziness. No allergies in the morning either.

Based on this, I'm willing to give this AC-11 a shot. It seems I don't need an extract to get the NMDA antagonistic effects, and the side effects are very dose dependent and/or lessen with use.

Edited by devinthayer, 25 May 2016 - 11:08 AM.

[normalizing]

so just plain basic extract with no standardization of any actives is just as noticeable? interesting. do you think the sedation is more like dissociation and is related to its NMDA effect or its something else?

Edited by normalizing, 25 May 2016 - 01:16 PM.

[thedevinroy]

Rhinchophyline or something? Probably... I mean, it was pronounced like maybe there was a direct effect on adrenaline


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[sativa]

Cats claw apparently has MAOBi as well as NMDA antagonsism. It also interacts with the 5-HT2A receptor. This is due to Rhinchophyline I think, which contains a slightly modified DMT molecule within its structure.

[Logic]

Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity.

http://www.ncbi.nlm....pubmed/20736055

 

Pharmacological  actions of Uncaria alkaloids,rhynchophylline and isorhynchophylline

http://www.chinaphar...-4083/24/97.pdf

 

 

[thedevinroy]

Very interesting articles there. It increases 5-HT and decreases DA. Makes sense given my experience. I suppose if you're trying to come down from caffeine or some other stimulant, that might make sense... Also good for GAD and BPD.

The affect on Potassium channels was interesting. I wonder if that's what actually delivers the migraines.


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