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Effects of resveratrol and exercise in middle-aged mice

resveratrol in vivo

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#1 malbecman

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Posted 31 May 2016 - 03:44 PM


Still looks to be something going on there......

 

 

Molecules. 2016 May 18;21(5). pii: E661. doi: 10.3390/molecules21050661.

Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice.
Abstract

Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise performance of aged mice. C57BL/6J mice (16 months old) were randomly divided into four groups: an older control group (OC group), supplementation with RES group (RES group), ET group (ET group), and a combination of ET and RES supplementation group (ET+RES group). Other 10-week-old mice were used as a young control group (Y-Ctrl group). In this study, exercise performance was evaluated using forelimb grip strength and exhaustive swimming time, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. Our results showed that the forelimb grip strength of mice in the ET+RES group was significantly higher than those in the OC, RES, and ET groups (by 1.3-, 1.2-, and 1.1-fold, respectively, p < 0.05), and exhibited no difference with the Y-Ctrl group. The endurance swimming test showed that swimming times of the ET and ET+RES groups were significantly longer than those of the OC and RES groups. Moreover, plasma lactate and ammonia levels of the ET + RES group after acute swimming exercise were significantly lower compared to the OC group (p < 0.05). Thus, it was suggested that by combining RES supplementation with ET for 4 weeks, the muscle strength and endurance performance of aged mice were significantly improved compared to the single intervention with either RES or ET alone. This combination might help shorten the extent of deterioration accompanying the aging process. 

KEYWORDS: 

anti-fatigue; exercise performance; resveratrol

PMID:   27213310

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#2 normalizing

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Posted 06 June 2016 - 03:42 AM

so is resveratrol good or bad with exercise? im still confused as i read quite the opposite few times now. HELP! someone please check the sponsor of this study!!!



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#3 maxwatt

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Posted 06 June 2016 - 03:50 AM

Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice.

Author information
  • 1Center for Liberal Arts, Taipei Medical University, Taipei 11031, Taiwan. kevinkan@tmu.edu.tw.
  • 2Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. kilmur23@ntsu.edu.tw.
  • 3Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. 1021301@ntsu.edu.tw.
  • 4Department of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan. 1021301@ntsu.edu.tw.
  • 5School of Nutrition and Health Sciences, Taipei Medical University, Taipei City 11031, Taiwan. 1021301@ntsu.edu.tw.
  • 6Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. magicpica521@gmail.com.
  • 7Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. 1010206@ntsu.edu.tw.
  • 8Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. peggytung@ntsu.edu.tw.
  • 9Graduate Institute of Sports Science, National Taiwan Sport University, 250 Wenhua 1st Rd., Guishan Township, Taoyuan County 33301, Taiwan. john5523@ntsu.edu.tw.

 

Acknowledgments
This research was supported by the Ministry of Science and Technology of Taiwan, the successor to the National Science Council (grant no. NSC102-2628-H179-001-MY2 to Chi-Chang Huang). The authors are grateful to Chien-Chao Chiu and Hsiao-Li Chuang for their technical assistance in animal experiments.
Author Contributions
Nai-Wen Kan, Yu-Tang Tung, and Chi-Chang Huang designed the experiments. Chin-Shan Ho, Yen-Shuo Chiu, Wen-Ching Huang, and Pei-Yu Chen carried out the laboratory experiments. Nai-Wen Kan, Chin-Shan Ho, and Chi-Chang Huang contributed reagents, materials, and analysis platforms. Nai-Wen Kan, Chin-Shan Ho, Yu-Tang Tung, and Chi-Chang Huang analyzed the data, interpreted the results, prepared figures, and wrote the manuscript. Nai-Wen Kan, Yu-Tang Tung, and Chi-Chang Huang revised the manuscript.
Conflicts of Interest
The authors declare no conflict of interest.

 


Edited by maxwatt, 06 June 2016 - 03:53 AM.

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#4 normalizing

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Posted 06 June 2016 - 09:10 AM

with such names as chang cheng ping pong etc. it was hard for me to google and find what each one of those people gets out of this study, so ill say i guess they dont work for any resveratrol producing company? we shall see in later studies.


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#5 Vlad Bondarenko

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Posted 08 July 2016 - 03:02 PM

so is resveratrol good or bad with exercise? im still confused as i read quite the opposite few times now. HELP! someone please check the sponsor of this study!!!

From what I understand, Resveratrol combined with exercise increased the muscle endurance and strength of the mice. This increased endurance and strength seems to lessen the "side-effects" of aging. 

 

OP: The links are broken.

 

I somewhat cannot agree with this (as much as I want to), because exercise in general will increase performance and endurance of muscles, so reservatrol might only increase help this further.


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#6 normalizing

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Posted 10 July 2016 - 03:20 AM

what about resveratrol and fasting?



#7 QQQ

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Posted 17 July 2016 - 07:00 PM

with such names as chang cheng ping pong etc. it was hard for me to google and find what each one of those people gets out of this study, so ill say i guess they dont work for any resveratrol producing company? we shall see in later studies.

 

That's a shame because you seem really intelligent


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#8 Daniscience

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Posted 29 July 2016 - 05:06 PM

what about resveratrol and fasting?

 

Yeah I am interested on this, I usually fast following a 20/4 protocol and I lift weights and a bit of cardio on the latest hours of my fasting.







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