11 replies to this topic

[mikeinnaples]

I have a 13 y/o Parson Russel Terrier (17lbs) that was diagnosed last week with cancer in her sinus cavity. She has a significant sized tumor that has taken over her right sinus cavity. Given her age and the size of the tumor, surgery and classic cancer treatment is not recommended. She was also given less than three months as her symptoms and health are expected to go rapidly down hill. Part of being a responsible and good parent to a pet is knowing when her suffering is not tolerable. She is not there yet, not even close and I will be prepared to do what has to be done when the time comes. With that said, as someone who sincerely loves my furry child, I want to do what I can for her. I realize 'curing' my pup isn't likely to happen, but as it stands she had 0 chance of living out the rest of her life.... so anything I can do within reason is better than no chance at all.

 

Here is what I am doing, and any advice or insight would be helpful:

 

1. Ketogenic Diet - we are making her food now and ensuring proper micros as well. 70% Fat (healthy sources), 24% Protein, 6% carbs is her macro breakdown.

 

2. Mebendazole - 10mg BID and will scale up to 50mg BID if tolerable to her.

 

3. Apigenin - 50mg BID

 

4. Resveratrol (98% micronized) - 150mg BID

 

5. ECGC - 25mg BID

 

6. Quercetin - 200mg BID (w/ 42.5mg Bromelain)

 

 

In addition, we will probably be adding this receptor tyrosine kinase inhibitor:

 

7. Toceranib - 25mg every other day

 

 

 

Edited by mikeinnaples, 07 July 2016 - 04:10 PM.

[aconita]

I would definitely try kerosene.

 

http://www.health-sc...it.com/kero.htm

 

Squirt it down her troat with a syringe (no needle, of course).

 

Nothing to loose at this stage and if it works you'll get a very interesting confirmation I hope you'll share here too.

 

Give her just the food she likes best, at worst you are going to make her happy those last days.

 

 

[mikeinnaples]

Her being on keto now has some pretty good study based evidence going for it when it comes to glycolysis and cancer. Fortunately she also loves taste of the home made food.

 

 

As far as kerosene goes, I am not giving that to my dog. That seems to be pure quackery unless you are suggesting I use it to put her down with.

[aconita]

I do understand your disappointment for not having a double blind clinically proven effective cure suggested for terminal cancer...

 

kerosene must be quackery since all the money Shell oil is going to make selling it to cancer patients...not like resveratrol  which cost an arm and a leg, no efficacy whatsoever in vivo for any health benefit, bioavailability close to zero in a complex digestive system like the human one...leave alone a much simpler and faster like the dog....

 

Just wondering what were you feeding your dog if now you decided to go keto...by the way it sounds like a really good idea to feed carnivorous with no carbs but I am afraid not a very revolutionary one.

 

 

 

 

[mikeinnaples]

The only thing I am doing for her that doesn't have canine specific studies backing it is resveratrol. My choice for including that is due to other animal studies and feedback from other dog owners that have given it to theirs with cancer.

 

Really not sure why you are bothering to post when you are just being sarcastic. Get a kick out of it?

 

 

Edited by mikeinnaples, 08 July 2016 - 03:33 PM.

[aconita]

That's right, you don't deserve my attention.

 

Good luck and thanks for your friendly kindness.

[zorba990]

Sodium butyrate synergizes with resverstrol
e.g. http://m.jn.nutritio...132/7/2082.full

Maybe after some self experimentation you woukd consider saline or coconut oil with res and quercetin via direct aplicatin to the area.

Ultrasound synergizes with quercetin
http://www.ncbi.nlm....les/PMC2362095/
but 20khz is hard to find. 1mhz is easily found but may be less efficacious
https://www.amazon.c...r/dp/B01FXNB0D4

[Psilociraptor1]

I recall reading a lot of people giving their dogs artemisinin that were pretty happy. I believe this is the study http://www.ncbi.nlm....les/PMC4004853/ Haven't read it as i was using it for other purposes, but hopefully it helps. Abstract seems promising

[zorba990]

I would definitely try kerosene.

http://www.health-sc...it.com/kero.htm

Squirt it down her troat with a syringe (no needle, of course).

Nothing to loose at this stage and if it works you'll get a very interesting confirmation I hope you'll share here too.

Give her just the food she likes best, at worst you are going to make her happy those last days.

Researching Kerosene is proving to be suprisingly interesting

e.g. http://www.sciencedi...214750014001528

Effects of crude kerosene on testosterone levels, aggression and toxicity in rat
Rachel W. NjorogeBenson N. MachariaDinah J. SaweGeoffrey K. Maiyoh
Show more
Highlights
•
Kerosene supplementation increases serum testosterone levels in rat.
•
Increased testosterone levels were associated with increased aggression.
•
Kerosene supplementation had varied effects on blood parameters, notably, increased WBC counts.
•
Supplementation resulted in active/chronic gastritis in the stomach of our rat model.

But seems no liver or kidney toxicity which is suprising. Gastritis could probably be prevented with co administration of phoschol .

[Psilociraptor1]

Being that i already recommended an antimalarial it got me thinking about this... cryptolepis seems to be a potentially promising anticancer herb that intercalates DNA and prevents synthesis among other things. This also makes it a potent antibacterial (which i really think also plays a role in cancer). Anyways, no clue if it will work or not, the science is very early on http://www.ncbi.nlm....les/PMC3875281/ But what I do know from first hand experience is that it is very systemic and a VERY potent antibacterial. I mean forget olive leaf and all that, 1 tsp of this over 24 hours put me on my ass from all the herx. So, if those same principles are at play it might be worth a shot with your pooches tumor. But definitely give that artemesia a look as I've heard a lot more about people using it on their pets with good results. And know that you should be pulsing it as it becomes less effective after a week or two.

[mikeinnaples]

2 Week Update - Small decrease in the size of the tumor.

 

 

I did put her on Toceranib as well, but at 15mg 2x/day  on a M-W-F dosing schedule. Her appetite comes and goes but she has not lost any weight. She is having some stomach cramping issue after taking the Toceranib and some lower GI bleeding as evidenced by her stool (just started 3 days ago). Her nose bleeds are still present but have overall decreased slightly. Probably going to adjust her food some and supplement intake until the lower GI issue resolves.  A little less of the oils in her food and stopping everything but the Toceranib and Mebendazole for a couple of days and the reintroduce the sups one at a time.

 

Edited by mikeinnaples, 21 July 2016 - 03:30 PM.

[zorba990]

Consider phoschol for the gi issues
http://www.phoschol....ch/gastric2.php

Sounds like you are doing well, so don't rush it, it takes time to remove the dead cells.
Consider getting / learning lymph drainage massage.
http://www.cancerdef...r-Recovery.html