autumn knight, antipsychotics are very very bad idea for people like us to take them. thats why this guy recommending haloperidol is just uneducated about DRD2 problems. you definitely do not take antipsychotics! forskolin doesnt work either i took it for a month or so and gamesguru's suggestions are always a huge fail as those have been used for many years with mostly negative long term effect.
If you read the article i posted, you'll notice that the dosage used was about 1/50 of the lowest therapeuthic dose, (2mg), at this levels the antipsychotic won't block any dopamine receptors, but will rather sensitize then, by an unknown mechanism. the study was conducted on parkinson's patients. as you might imagine, blocking their dopamine receptors would be disastrous, so i'm sure that you'll be okay if try this.
"A possible method of enhancing the action of dopaminergic therapy is to increase the sensitivity of dopamine D2 receptors that are the main targets for dopamine agonists [2]. For example, very low doses of dopamine antagonists can increase the number of D2 receptors that are in the high-affinity state for dopamine, known as D2High receptors [3]. Such an increase in brain striatal D2High receptors is consistently associated with increased motor activity in animals [4, 5], indicating increased behavioural sensitivity.
For example, Alttoa et al. [4] found that spontaneous exploratory behavior was related to the proportion of D2 receptors in the high-affinity state in laboratory animals. On the basis of their initial spontaneous exploratory behavior, one-month postnatal rats were divided into high- and low-curiosity groups. The low-curiosity group showed a level of high-affinity D2 receptors that averaged 22.5% of the total D2 population of receptors, while the high-curiosity animals revealed a D2High receptor level of 43.8%. These results suggest a relationship between the D2High state and the increased motor and exploratory behavior in rats.
In another study [5], rats were administered haloperidol i.p. at a dose equivalent to 0.4% of the human dose for its approved indications (psychosis). After several successive days, the high-affinity D2 receptors increased by more than 50%, resulting in a level approximately twice that of untreated animals. The animals exhibited heightened locomotion, active exploration, and increased grooming behavior. These results were still demonstrable for several days after dosing was stopped."
Edited by Guinga, 16 August 2016 - 02:54 PM.