Nicotine has a powerful and documented nootropic effect through its nicotinic acetylcholine receptor agonism. Both nicotine and muscarine are highly toxic at high doses. Acetylcholine itself is highly nootropic. Could muscarine be equally powerful but work through the other subtype of acetylcholine receptors? I see a complete lack of commercial availability or interest in the mAchR system but an abundance in the nAchR system. perhaps this is misplaced?
Muscarinergic Acetylcholine receptor agonists have nootropic properties:
https://en.wikipedia...wiki/Xanomeline
https://en.wikipedia.org/wiki/CI-1017
https://en.wikipedia...wiki/Tazomeline
…As do positive allosteric modulators of these receptors:
https://en.wikipedia...wiki/77-LH-28-1
Also, some analgesic properties:
https://en.wikipedia...iki/Vedaclidine
Partial Agonists seem to lack significant nootropic effects:
https://en.wikipedia...ki/Talsaclidine
https://en.wikipedia...iki/Sabcomeline
https://en.wikipedia...wiki/Milameline
So, wouldnt muscarine be expected to posses all the benefits of other muscarinic acetylcholine receptor agonists?